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Science Forum Index » Life Extension Forum » EGCG reduces beta-amyloid mediated cognitive...
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| RArmant... |
 Posted: Thu May 08, 2008 10:11 pm |
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Brain Res. 2008 Apr 7 [Epub ahead of print]
Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid
mediated cognitive impairment and modulates tau pathology in Alzheimer
transgenic mice.
Rezai-Zadeh K, Arendash GW, Hou H, Fernandez F, Jensen M, Runfeldt M,
Shytle RD, Tan J.
Rashid Laboratory for Developmental Neurobiology, Silver Child
Development Center, Department of Psychiatry and Behavioral Medicine,
USA.
We previously reported that intraperitoneal (i.p.) injection (20
mg/kg) of (-)-epigallocatechin-3-gallate (EGCG), the main polyphenolic
constituent of green tea, decreased beta-amyloid (Abeta) levels and
plaques via promotion of the non-amyloidogenic alpha-secretase
proteolytic pathway in "Swedish" mutant amyloid precursor protein
overexpressing (APPsw, Tg) mice. Here, we find that EGCG administered
orally in drinking water (50 mg/kg) similarly reduces Abeta deposition
in these mice. Following a six month treatment of an 8 month old cohort,
immunohistochemical analysis of coronal sections reveals that plaque
burdens were reduced in the cingulate cortex, hippocampus, and
entorhinal cortex by 54%, 43%, and 51%, respectively. Congo red plaque
burdens were decreased in the cingulate cortex, hippocampus, and
entorhinal cortex by 53%, 53%, and 58%, respectively as well. ELISA of
brain homogenates of the treatment Tg mice revealed consistent
reductions in both Abeta(1-40) and (1-42) soluble and insoluble forms.
In the present study we also investigated the effect EGCG administration
had on tau pathology and cognition in Tg mice. Both i.p. and
orally-treated Tg animals were found to have modulated tau profiles,
with markedly suppressed sarkosyl-soluble phosphorylated tau isoforms.
Radial arm water maze (RAWM) testing for working memory indicated that
EGCG provided cognitive benefit to Tg mice with both i.p. and oral
administration, although i.p.-treated animals showed a more pronounced
benefit because of the greater impairment of their Tg controls at the
time of testing. Taken together, these data further the notion of EGCG
dietary supplementation as a potentially safe and effective prophylaxis
for Alzheimer's disease.
PMID: 18457818
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Since mice have a metabolic rate about 7 times faster than humans, the
human dose would be about 50/7 mg/Kg(human). For a 70 Kg human this
would be about 500 mg/day of egcg . From their 2005 study it was found
that for best results the egcg should be purified from the green tea.
Teavigo is a pure form of egcg --
http://www.iherb.com/ProductDetails.aspx?c=1&pid=4129
4 caps of teavigo will give 540 mg of egcg. It is best to take this with
water in divided doses. Avoid taking with milk as the milk protein
can bind with egcg. |
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