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Science Forum Index » Medicine - Cancer Forum » histone deacetylase inhibitors are potent HIF-1 inhibitors
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| Steve |
 Posted: Mon Apr 28, 2008 6:28 pm |
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Guest
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HIF1-alpha is very important in the spread and metastastes of tumors in low
oxygen environment (which is most tumors).
http://www.ncbi.nlm.nih.gov/pubmed/17102633
Cell Cycle. 2006 Nov 1;5(21):2430-5. Epub 2006 Sep 13.Links
Effects of histone deacetylase inhibitors on HIF-1.
Liang D, Kong X, Sang N.
Cardeza Foundation, Department of Medicine and Kimmel Cancer Center, Thomas
Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Hypoxia inducible factors (HIF) are the master transcriptional regulators of
angiogenesis and energy metabolism in mammals. Histone deacetylase
inhibitors (HDAIs) are among the promising anti -cancer compounds currently
in clinical trials. In addition to inducing hyperacetylation of histones,
HDAIs have been found to repress HIF function, which has been construed as
an important pharmacological mechanism underlying the HDAI -mediated
repression of tumor growth and angiogenesis. While HDAIs are potent
inhibitors of HIF function and thus may be useful in the prevention and
treatment of cancers, a major dilemma is that they may induce
hyperacetylation of nonspecific targets thus causing side effects. A better
understanding is now required of the molecular and biochemical mechanisms
underlying the anti -HIF effects of these compounds. Here we summarize the
recent advances towards a better understanding of these molecular and
biochemical mechanisms. |
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