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Science Forum Index » Medicine - Cancer Forum » Ixabepilone (BMS-247550, NSC 710428), an analog of epothilon
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| J |
 Posted: Tue Dec 12, 2006 8:04 pm |
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http://bethesdatrials.cancer.gov/kidney/nci02c0130/drug_types.html
Ixabepilone (BMS-247550, NSC 710428), an analog of epothilone B, is a
novel chemotherapeutic agent that stabilizes the microtubules of dividing
cells, resulting in death of the cell. Ixabepilone works in a similar
manner to another class of drugs, the taxanes (e.g. paclitaxel,
docetaxel), which are currently in use in a variety of cancers. However,
ixabepilone has been shown to be more potent in laboratory and human
studies, may have fewer side effects, and is not as prone to tumor
resistance as the taxanes.
http://www.clinicaltrials.gov/ct/show/NCT00397072
Epothilone in Recurrent Glioblastoma Patients
This study is currently recruiting patients.
Verified by Istittuto Nazionale Neurologico Carlo Bestaq November 2006
The purpose of this single arm phase II study is to evaluate safety and
efficacy of ZK 219477 in the treatment of temozolomide pre-treated,
recurrent GBM patients.
Official Title: Phase II Study: Systemic Treatment With iv
ZK219477-Epothilone in Recurrent Glioblastoma Patients |
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