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Science Forum Index » Life Extension Forum » Silymarin restores antioxidant function in diabetic pancreas
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| kofi |
 Posted: Wed Dec 31, 2003 7:33 am |
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Comp Biochem Physiol C Toxicol Pharmacol. 2003 Nov;136(3):205-12.
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Silymarin increases antioxidant enzymes in alloxan-induced diabetes
in rat pancreas.
Soto C, Recoba R, Barron H, Alvarez C, Favari L.
Departamento de Sistemas Biologicos, Universidad Autonoma
Metropolitana-Xochimilco. Calzada del Hueso 1100, Col. Villa Quietud, CP
04960, Mexico, DF, Mexico
The aim of this study was to analyze the effect of the flavonoid
silymarin, a free radical scavenger that prevents lipoperoxidation, on
the pancreatic activity of superoxide dismutase (SOD), glutathione
peroxidase (GSHPx) and catalase (CAT) in rats with alloxan-induced
diabetes mellitus. Alloxan intoxicated rats were treated with silymarin
in two manners, simultaneously (four or eight doses) or 20 days after
alloxan administration for 9 weeks. Alloxan elicited a transient
increase in the activity of the three enzymes, which decreased after 5
days of treatment. On its own, silymarin significantly increased the
activity of these enzymes. Simultaneous treatment with alloxan and
silymarin also induced an increment in the activity of the enzymes
followed by a delayed decrease (four doses). However, a longer treatment
with silymarin (eight doses) induced a more sustained effect.
Interestingly, silymarin treatment recovered to control values for the
activity of the three-antioxidant enzymes that were significantly
diminished after 20 days of alloxan administration. It is suggested that
the protective effect of silymarin on pancreatic damage induced by
alloxan may be due to an increase in the activity of antioxidant enzymes
that, in addition to the glutathione system, constitute the more
important defense mechanisms against damage by free radicals.
PMID: 14659454 [PubMed - in process] |
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