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Science Forum Index » Life Extension Forum » Erythropoietin and oxidative stress....
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 Posted: Wed May 14, 2008 11:57 am |
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Erythropoietin is what Anthony Cerami has been researching since he
gave up trying to break crosslinks.
Curr Neurovasc Res. 2008 May;5(2):125-42.
Erythropoietin and oxidative stress.Maiese K, Chong ZZ, Hou J, Shang
YC.
Department of Neurology, 8C-1 UHC, Wayne State University School of
Medicine, 4201 St. Antoine, Detroit, MI 48201, USA. aa2088 at (no spam) wayne.edu.
Unmitigated oxidative stress can lead to diminished cellular
longevity, accelerated aging, and accumulated toxic effects for an
organism. Current investigations further suggest the significant
disadvantages that can occur with cellular oxidative stress that can
lead to clinical disability in a number of disorders, such as
myocardial infarction, dementia, stroke, and diabetes. New therapeutic
strategies are therefore sought that can be directed toward
ameliorating the toxic effects of oxidative stress. Here we discuss
the exciting potential of the growth factor and cytokine
erythropoietin for the treatment of diseases such as cardiac ischemia,
vascular injury, neurodegeneration, and diabetes through the
modulation of cellular oxidative stress. Erythropoietin controls a
variety of signal transduction pathways during oxidative stress that
can involve Janus-tyrosine kinase 2, protein kinase B, signal
transducer and activator of transcription pathways, Wnt proteins,
mammalian forkhead transcription factors, caspases, and nuclear factor
kappaB. Yet, the biological effects of erythropoietin may not always
be beneficial and may be poor tolerated in a number of clinical
scenarios, necessitating further basic and clinical investigations
that emphasize the elucidation of the signal transduction pathways
controlled by erythropoietin to direct both successful and safe
clinical care.
PMID: 18473829 [PubMed - in process] |
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