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Science Forum Index » Medicine - Nursing Forum » Arthritis / oxidative stress
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| ironjustice |
 Posted: Fri Jan 05, 2007 12:51 am |
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[The role of oxidative stress in the etiopathogenesis of rheumatoid
arthritis]
Matyska-Piekarska E, Luszczewski A, Lacki J, Wawer I
Postepy Hig Med Dosw (Online). 2006; 60: 617-23
Numerous scientific investigations confirmed the occurrence of
oxidative stress in rheumatoid arthritis patients. There is evidence
demonstrating elevated levels of oxidative stress markers and oxidative
damage caused by reactive oxygen species (ROS) to lipids, proteins,
sugars, and DNA, as well as a significant decrease in total antioxidant
capacity, which protects the organism against ROS activity. Extensive
ROS production can significantly accelerate the process of articular
cartilage damage. It is believed that many disease-modifying
anti-rheumatic drugs (DMARDs) affect oxidative stress, although there
has been insufficient research to confirm such a relationship.
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Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and
antioxidant enzymes in patients with osteoarthritis.
Surapaneni KM, Venkataramana G
Indian J Med Sci. 2007 Jan ; 61(1): 9-14
BACKGROUND: The exact pro-oxidant and antioxidant status in
osteoarthritis patients is still not clear. To add a new insight to the
question, changes in the erythrocyte lipid peroxidation products (MDA),
levels of glutathione (GSH), ascorbic acid and plasma vitamin E
(nonenzymatic antioxidant parameters); and activities of antioxidant
enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX),
catalase in erythrocytes and plasma glutathione - S - transferase (GST)
were measured in patients with osteoarthritis. AIM: This work was
undertaken to assess oxidative stress and antioxidant status in
patients with osteoarthritis. SETTINGS AND DESIGN: The study was
conducted in 20 patients and compared to controls. Levels of
erythrocyte MDA, GSH, ascorbic acid, plasma vitamin E; and activities
of antioxidant enzymes were measured in patients with osteoarthritis.
materials and Methods: Erythrocyte GSH was measured by the method of
Beutler et al. Ascorbic acid levels were measured by the method of
Tietz. Plasma vitamin E levels were measured by the method of Baker et
al. MDA was determined as the measure of thio barbituric acid reactive
substances (TBARS). SOD activity in the hemolysate was measured by the
method of Misra and Fridovich. Activity of catalase was measured by the
method of Beers and Sizer. GPX activity was measured as described by
Paglia and Valentine in erythrocytes and Plasma GST activity was
measured as described by Warholm et al. These parameters were measured
in 20 patients and compared to controls. STATISTICAL ANALYSIS:
Statistical analysis between group 1 (controls) and group 2 (patients)
was performed by the student's t - test using the stat -view package.
Results: It was observed that there was a significant increase in
erythrocyte MDA levels; SOD, GPX and plasma GST activities; and a
significant decrease in erythrocyte GSH, ascorbic acid, plasma vitamin
E levels and catalase activity in patients with osteoarthritis when
compared to controls. CONCLUSIONS: The results of our study suggest
higher oxygen-free radical production, evidenced by increased MDA and
decreased GSH, ascorbic acid, vitamin E and catalase activity, support
to the oxidative stress in osteoarthritis. The increased activities of
antioxidant enzymes may be a compensatory regulation in response to
increased oxidative stress.
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