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| babaessa... |
 Posted: Wed Jun 17, 2009 10:45 pm |
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| ironjustice... |
| Posted: Thu Jun 18, 2009 7:28 pm |
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On Jun 18, 1:45 am, babaessa <babae... at (no spam) gmail.com> wrote:
Mesothelioma Cancer <<
Iron mobilization from crocidolite as enhancer of collagen content in
rat lung fibroblasts*1
Concetta Garai, Paola Calzoni, Marco Ferrali and Mario Comporti
Institute of General Pathology, University of Siena, I-53100, Siena,
Italy
Received 30 November 1996; accepted 9 December 1996. ; Available
online 11 March 1999.
Abstract
Asbestos exposure causes pulmonary fibrosis by mechanisms that remain
uncertain.
There is increasing evidence that iron from asbestos is responsible
for many of its effects.
In this paper, we investigated the effect of iron mobilized from
crocidolite asbestos on
collagen content in rat lung fibroblast cultures under serum-free
conditions.
Crocidolite (2, 4, 6 ìg/cm2 well) increased collagen content in a dose-
dependent manner
(+ 42 ± 8, + 92 ± 10, and + 129 ± 13% vs controls).
This effect was specific for collagen, since it did not alter total
protein content and was
inhibited by the iron chelator deferoxamine (DFO).
Preincubation of crocidolite with citrate (1 mM) for 48 hr resulted in
iron mobilization
(51 ìM) and increased collagen production (> 3-fold) in treated
cells.
These effects occurred without the intervention of serum factors.
The absence of cell damage, proliferation or lipid peroxidation leads
to the supposition
that iron from crocidolite per se may act as a profibrogenic agent.
Although the in vivo participation of other cells and factors cannot
be excluded, we
conclude that iron released from crocidolite plays a role in collagen
increase occurring
during asbestosis.
Author Keywords: asbestos; pulmonary fibrosis; collagen metabolism;
iron chelates
Abbreviations: DFO, deferoxamine; ROS, reactive oxygen species; NTA,
nitriloacetate; IH, idiopathic hemochromatosis; RLF, rat lung
fibroblasts; FBS, fetal bovine serum; DMEM, Dulbecco's modified
Eagle's medium; LDH, lactate dehydrogenase; NBD-C1, 7-chloro-4-
nitrobenzen-2-oxa-1,3-diazole; PCA, perchloric acid; TEARS,
thiobarbituric acid reactive substances; MDA, malondialdehyde
Article Outline
* References
Corresponding author: Dr. C. Gardi, Institute of General Pathology,
University of Siena, via Aldo Moro, 53100 , SIENA, , Italy, Tel.
577-227002, FAX: 577-227009.
---------------
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[quote:2a63831815]
http://bymesothelioma.info/mesothelioma/mesothelioma-cancer.html
This a sort of cancer which is caused by bearing to asbestos. It is
when virulent cells rise in the Mesothelioma, a protecting backing
which covers many of the body's inner organs. The many usual site for
this sort of cancer is the pleura, the outdoor backing of the lungs
and the inner chest wall. It can additionally rise in the backing of
the intestinal cavity, the heart as well as the pericardium which is a
weal which surrounds the heart.
read morehttp://bymesothelioma.info/mesothelioma/mesothelioma-cancer.html[/quote:2a63831815] |
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| Jeff... |
| Posted: Tue Jun 23, 2009 5:12 pm |
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babaessa wrote:
[quote:f397e81958]Mesothelioma Cancer
http://bymesothelioa.info/mesothelioma/mesothelioma-cancer.html
This a sort of cancer which is caused by bearing
[/quote:f397e81958]
What kind of bearings? Wheel bearings? Rod bearings?
[quote:f397e81958]to asbestos. It is
when virulent cells rise in the Mesothelioma,
[/quote:f397e81958]
Do the rise all the ways to the ceiling?
[quote:f397e81958]a protecting backing
which covers many of the body’s inner organs.
[/quote:f397e81958]
Is this like the backing on a chair?
[quote:f397e81958]The many usual site for
[/quote:f397e81958]
What is "many usual site?"
[quote:f397e81958]this sort of cancer is the pleura, the outdoor backing of the lungs
and the inner chest wall.
[/quote:f397e81958]
The outdoor backing? What happens indoors?
[quote:f397e81958]It can additionally rise in the backing of
the intestinal cavity, the heart as well as the pericardium which is a
weal which surrounds the heart.
[/quote:f397e81958]
A weal? What's that?
You need a better editor for your spam.
[quote:f397e81958]read more
http://bymesothlioma.info/mesothelioma/mesothelioma-cancer.html[/quote:f397e81958] |
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