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Science Forum Index » Life Extension Forum » One for the stoners: Targeting the endocannabinoid...
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 Posted: Fri May 09, 2008 2:00 pm |
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Enhance dude enhance.
Nat Rev Drug Discov. 2008 May;7(5):438-55. Links
Targeting the endocannabinoid system: to enhance or reduce?Di Marzo V.
Endocannabinoid Research Group, Institute of Biomolecular Chemistry,
National Research Council (CNR), Via Campi Flegrei 34, 80078,
Pozzuoli, Naples, Italy. vdimarzo at (no spam) icmib.na.cnr.it
As our understanding of the endocannabinoids improves, so does the
awareness of their complexity. During pathological states, the levels
of these mediators in tissues change, and their effects vary from
those of protective endogenous compounds to those of dysregulated
signals. These observations led to the discovery of compounds that
either prolong the lifespan of endocannabinoids or tone down their
action for the potential future treatment of pain, affective and
neurodegenerative disorders, gastrointestinal inflammation, obesity
and metabolic dysfunctions, cardiovascular conditions and liver
diseases. When moving to the clinic, however, the pleiotropic nature
of endocannabinoid functions will require careful judgement in the
choice of patients and stage of the disorder for treatment.
PMID: 18446159 [PubMed - in process] |
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