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Science Forum Index » Life Extension Forum » tomato extract lowers blood pressure...
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| Doug Skrecky... |
 Posted: Mon May 05, 2008 5:45 am |
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[The cheapest source of tomato antioxidants in most supermarkets is
canned crushed tomatoes.]
Am Heart J. 2006 Jan;151(1):100.
Natural antioxidants from tomato extract reduce blood pressure in patients
with grade-1 hypertension: a double-blind, placebo-controlled pilot study.
Engelhard YN, Gazer B, Paran E. Hypertension Unit, Faculty of Health
Sciences, Soroka University Medical Centre, Ben Gurion, University of the
Negev, 84101 Beer Sheva, Israel.
BACKGROUND: Treatment of hypertension (HT) can reduce the risk for
cardiovascular diseases. Tomato extract contains carotenoids such as
lycopene, beta carotene, and vitamin E, which are known as effective
antioxidants, to inactivate free radicals, and to slow the progression of
atherosclerosis. The purpose of our study was to evaluate the effect of
tomato extract on systolic and diastolic blood pressure in grade-1 HT, on
serum lipoproteins, plasma homocysteine, and oxidative stress markers.
METHODS: This study is a single-blind, placebo-controlled trial. Thirty-one
subject with grade-1 HT, without concomitant diseases, who required no
antihypertensive or lipid-lowering drug therapy, who were recruited from
primary care clinics, completed the trial. Subjects entered a 4-week placebo
period, then an 8-week treatment period with tomato extract, 250 mg
Lyc-O-Mato, and a 4-week control period with placebo. RESULTS: Systolic
blood pressure decreased from 144 (SE +/- 1.1) to 134 mm Hg (SE +/- 2, P <
..001), and diastolic blood pressure decreased from 87.4 (SE +/- 1.2) to 83.4
mm Hg (SE +/- 1.2, P < .05). No changes in blood pressure were demonstrated
during placebo periods. Thiobarbituric acid-reactive substances, a lipid
peroxidation products marker, decreased from 4.58 (SE +/- 0.27) to 3.81
nmol/mg (SE +/- 0.32, P < .05). No significant changes were found in lipid
parameters. CONCLUSIONS: A short-term treatment with antioxidant-rich tomato
extract can reduce blood pressure in patients with grade-1 HT, naive to drug
therapy. The continuous effect of this treatment and the long-term
beneficial effect on cardiovascular risk factors still need to be
demonstrated.
PMID: 16368299 |
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| trigonometry1972 at (no spam) gmail.com |... |
| Posted: Wed May 07, 2008 11:35 pm |
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Just a minor side comment:
Given the rate canned tomato products leak, I have
to wonder if one gets an extra large dose of can
lacquer chemicals from the aforesaid products.
Anyway, one does well to date such products with a felt tipped
pen and try to use such products promptly.
Glass is also preferred container, I'd think. |
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| trigonometry1972 at (no spam) gmail.com |... |
| Posted: Wed May 07, 2008 11:54 pm |
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Guest
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Here is another paper on the topic.
1: Ann Nutr Metab. 2007;51(5):477-81. Epub 2007 Nov 20.
Effect of lycopene from tomatoes (cooked) on plasma antioxidant
enzymes, lipid
peroxidation rate and lipid profile in grade-I hypertension.
Bose KS, Agrawal BK.
Department of Biochemistry,
People's College of Medical Sciences and Research Centre,
Bhanpur, India.
Subhashbose1 at (no spam) yahoo.co.in
BACKGROUND:
Results from observational studies suggest that the oxidative stress
and hyperlipidemic status, which prevails in hypertension, plays an
important
role in causation of secondary complications. So the aim of the
present study is
to evaluate the beneficial effect of tomatoes, which are a rich source
of
lycopene, a relatively new carotenoid known to play an important role
in human
health and disease.
METHODS:
In this study lipid peroxidation rate was measured
by estimating malondialdehyde (MDA) and the activity of
plasma enzymes involved in antioxidant activities like
superoxide dismutase (SOD), glutathione peroxidase
(GSH-Px), glutathione reductase (GR), reduced glutathione (GSH),
and serum lipid profile which includes total cholesterol
and triglycerides were estimated in a
grade I hypertensive group (n = 40) and
an age-matched control group (n = 50).
RESULTS:
Significantly lower plasma antioxidant enzyme activity,
very high lipid peroxidation rate and very high
serum total cholesterol, triglycerides in the
grade I hypertensive group was observed
when compared to the control group (p <
0.001). Sixty days of tomato supplementation
in the hypertensive group (n = 30)
showed a significant improvement in the
levels of serum enzymes involved in antioxidant activities
and decreased lipid peroxidation rate (F value highly
significant), but there were no significant changes in
lipid profile (F value insignificant).
CONCLUSION:
These findings suggest that tomato lycopene
may have considerable natural therapeutic
potential as an antioxidant but may not be used
as a hypolipidemic agent in hypertension.
(c) 2007 S. Karger AG, Basel.
PMID: 18025823 [PubMed - indexed for MEDLINE]
Related Links
Effect of lycopene from cooked tomatoes on serum antioxidant
enzymes, lipid
peroxidation rate and lipid profile in coronary heart disease.
[Singapore Med J.
2007] PMID:17453080
Effect of long term supplementation of tomatoes (cooked) on levels
of antioxidant
enzymes, lipid peroxidation rate, lipid profile and glycated
haemoglobin in Type
2 diabetes mellitus. [West Indian Med J. 2006] PMID:17249316
Effect of dietary n-3 and n-6 oils with and without food
restriction on activity
of antioxidant enzymes and lipid peroxidation in livers of
cyclophosphamide
treated autoimmune-prone NZB/W female mice. [J Am Coll Nutr. 2003]
PMID:14559931
Nitric oxide and lipid peroxidation are increased and associated
with decreased
antioxidant enzyme activities in patients with age-related macular
degeneration.
[Doc Ophthalmol. 2003] PMID:12678277
The evaluation of autoantibodies against oxidatively modified low-
density
lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids
and lipid
hydroperoxide levels, total antioxidant status, antioxidant enzyme
activities,
and endothelial dysfunction in patients with Behçet's disease. [Clin
Biochem.
2002] PMID:12074830 |
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