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Science Forum Index » Life Extension Forum » Statin gels increase bone 300+%
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| kofi |
 Posted: Sat Jan 03, 2004 1:07 am |
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Br J Oral Maxillofac Surg. 2003 Aug;41(4):244-8. Related Articles, Links
Click here to read
Statin collagen grafts used to repair defects in the parietal bone
of rabbits.
Wong RW, Rabie AB.
Orthodontics, University of Hong Kong, Government of Hong Kong SAR,
Hong Kong.
We compared the amount of new bone produced by statin collagen
grafts with that produced by collagen grafts. Fifteen bone defects were
created in the parietal bone of nine New Zealand White rabbits. In the
experimental group, five defects were grafted with simvastatin dissolved
in water for injection mixed with absorbable collagen sponge. In the
control groups, five defects were grafted with water for injection mixed
with absorbable collagen sponge alone (active control) and five were
left empty (passive control). Animals were killed on day 14 and the
defects were prepared for histological assessment. Serial sections were
cut across the whole defect. Quantitative analysis of new bone formation
was made on 100 sections using image analysis. A total of 308% more new
bone was present in defects grafted with statin collagen grafts than
those grafted with collagen grafts alone (P<0.0001). No bone was formed
in the passive control group. In conclusion, statin collagen grafts were
osteoinductive and can be used as a material for bone grafts.
PMID: 12946667 [PubMed - indexed for MEDLINE] |
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