Hello,

Greetings!!

Can there be some instabilty or abnormality in intestinal mucus
generation which can interfere in normal absorption of glucose and
other nutrients (non-Cystic Fibrosis related) impacting on blood
levels?

Kumar wrote:
Hello,

Greetings!!

Can there be some instabilty or abnormality in intestinal mucus
generation which can interfere in normal absorption of glucose and
other nutrients (non-Cystic Fibrosis related) impacting on blood
levels?

Vitamin A deficiency increases mucus production in general. If excess
mucus production can interfere in normal absorption of glucose and other
nutrients I do not know. But since so much is interconnected in human
body, it may be worth looking into that.

--
Dawid Michalczykhttp://www.selfgrowth.com/experts/dawid_michalczyk.html

On Mar 14, 7:57 pm, Dawid Michalczyk <d...@eonworks.com> wrote:





Kumar wrote:
Hello,

Greetings!!

Can there be some instabilty or abnormality in intestinal mucus
generation which can interfere in normal absorption of glucose and
other nutrients (non-Cystic Fibrosis related) impacting on blood
levels?

Vitamin A deficiency increases mucus production in general. If excess
mucus production can interfere in normal absorption of glucose and other
nutrients I do not know. But since so much is interconnected in human
body, it may be worth looking into that.

--
Dawid Michalczykhttp://www.selfgrowth.com/experts/dawid_michalczyk.html

Thanks.

Three aspects can be thought;

1. Decreased absorption of glucose and other nutrients esp. big
molecules due to thick mucus layer in intestines.

2. Enhanced absorption due to trapping of nutrient's molecules in
intestinal mucus for prolonged time.

3. Decreased satiety of one or few nutrients due to decreased
absorption caused by thick intestinal mucus resulting continual and
excess cravings leading to overeating and increased levels in blood.

Its role in respiratory and reproductive system loos to be well
sutudied but in digestive tract--pancreas, intestines etc. look to be
not yet clear. Ingestion of phelgum and post nasal drips in few
patients can also have some relevance. Mucolytic and mucus forming
agents an cystic fibrosis, mucus in stool can be checked for this
purpose.- Hide quoted text -

- Show quoted text -

On Mar 15, 12:00 pm, Kumar <lordshiva5...@gmail.com> wrote:





On Mar 14, 7:57 pm, Dawid Michalczyk <d...@eonworks.com> wrote:

Kumar wrote:
Hello,

Greetings!!

Can there be some instabilty or abnormality in intestinal mucus
generation which can interfere in normal absorption of glucose and
other nutrients (non-Cystic Fibrosis related) impacting on blood
levels?

Vitamin A deficiency increases mucus production in general. If excess
mucus production can interfere in normal absorption of glucose and other
nutrients I do not know. But since so much is interconnected in human
body, it may be worth looking into that.

--
Dawid Michalczykhttp://www.selfgrowth.com/experts/dawid_michalczyk.html

Thanks.

Three aspects can be thought;

1. Decreased absorption of glucose and other nutrients esp. big
molecules due to thick mucus layer in intestines.

2. Enhanced absorption due to trapping of nutrient's molecules in
intestinal mucus for prolonged time.

3. Decreased satiety of one or few nutrients due to decreased
absorption caused by thick intestinal mucus resulting continual and
excess cravings leading to overeating and increased levels in blood.

Its role in respiratory and reproductive system loos to be well
sutudied but in digestive tract--pancreas, intestines etc. look to be
not yet clear. Ingestion of phelgum and post nasal drips in few
patients can also have some relevance. Mucolytic and mucus forming
agents an cystic fibrosis, mucus in stool can be checked for this
purpose.- Hide quoted text -

- Show quoted text -

I am not sure, whether pepsin and other protease enzyme by their
proeolysis and mcolytic action can break down mucus and nutralize
effectiveness of thick or excess mucus in digestive tract. If so, some
abnormality in digestive enzymes can also be responible for intestinal
mucus. Do anyone know about it?

I read in one drug index, one cough mixture claiming to increase
effectiveness of antibiotics by mucosupperessive, mucolytic and
mucokinetic action of cough syrup. Ths can address my thoughts about
possible link of intestinal mucus with absorption. ??- Hide quoted text -

- Show quoted text -

Can there be some instabilty or abnormality in intestinal mucus
generation which can interfere in normal absorption of glucose and
other nutrients (non-Cystic Fibrosis related) impacting on blood
levels?

Can there be some instabilty or abnormality in intestinal mucus
generation which can interfere in normal absorption of glucose and
other nutrients (non-Cystic Fibrosis related) impacting on blood
levels?

Yes.  When you lose gut barrier function, you can get undigested food
coming into contact with the immune system.  The resulting
inflammation/autoimmunity can further damage angiogenesis and cause
nutritional deficiency.

This happens through several routes.  In many autoimmune gut conditions,
butyrate uptake is defective.  Without butyrate (and enough carnitine to
properly metabolize it), you lose the histone acetylation you need to
make more mucous (via mucin genes).  Turns out vitamin D3 also needs
histone acetylation to make the innate antimicrobial peptide
cathelicidin which is vital for gut barrier function - and it just so
happens cathelicidin has antiinflammatory/antiallergy properties.  
(HIF-1a is a crucial intermediary gene in this chain.)

Since symbiotic bacteria living in the gut produce butyrate from
undigested fiber, you can set this whole ugly process in motion by
taking antibiotics long enough - especially if you combine it with a
crappy American diet rich in sugar and low in fiber.

This may cause, normal and abnormal motility, digestion and
absorptions of food. One one side, there can be normacy whereas
defficiencies or decreased satiety OR excesses on other side. How it
can be related to excessive cravings, decreased hunger and abnormal
digestion, motality and absorptions in intestines?

This may cause, normal and abnormal motility, digestion and
absorptions of food. One one side, there can be normacy whereas
defficiencies or decreased satiety OR excesses on other side. How it
can be related to excessive cravings, decreased hunger and abnormal
digestion, motality and absorptions in intestines?

I think you're asking about how mucous thickness affects the transit
time of food through the gut and how that time affects feelings of
hunger or fullness.  The answer is, I haven't looked at it like that.  I
do know the mu opioid receptor can get screwed up in the gut, which is
why low-dose naltrexone is helpful and why morphine affects gut transit
time.  The mu opioid receptor is under control of butyrate via HDAC
inhibition and thus under control of probiotics.

Hunger itself is regulated by peptide hormones secreted from the gut
lining running back and forth to the brain.  Excess hunger can be curbed
by eliminating part of the gut producing those hunger signals - i.e.,
gastric stapling.  There's literally less stomach around to produce
hunger signals and send "feel hungry" signals to the brain after the
surgery.
Can't decreased satiety due to decreased absorptions as a result of

Since I came across research indicating obese people are more likely to
have certain viral infections and another abstract indicating the
existence of autoantibodies to hunger hormones, it's possible that
certain obese patients are simply autoimmune to their own fullness
hormone signals.  Guy gets food-borne virus.  Virus shares a protein
sequence with leptin or ghrelin or a PYY.  Immune system attacks that
sequence to eliminate the virus but ends up eliminating the "full"
signal, thus causing the poor guy to overeat the very food that has the
virus.  Smart strategy for the virus, hell for the autoimmune guy.
Thanks, this is good research. It may also indicate, a biochemical

Finally, stress and lack of sleep enhance hunger for sweet, salty and
fatty foods so problems in the HPA stress axis or in circadian rhythms
can affect hunger levels - which isn't surprising since the central
circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.  
Mutations in Clock and elsewhere along the clock pathway can affect
general cravings for a wide range of addictions like cocaine.

I think you're asking about how mucous thickness affects the transit
time of food through the gut and how that time affects feelings of
hunger or fullness.  The answer is, I haven't looked at it like that.  I
do know the mu opioid receptor can get screwed up in the gut, which is
why low-dose naltrexone is helpful and why morphine affects gut transit
time.  The mu opioid receptor is under control of butyrate via HDAC
inhibition and thus under control of probiotics.

I am also looking at decreased digestion & absorption of all or few
nutrients due to altered mucus resulting decreased satiety & hunger/
craving to eat more.

Finally, stress and lack of sleep enhance hunger for sweet, salty and
fatty foods so problems in the HPA stress axis or in circadian rhythms
can affect hunger levels - which isn't surprising since the central
circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.  
Mutations in Clock and elsewhere along the clock pathway can affect
general cravings for a wide range of addictions like cocaine.

It is also good findings and may be relevant to modern/big cities
changed life-style with chronic stress, late sleep etc.

Btw, whether it is lack of sleep or late sleep & late getting up
resulting altered light exposures?

I think you're asking about how mucous thickness affects the transit
time of food through the gut and how that time affects feelings of
hunger or fullness. The answer is, I haven't looked at it like that. I
do know the mu opioid receptor can get screwed up in the gut, which is
why low-dose naltrexone is helpful and why morphine affects gut transit
time. The mu opioid receptor is under control of butyrate via HDAC
inhibition and thus under control of probiotics.
I am also looking at decreased digestion & absorption of all or few
nutrients due to altered mucus resulting decreased satiety & hunger/
craving to eat more.

You're interested in the barrier function literature and it's not
primarily focused on mucous so that's not going to get you very far.
You're looking for work on tight gap junction proteins like zonulin and
the recent stuff on HIF-1/vitamin D. Barrier dysfunction will affect
nutritional absorption. Malnutrition can enhance or lower your appetite
depending on what part of your metabolism takes a hit.


Finally, stress and lack of sleep enhance hunger for sweet, salty and
fatty foods so problems in the HPA stress axis or in circadian rhythms
can affect hunger levels - which isn't surprising since the central
circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.
Mutations in Clock and elsewhere along the clock pathway can affect
general cravings for a wide range of addictions like cocaine.
It is also good findings and may be relevant to modern/big cities
changed life-style with chronic stress, late sleep etc.

Btw, whether it is lack of sleep or late sleep & late getting up
resulting altered light exposures?

I don't know exactly what you're asking but it's easily remedied in part
by sleeping with something covering your eyes to minimize your light
exposure.

I think you're asking about how mucous thickness affects the transit
time of food through the gut and how that time affects feelings of
hunger or fullness.  The answer is, I haven't looked at it like that..  I
do know the mu opioid receptor can get screwed up in the gut, which is
why low-dose naltrexone is helpful and why morphine affects gut transit
time.  The mu opioid receptor is under control of butyrate via HDAC
inhibition and thus under control of probiotics.

I am also looking at decreased digestion & absorption of all or few
nutrients due to altered mucus resulting decreased satiety & hunger/
craving to eat more.

You're interested in the barrier function literature and it's not
primarily focused on mucous so that's not going to get you very far.  
You're looking for work on tight gap junction proteins like zonulin and
the recent stuff on HIF-1/vitamin D.  Barrier dysfunction will affect
nutritional absorption.  Malnutrition can enhance or lower your appetite
depending on what part of your metabolism takes a hit.

Finally, stress and lack of sleep enhance hunger for sweet, salty and
fatty foods so problems in the HPA stress axis or in circadian rhythms
can affect hunger levels - which isn't surprising since the central
circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.  
Mutations in Clock and elsewhere along the clock pathway can affect
general cravings for a wide range of addictions like cocaine.

It is also good findings and may be relevant to modern/big cities
changed life-style with chronic stress, late sleep etc.

Btw, whether it is lack of sleep or late sleep & late getting up
resulting altered light exposures?

I don't know exactly what you're asking but it's easily remedied in part
by sleeping with something covering your eyes to minimize your light
exposure.

Kofi wrote:
I think you're asking about how mucous thickness affects the transit
time of food through the gut and how that time affects feelings of
hunger or fullness.  The answer is, I haven't looked at it like that..  I
do know the mu opioid receptor can get screwed up in the gut, which is
why low-dose naltrexone is helpful and why morphine affects gut transit
time.  The mu opioid receptor is under control of butyrate via HDAC
inhibition and thus under control of probiotics.
I am also looking at decreased digestion & absorption of all or few
nutrients due to altered mucus resulting decreased satiety & hunger/
craving to eat more.

You're interested in the barrier function literature and it's not
primarily focused on mucous so that's not going to get you very far.  
You're looking for work on tight gap junction proteins like zonulin and
the recent stuff on HIF-1/vitamin D.  Barrier dysfunction will affect
nutritional absorption.  Malnutrition can enhance or lower your appetite
depending on what part of your metabolism takes a hit.

Finally, stress and lack of sleep enhance hunger for sweet, salty and
fatty foods so problems in the HPA stress axis or in circadian rhythms
can affect hunger levels - which isn't surprising since the central
circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.  
Mutations in Clock and elsewhere along the clock pathway can affect
general cravings for a wide range of addictions like cocaine.
It is also good findings and may be relevant to modern/big cities
changed life-style with chronic stress, late sleep etc.

Btw, whether it is lack of sleep or late sleep & late getting up
resulting altered light exposures?

I don't know exactly what you're asking but it's easily remedied in part
by sleeping with something covering your eyes to minimize your light
exposure.

Don't confuse mucus (the noun) with mucous (the adjective).

--
Marshall Price of Miami
Known to Yahoo as d021317c- Hide quoted text -

- Show quoted text -