| |
 |
|
|
Science Forum Index » Medicine - Nutrition Forum » Brain-permeable natural iron chelators
Page 1 of 1
|
| Author |
Message |
| ironjustice |
 Posted: Mon Feb 05, 2007 10:54 pm |
|
|
|
Guest
|
Would shooting this back with wee bit of .. lecithin.. and its'
nutrient absorption enhancing properties BE even MORE ..
beneficial .. ?
Mol Nutr Food Res. 2006 Feb;50(2):229-34. Links
Green tea catechins as brain-permeable, natural iron chelators-
antioxidants for the treatment of neurodegenerative disorders.
Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MB.
Eve Topf, Haifa, Israel. mandel@tx.technion.ac.il
Neurodegeneration in Parkinson's, Alzheimer's, or other
neurodegenerative diseases appears to be multifactorial, where a
complex set of toxic reactions, including oxidative stress (OS),
inflammation, reduced expression of trophic factors, and accumulation
of protein aggregates, lead to the demise of neurons. One of the
prominent pathological features is the abnormal accumulation of iron
on top of the dying neurons and in the surrounding microglia. The
capacity of free iron to enhance and promote the generation of toxic
reactive oxygen radicals has been discussed numerous times. The
observations that iron induces aggregation of inert alpha-synuclein
and beta-amyloid peptides to toxic aggregates have reinforced the
critical role of iron in OS-induced pathogenesis of neurodegeneration,
supporting the notion that a combination of iron chelation and
antioxidant therapy may be one significant approach for
neuroprotection. Tea flavonoids (catechins) have been reported to
possess divalent metal chelating, antioxidant, and anti-inflammatory
activities, to penetrate the brain barrier and to protect neuronal
death in a wide array of cellular and animal models of neurological
diseases. This review aims to shed light on the multipharmacological
neuroprotective activities of green tea catechins with special
emphasis on their brain-permeable, nontoxic, transitional metal (iron
and copper)-chelatable/radical scavenger properties.
PMID: 16470637 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------
<<snip>>
one molecule is capable of reducing up to four iron(III) species
<<snip>>
The kinetics and mechanisms of the complex formation and antioxidant
behaviour of the polyphenols EGCg and ECG with iron(III).
Ryan P, Hynes MJ
J Inorg Biochem. 2006 Dec 12;
(-)-Epigallocatechin-gallate ((-)-EGCg) and (-)-epicatechin-gallate
((-)-ECG) are important antioxidants which are found in green tea.
The
kinetics and mechanisms of the reactions of a pseudo-first order
excess of iron(III) with EGCg and ECG have been investigated in
aqueous solution at 25 degrees C and an ionic strength of 0.5M
NaClO(4). Mechanisms have been proposed which account satisfactorily
for the kinetic data. These are consistent with a mechanism in which
the 2:1 metal:ligand complex initially formed on reaction of
iron(III)
with the ligand subsequently decomposes in an electron transfer step.
Complex formation takes place at two separate binding sites via
coupled reactions. Rate constants of 4.28(+/-0.06)x10(6)M(-2)s(-1)
and
2.83(+/-0.04)x10(6)M(-2)s(-1) have been evaluated for the reaction of
monohydroxy Fe(OH)(2+) species with EGCg and ECG, respectively while
rate constants for of 2.94(+/-0.4)x10(4)M(-2)s(-1) and
2.41(+/-0.25)x10(4)M(-2)s(-1) have been evaluated for the reaction of
Fe(3+) species with EGCg and ECG, respectively. The iron(III)
assisted
decomposition of the initial iron(III) complex formed was also
investigated and the rate constants evaluated. Both the complex
formation and subsequent electron transfer reactions of iron(III)
with
EGCg and ECG were monitored using UV-visible spectrophotometry. All
of
the suggested mechanisms and calculated rate constants are supported
by calculations carried out using global analysis of time dependant
spectra. The results obtained show that one molecule of either EGCg
or
EGC is capable of reducing up to four iron(III) species, a fact which
is consistent with the powerful antioxidant properties of the
ligands.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
|
|
| Back to top |
|
| GreatArtist |
| Posted: Mon Feb 05, 2007 11:11 pm |
|
|
|
Guest
|
I believe alpha lipoic acid chelates iron and can pass the blood brain
barrier. |
|
|
| Back to top |
|
| |
|
Page 1 of 1
All times are GMT - 5 Hours
The time now is Fri Dec 05, 2008 1:20 am
|
|