Main Page | Report this Page
 
   
Science Forum Index  »  Life Extension Forum  »  1% topical viagra has no effect on alopecia areata
Page 1 of 1    
Author Message
Kofi
Posted: Tue Oct 17, 2006 10:44 pm
Guest
J Dermatolog Treat. 2006;17(4):235-7. Related Articles, Links
Click here to read
Determination of the sildenafil effect on alopecia areata in
childhood: An open-pilot comparison study.

Sarifakioglu E, Tuncer Degim I, Gorpelioglu C.

Department of Dermatology, Faculty of Medicine, Fatih University,
Ankara, Turkey.

Background: Alopecia areata is an immunologically mediated cessation
of hair growth primarily involving, but not limited to, the scalp. The
treatment of alopecia areata involves promotion of hair growth (for
instance with topical minoxidil application), immunosuppression
(intralesional or systemic steroid therapy, phototherapy) or
immunomodulation (anthralin, dinitrochlorobenzene,
diphenylcyclopropenone, squaric acid dibutylester). All these
medications have some disadvantages and difficulties for the treatment
of children with alopecia areata. Objective: To use an open-pilot study
to assess the efficacy of topical 1% sildenafil in children diagnosed
with alopecia areata. Methods: Eight patients with (25% of scalp surface
area involvement) alopecia areata who were refractory to previous
topical treatments applied 1% sildenafil twice daily for 3 months. All
the patients completed the study. Results: Two patients experienced
vellus-type hair growth and one patient had terminal hair growth.
However, these outcomes were accepted as the spontaneous regression of
the disease. Conclusion: We cannot recommend the use of topical 1%
sildenafil for the treatment of alopecia areata without further evidence
of its therapeutic benefit.

PMID: 16971319 [PubMed - in process]
T
Posted: Wed Oct 18, 2006 3:23 pm
Guest
Koli,

Why should this come as a surprise? There are a slew of NO destroyers. The
ED drugs are specific to PDE-5 inhibitors. There are many other PDE
inhibitors. The ED drugs have slight to no effect on the other PDE
inhibitors which destroy NO in other organ systems. Viagra, Cialis and the
lot effect the penis and to some degree the circularatory system. Threre's
a 1:32,000 effect on the PDE which is active in the retina versus the penis.
Why would we expect ED drugs to necessarily effect baldness? Because
Minoxidil works on the scalp and Viagra works a little on the circulatory
system?

The Japanese report a new cure for baldness every week. We don't we just
stick with one of those? Smile
Chuck
Posted: Thu Oct 19, 2006 12:19 pm
Guest
T wrote:
Quote:
Koli,

Why should this come as a surprise? There are a slew of NO destroyers. The
ED drugs are specific to PDE-5 inhibitors. There are many other PDE
inhibitors. The ED drugs have slight to no effect on the other PDE
inhibitors which destroy NO in other organ systems. Viagra, Cialis and the
lot effect the penis and to some degree the circularatory system. Threre's
a 1:32,000 effect on the PDE which is active in the retina versus the penis.
Why would we expect ED drugs to necessarily effect baldness? Because
Minoxidil works on the scalp and Viagra works a little on the circulatory
system?

The Japanese report a new cure for baldness every week. We don't we just
stick with one of those? Smile

Is there *really* anything new in hairloss though? That is practical
and ready for use? I still use finasteride and Nizoral. I actually did
some research of my own with nano shampoo and I most certainly, without
a doubt, *did* get some benefit. Other than that, what is there?
T
Posted: Thu Oct 19, 2006 5:23 pm
Guest
"Chuck" <chuckfrasher@gmail.com> wrote in message
news:1161271168.523387.108890@e3g2000cwe.googlegroups.com...
Quote:

T wrote:
Koli,

Why should this come as a surprise? There are a slew of NO destroyers.
The
ED drugs are specific to PDE-5 inhibitors. There are many other PDE
inhibitors. The ED drugs have slight to no effect on the other PDE
inhibitors which destroy NO in other organ systems. Viagra, Cialis and
the
lot effect the penis and to some degree the circularatory system.
Threre's
a 1:32,000 effect on the PDE which is active in the retina versus the
penis.
Why would we expect ED drugs to necessarily effect baldness? Because
Minoxidil works on the scalp and Viagra works a little on the
circulatory
system?

The Japanese report a new cure for baldness every week. We don't we
just
stick with one of those? :-)

Is there *really* anything new in hairloss though? That is practical
and ready for use? I still use finasteride and Nizoral. I actually did
some research of my own with nano shampoo and I most certainly, without
a doubt, *did* get some benefit. Other than that, what is there?


The OzBrew worked for me. Did it bring me back the hair of my youth? No.
The weekly discoveries made by the Japanese always work on a percentage of
the people.

Is there really anything that works? Well, let's just say that the discover
and promotor of the OzBrew closed his personal Usenet server offering
discussion the OzBrew when he finally decided to get yet another hair
transplant (the previous ones failed) and it took. No. If you want to be
cured of cancer, aging, HIV and a host of other things, be yeast, mold, a
fruitfly, a mouse or a monkey. We're extremely good at giving these most
anything and getting a positive response. Failing that, we breed them to be
bald or get cancer or an analog to HIV then we cure what we bred into them.
It was said at least 20 years ago that more scientists were alive then than
had lived in all of history. Regrettably, most of them are doing junk
research.
Chuck
Posted: Fri Oct 20, 2006 11:25 am
Guest
Thanks for letting me know about the OzBrew. I was on the original news
group when he first broke away from baldspot. I still belong to an msn
group where guys are ordering thyroid hormone and stuff but I never
read it. I guess I'll hear about it if something spectacular happens.
Thanks, Chuck

T wrote:
Quote:
"Chuck" <chuckfrasher@gmail.com> wrote in message
news:1161271168.523387.108890@e3g2000cwe.googlegroups.com...

T wrote:
Koli,

Why should this come as a surprise? There are a slew of NO destroyers.
The
ED drugs are specific to PDE-5 inhibitors. There are many other PDE
inhibitors. The ED drugs have slight to no effect on the other PDE
inhibitors which destroy NO in other organ systems. Viagra, Cialis and
the
lot effect the penis and to some degree the circularatory system.
Threre's
a 1:32,000 effect on the PDE which is active in the retina versus the
penis.
Why would we expect ED drugs to necessarily effect baldness? Because
Minoxidil works on the scalp and Viagra works a little on the
circulatory
system?

The Japanese report a new cure for baldness every week. We don't we
just
stick with one of those? :-)

Is there *really* anything new in hairloss though? That is practical
and ready for use? I still use finasteride and Nizoral. I actually did
some research of my own with nano shampoo and I most certainly, without
a doubt, *did* get some benefit. Other than that, what is there?


The OzBrew worked for me. Did it bring me back the hair of my youth? No.
The weekly discoveries made by the Japanese always work on a percentage of
the people.

Is there really anything that works? Well, let's just say that the discover
and promotor of the OzBrew closed his personal Usenet server offering
discussion the OzBrew when he finally decided to get yet another hair
transplant (the previous ones failed) and it took. No. If you want to be
cured of cancer, aging, HIV and a host of other things, be yeast, mold, a
fruitfly, a mouse or a monkey. We're extremely good at giving these most
anything and getting a positive response. Failing that, we breed them to be
bald or get cancer or an analog to HIV then we cure what we bred into them.
It was said at least 20 years ago that more scientists were alive then than
had lived in all of history. Regrettably, most of them are doing junk
research.
T
Posted: Fri Oct 20, 2006 6:04 pm
Guest
"Chuck" <chuckfrasher@gmail.com> wrote in message
news:1161354325.985275.223980@m7g2000cwm.googlegroups.com...
Quote:
Thanks for letting me know about the OzBrew. I was on the original news
group when he first broke away from baldspot. I still belong to an msn
group where guys are ordering thyroid hormone and stuff but I never
read it. I guess I'll hear about it if something spectacular happens.
Thanks, Chuck


There was one rather obnoxious poster on that private Usenet group who added
T3 to his OzBrew. A bunch of us asked where he got it from. He didn't
respond. I don't recall him ever telling us that he was getting spectacular
results with the OzBrew. I was one of the people who did get rather good
results from the OzBrew, but as usual I went overboard. I did the peel for
something like once an hour for 2 weeks and used extra amounts of MSM and
L-Arginine in my OzBrew. I was working from home so was able to apply the
OzBrew much more often than most of the group members.
Chuck
Posted: Sat Oct 21, 2006 10:24 am
Guest
T wrote:
Quote:
"Chuck" <chuckfrasher@gmail.com> wrote in message
news:1161354325.985275.223980@m7g2000cwm.googlegroups.com...
Thanks for letting me know about the OzBrew. I was on the original news
group when he first broke away from baldspot. I still belong to an msn
group where guys are ordering thyroid hormone and stuff but I never
read it. I guess I'll hear about it if something spectacular happens.
Thanks, Chuck


There was one rather obnoxious poster on that private Usenet group who added
T3 to his OzBrew. A bunch of us asked where he got it from. He didn't
respond. I don't recall him ever telling us that he was getting spectacular
results with the OzBrew. I was one of the people who did get rather good
results from the OzBrew, but as usual I went overboard. I did the peel for
something like once an hour for 2 weeks and used extra amounts of MSM and
L-Arginine in my OzBrew. I was working from home so was able to apply the
OzBrew much more often than most of the group members.

I am glad that you got good results. But did they last? To maintain
your gains do you have to keep up with that intensity? I never acually
tried it because I kind of scared me. All that peeling and stuff, I
mean.
T
Posted: Sat Oct 21, 2006 1:09 pm
Guest
"Chuck" <chuckfrasher@gmail.com> wrote in message
news:1161437068.246441.326320@b28g2000cwb.googlegroups.com...
Quote:


I am glad that you got good results. But did they last? To maintain
your gains do you have to keep up with that intensity? I never acually
tried it because I kind of scared me. All that peeling and stuff, I
mean.


My gains have held. Oz seems to have found something here with the concept
of "the peel". Of course my hair is not as thick and full as it was when I
was on the OzBrew because the strands were coated with Minoxidil, MSM,
L-Arginine and other such. Brushing my hair with the OzBrew in it was a
pretty labor intensive chore and lots of crystals shed in all directions.
Remember Oz's forumla for hair thickener? MSM in a little water?

Will my hair die off again? Well, was using the new 15% Minox but haven't
used it in a while. Perhaps the hair will go dormant again. If it does, I
still have a folder in my Outlook Express for OzBrew. I've got the formula
Oz used and the one I used. I'll go back to the peel then the treatment
again. I have a suspicion, based on pure intuition that a second round will
not be necessary. Somebody, somewhere, will find an off label use of a drug
(as was first done with Minoxidil) or food supplement that will bring back
hair within the next few years. Reliably.

I've worked in Science. I'm trained in Science and research. I have so very
little respect for its plodding along, as do many drug companies, who are
taking every mold, mineral, herb, spice, vegetable extract, eye of newt and
testing them all for medicinal properties. Penicillin was discovered by a
scientist who actually was curious about what caused his culture to go bad.
Take all the "discoveries" that are being made these days with respect to
food. Suddenly scientists are finding that food is good for you. That the
food and spices used in Indian and Oriental cooking aren't just there
because they balance Yin and Yang or the 3 doshas. It comes to pass that
Yin, Yang and the 3 doshas are merely ways of describing very powerful
medicinal effects. The food manufacturers are going wild. When I buy
Hershey's cocoa, there's a big pitch on the box about its anti-oxident
properties. Will tumeric be next? Will we find out that baldness is
actually caused by a type of bacteria, curable with an antibiotic? It
worked for ulcers. It's working for lots of cancers. I wouldn't be
surprised at all if all the pathways and mechanisms that have been
discovered about hair growth and loss is suddenly blown away by the
discovery that there's a yet unknown cause and simple cure.
Nomen Nescio
Posted: Sat Oct 21, 2006 3:21 pm
Guest
Uh oh, this is going to get the idiot ranting.
Chuck
Posted: Sun Oct 22, 2006 3:36 pm
Guest
I think it would be great if hairloss could be cured by identifying
some simple unknown mechanism. I have been taking finasteride for about
12 years now and I took spironolactone for 2 years prior to that. Years
ago, I thought I would be bald by now but I still have a good bit of
hair on top. So I think that blocking the effects of DHT early on does
have an effect. But I sometimes wonder if there is something else going
on, but who knows.

I am surprised that you have achieved some long term results with the
OzBrew. Maybe that peeling and that damage stimulates a renewal of the
follicles or something.

T wrote:
Quote:
"Chuck" <chuckfrasher@gmail.com> wrote in message
news:1161437068.246441.326320@b28g2000cwb.googlegroups.com...


I am glad that you got good results. But did they last? To maintain
your gains do you have to keep up with that intensity? I never acually
tried it because I kind of scared me. All that peeling and stuff, I
mean.


My gains have held. Oz seems to have found something here with the concept
of "the peel". Of course my hair is not as thick and full as it was when I
was on the OzBrew because the strands were coated with Minoxidil, MSM,
L-Arginine and other such. Brushing my hair with the OzBrew in it was a
pretty labor intensive chore and lots of crystals shed in all directions.
Remember Oz's forumla for hair thickener? MSM in a little water?

Will my hair die off again? Well, was using the new 15% Minox but haven't
used it in a while. Perhaps the hair will go dormant again. If it does, I
still have a folder in my Outlook Express for OzBrew. I've got the formula
Oz used and the one I used. I'll go back to the peel then the treatment
again. I have a suspicion, based on pure intuition that a second round will
not be necessary. Somebody, somewhere, will find an off label use of a drug
(as was first done with Minoxidil) or food supplement that will bring back
hair within the next few years. Reliably.

I've worked in Science. I'm trained in Science and research. I have so very
little respect for its plodding along, as do many drug companies, who are
taking every mold, mineral, herb, spice, vegetable extract, eye of newt and
testing them all for medicinal properties. Penicillin was discovered by a
scientist who actually was curious about what caused his culture to go bad.
Take all the "discoveries" that are being made these days with respect to
food. Suddenly scientists are finding that food is good for you. That the
food and spices used in Indian and Oriental cooking aren't just there
because they balance Yin and Yang or the 3 doshas. It comes to pass that
Yin, Yang and the 3 doshas are merely ways of describing very powerful
medicinal effects. The food manufacturers are going wild. When I buy
Hershey's cocoa, there's a big pitch on the box about its anti-oxident
properties. Will tumeric be next? Will we find out that baldness is
actually caused by a type of bacteria, curable with an antibiotic? It
worked for ulcers. It's working for lots of cancers. I wouldn't be
surprised at all if all the pathways and mechanisms that have been
discovered about hair growth and loss is suddenly blown away by the
discovery that there's a yet unknown cause and simple cure.
Chuck
Posted: Mon Oct 23, 2006 4:20 pm
Guest
Well, I thought that the way retin-a worked was that it caused a mild
damage which in turn stimulated repair mechanisms in the skin. And that
is where the benefit comes from. But, unlike you, I do not have a
background in science so maybe I am way off the mark.

T wrote:
Quote:
"Chuck" <chuckfrasher@gmail.com> wrote in message
news:1161542191.059433.129550@h48g2000cwc.googlegroups.com...
z

I am surprised that you have achieved some long term results with the
OzBrew. Maybe that peeling and that damage stimulates a renewal of the
follicles or something.


Damage? What if the damage had already been done and the peel undid the
damage?
T
Posted: Mon Oct 23, 2006 8:35 pm
Guest
"Chuck" <chuckfrasher@gmail.com> wrote in message
news:1161631247.725349.15780@f16g2000cwb.googlegroups.com...
Quote:
Well, I thought that the way retin-a worked was that it caused a mild
damage which in turn stimulated repair mechanisms in the skin. And that
is where the benefit comes from. But, unlike you, I do not have a
background in science so maybe I am way off the mark.

Oz did not have a background in science. He was a marketing type. He

believed that The Peel removed something that had overgrown or filled up the
follicles. I suppose one could try TCA (available on eBay or from chemical
supply houses). Be very careful, as this'll peel most all your skin off if
left on too long or you use too high a concentration. You'll wind up white
as a ghost the way the people who do the deep peels do, as the layer which
produces the skin pigment is gone. See if merely removing layers of skin
does the trick. Me, I think there's something special about the MSM and
DMSO used in the peel.

As far as I remember, you're right. Retin-A does a peel. Eventually you
peel and you develop thicker and smoother skin. But hair is not skin.
 
Page 1 of 1       All times are GMT - 5 Hours
The time now is Fri Jan 09, 2009 2:15 am