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Science Forum Index » Life Extension Forum » Human ApoD, an apolipoprotein up-regulated in...
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 Posted: Fri May 09, 2008 1:50 pm |
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Proc Natl Acad Sci U S A. 2008 May 5 [Epub ahead of print] Links
Human ApoD, an apolipoprotein up-regulated in neurodegenerative
diseases, extends lifespan and increases stress resistance in
Drosophila.Muffat J, Walker DW, Benzer S.
Division of Biology, California Institute of Technology, Pasadena, CA
91125.
Apolipoprotein D (ApoD) expression increases in several neurological
disorders and in spinal cord injury. We provide a report of a
physiological role for human ApoD (hApoD): Flies overexpressing hApoD
are long-lived and protected against stress conditions associated with
aging and neurodegeneration, including hyperoxia, dietary paraquat,
and heat stress. We show that the fly ortholog, Glial Lazarillo, is
strongly up-regulated in response to these extrinsic stresses and also
can protect in vitro-cultured cells in situations modeling Alzheimer's
disease (AD) and Parkinson's disease (PD). In adult flies, hApoD
overexpression reduces age-associated lipid peroxide accumulation,
suggesting a proximal mechanism of action. Similar data obtained in
the mouse [Ganfornina, M.D., et al., (2008) Apolipoprotein D is
involved in the mechanisms regulating protection from oxidative
stress. Aging Cell 10.1111/j.1474-9726.2008.00395.] as well as in
plants (Charron et al., personal communication) suggest that ApoD and
its orthologs play an evolutionarily conserved role in response to
stress, possibly managing or preventing lipid peroxidation.
PMID: 18458334 [PubMed - as supplied by publisher] |
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