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Science Forum Index » Medicine - Nursing Forum » Blood viscosity / heart disease
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| ironjustice@aol.com |
 Posted: Tue Dec 19, 2006 7:31 pm |
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Blood is thicker than water: the management of hyperviscosity in adults
with cyanotic heart disease.
DeFilippis AP, Law K, Curtin S, Eckman JR
Cardiol Rev. 2007 Jan-Feb ; 15(1): 31-4
Complications of chronic hypoxia, including erythrocytosis,
hyperviscosity, abnormalities of hemostasis, cerebral abscesses,
stroke, and endocarditis, are among the most common consequences of
cyanotic heart disease in adults. The compensatory erythrocytosis of
cyanotic heart disease can become pathologic by causing an increase in
blood viscosity, thereby decreasing perfusion and resulting in
decreased total oxygen delivery and increased risk of
venoocclusive/hyperviscosity syndrome. Treatment of hyperviscosity
secondary to erythrocytosis in cyanotic heart disease is controversial.
Data is limited but suggest that phlebotomy has the potential to
increase exercise capacity, reduce the symptoms of hyperviscosity, and
reduce the potential risk of vasoocclusive disease in selected patients
with polycythemia secondary to cyanotic heart disease. Unfortunately,
repeated phlebotomy can quickly lead to iron deficiency, resulting in
microcytic erythrocytes that induce higher viscosity than normocytic
erythrocytes, which may increase the risk for venoocclusive events.
There are limited data on the use of hydroxyurea to suppress
erythrocytosis in this patient population. The authors conclude that
until newer approaches to decreasing hematocrit without inducing iron
deficiency are shown to be safe and efficacious, phlebotomy should only
be used for the acute resolution of hyperviscosity symptoms. In
addition, the use of hydroxyurea should be limited to patients with
recurrent symptoms.
Abstract · PubMed FullText · SFX · GS Clip Export InterDB ·
Terms Related · Graph Tag · Scopus · Cites
10.1097/01.crd.0000214959.82120.97
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| ironjustice@aol.com |
| Posted: Fri Dec 22, 2006 7:12 pm |
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Guest
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Quote: The authors conclude that
until newer approaches to decreasing hematocrit without inducing iron
deficiency are shown to be safe and efficacious, phlebotomy should
only
be used for the acute resolution of hyperviscosity symptoms. In
addition, the use of hydroxyurea should be limited to patients with
recurrent symptoms.<<
It seems bloodletting {modern day bloodletting / hemodilution] combined
with a drug .. pentoxifylline .. which ..'coincidentally' .. lowers
red blood cell count {again modern day bloodletting / medicinal
bloodletting] .. HAS been shown to BE effective in lowering ..
viscosity .. therefore .. theoretically .. prolonging .. ones' ..
length of life ..
<<snip>>
elevated plasma viscosity was lowered by haemodilution therapy
<<snip>>
[Hemodilution therapy in patients with acute anterior ischemic optic
neuropathy]
Wolf S, Schulte-Strake U, Bertram B, Schulte K, Arend O, Reim M
Ophthalmologe. 1993 Feb ; 90(1): 21-6
A prospective study was performed in 22 patients with an anterior
ischaemic optic neuropathy (AION). All patients underwent iso- (Hct >
or = 42%) or hypervolemic (Hct < 42%) haemodilution for 10 days with
daily infusion of 250 ml hydroxyethyl starch (MW 200,000/0.5, 10%
HAES-sterile) in combination with pentoxifylline (p.o.: 1200 mg/day;
i.v.: 300 mg/day; Trental). Only patients with recent AION (less than 2
weeks' duration of symptoms) were considered for the prospective trial.
Clinical, haemodynamic (arterio-venous passage time) and rheological
(haematocrit, plasma viscosity, erythrocyte aggregation) data of all
patients were recorded before therapy and after 10 days. An improvement
of central vision by 2 or more lines was seen in 7 patients after 10
days. Initially the arterio-venous passage time was significantly
prolonged in patients (2.42 +/- 0.7 s) with AION compared with healthy
volunteers (1.45 +/- 0.4 s). After the 10-day trial arterio-venous
passage time was significantly shorter than baseline values. In
addition, the initially elevated plasma viscosity (1.33 +/- 0.1 mPa)
was significantly lowered by haemodilution therapy.
Abstract · PubMed FullText · SFX · GS Clip Export InterDB ·
Terms Related · Graph Tag · Cites
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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