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Science Forum Index » Life Extension Forum » Location of Up-To-Date FAQ
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| Joel Kehle |
 Posted: Tue Dec 23, 2003 7:21 pm |
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The latest FAQ I was able to locate for sci.life-extension is the July
5, 1993 Edition. Does a more up-to-date edition exist?
If not, is their a good source of the latest information about
life-extension.
Thanks!
JK |
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| michaelprice |
| Posted: Fri Dec 26, 2003 7:53 am |
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Hi Joel,
there is no FAQ because there is no consensus.
Instead there is a spectrum of views ranging from
calorie restriction to drugs and dietary supplements
(vitamins etc) or even cryonics. These views are
not necessarily contradictory - although you could
be forgiven for thinking they are if you judged by
how fervently people fight their respective corners here!
These are exciting times for LE - decisions you
make now are likely to substatially affect your state
of health and longevity in the decades to come. Of course
this too is disputed - some people will argue that no (or little)
action need to be taken until your middle age or later, others
(including me) that the earlier the intervention the better.
My own emphasis is on enzymic cofactors, which
translates into megadoses of the B-vitamins and some
minerals.
See http://mcp.longevity-report.com for my views
with supporting evidence.
Cheers,
Michael C Price
----------------------------------------
http://mcp.longevity-report.com
http://www.hedweb.com/manworld.htm
"Joel Kehle" <joelr@kehle.com> wrote in message
news:cc5e0e0.0312231621.d9bc59f@posting.google.com...
Quote: The latest FAQ I was able to locate for sci.life-extension is the July
5, 1993 Edition. Does a more up-to-date edition exist?
If not, is their a good source of the latest information about
life-extension.
Thanks!
JK |
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| Back to top |
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| michaelprice |
| Posted: Thu Jan 01, 2004 8:24 am |
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Guest
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I said:
Quote: These are exciting times for LE - decisions you
make now are likely to substatially affect your state
of health and longevity in the decades to come. Of course
this too is disputed - some people will argue that no (or little)
action need to be taken until your middle age or later, others
(including me) that the earlier the intervention the better.
Follow-up. Note the phrase "if started early" in the title.
Life Extension Weekly Update Exclusive
Vitamin E supplementation helps prevent Alzheimer's plaques in young mice if
started early
An article published online on December 4 2003 in the journal of the
Federation of the American Societies for Experimental Biology (FASEB
http://www.fasebj.org/ ), detailed the findings of researchers from the
University of Pennsylvania that vitamin E supplemented early in life is
effective in reducing amyloid-beta levels and amyloid deposition in a mouse
model of Alzheimer's disease (AD). Amyloid-beta is a peptide that
accumulates as plaque in the brains of individuals with Alzheimer's disease.
The protective benefit of vitamin E supplementation was found when vitamin E
was started early in life.
Mice bred to develop amyloid-beta deposits received diets supplemented with
vitamin E or a placebo starting at five months of age until the age of
thirteen months. In a second experiment, the mice received the vitamin or a
placebo from the age of fourteen months until the age of twenty months.
At the conclusion of the experiments, brain lipid peroxidation was found to
be reduced in the mice receiving vitamin E compared to the placebo groups.
The mice receiving the vitamin from five to thirteen months experienced a
significant reduction in amyloid-beta levels and amyloid-beta deposition
compared to the placebo group who experienced amyloid-beta levels and
deposition consistent with their age. In the second experiment, older mice
receiving vitamin E did not did not differ in regard to amyloid-beta
compared to the control group.
Because vitamin E suppresses lipid peroxidation, and because oxidative
stress has been shown to be increased in Alzheimer's disease, vitamin E may
help to prevent the disease due to its antioxidant ability, however it
evidently needs to be started early, before amyloid plaques have been
deposited. The authors conclude that, "any therapeutic strategy aimed at
targeting oxidative stress should be initiated at the earliest possible
state of the disease, ideally in subjects at high risk for developing AD."
(Sung S, et al, "Early vitamin E supplementiton in young but not aged mice
reduces AB levels and amyloid deposition in a transgenic model of Alzheimer'
s disease," FASEB, December 4 2003.)
--
Cheers,
Michael C Price
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http://mcp.longevity-report.com
http://www.hedweb.com/manworld.htm |
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