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Science Forum Index » Life Extension Forum » Piperine lowers thyroid hormones and glucose in blood of mal
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| kofi |
 Posted: Wed Dec 31, 2003 11:17 pm |
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Some people advocate taking piperine to enhance curcumin absorption.
I'm not real sure what this leaves you with if you can't take curcumin
with it. Topical absorption, maybe?
Horm Metab Res. 2003 Sep;35(9):523-6. Related Articles, Links
Click here to read
Piperine lowers the serum concentrations of thyroid hormones,
glucose and hepatic 5'D activity in adult male mice.
Panda S, Kar A.
School of Life Sciences, Devi Ahilya University, Indore, India.
Piperine, the main alkaloid of Piper nigrum fruits, was evaluated
for its thyroid hormone and glucose regulatory efficacy in adult male
Swiss albino mice. Its daily oral administration (2.50 mg/kg) for 15
days lowered the serum levels of both the thyroid hormones, thyroxin (T
(4)) and triiodothyronine (T (3)) as well as glucose concentrations with
a concomitant decrease in hepatic 5'D enzyme and glucose-6-phospatase
(G-6-Pase) activity. However, no significant alterations were observed
in animals treated with 0.25 mg/kg of piperine in any of the activities
studied except an inhibition in serum T (3) concentration. The decrease
in T (4), T (3) concentrations and in G-6-Pase were comparable to that
of a standard antithyroid drug, Proylthiouracil (PTU). The hepatic
lipid-peroxidation (LPO) and the activity of endogenous antioxidants,
superoxide dismutase (SOD), and catalase (CAT) were not significantly
altered in either of the doses. It appears that the action of P. nigrum
on thyroid functions is mediated through its active alkaloid, piperine.
We also suggest that a higher dose of piperine may inhibit thyroid
function and serum glucose concentration in euthyroid individuals.
PMID: 14517767 [PubMed - in process] |
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| Paul Wakfer |
| Posted: Fri Jan 02, 2004 1:07 am |
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kofi <kofi@anon.un> wrote in message news:<kofi-79A567.22181431122003@news04.west.earthlink.net>...
Quote: Some people advocate taking piperine to enhance curcumin absorption.
I'm not real sure what this leaves you with if you can't take curcumin
with it. Topical absorption, maybe?
You can always take larger doses without piperine as I do.
The 2.5 mg/kg for a mouse *is* near to what people taking piperine as
an absorption booster (for several supplements - usually 5 mg per
capsule) are getting daily. However, this result may not be so bad as
you think.
The study merely says that it lowers serum levels of both thyroid
hormones and glucose. These are also effects which strong CR causes.
In theory, they should both be longevity promoting. So as long as the
result does not also reduce brain function and body vitality it should
be beneficial.
This study may lead to me reversing my stand on piperine and I may
decide to use supplements containing it after all. I will have to
investigate the current picture more fully before I decide.
--Paul Wakfer
MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
The Self-Sovereign Individual Project - http://selfsip.org
Rational freedom by self-sovereignty & social contracting
Quote: Horm Metab Res. 2003 Sep;35(9):523-6. Related Articles, Links
Click here to read
Piperine lowers the serum concentrations of thyroid hormones,
glucose and hepatic 5'D activity in adult male mice.
Panda S, Kar A.
School of Life Sciences, Devi Ahilya University, Indore, India.
Piperine, the main alkaloid of Piper nigrum fruits, was evaluated
for its thyroid hormone and glucose regulatory efficacy in adult male
Swiss albino mice. Its daily oral administration (2.50 mg/kg) for 15
days lowered the serum levels of both the thyroid hormones, thyroxin (T
(4)) and triiodothyronine (T (3)) as well as glucose concentrations with
a concomitant decrease in hepatic 5'D enzyme and glucose-6-phospatase
(G-6-Pase) activity. However, no significant alterations were observed
in animals treated with 0.25 mg/kg of piperine in any of the activities
studied except an inhibition in serum T (3) concentration. The decrease
in T (4), T (3) concentrations and in G-6-Pase were comparable to that
of a standard antithyroid drug, Proylthiouracil (PTU). The hepatic
lipid-peroxidation (LPO) and the activity of endogenous antioxidants,
superoxide dismutase (SOD), and catalase (CAT) were not significantly
altered in either of the doses. It appears that the action of P. nigrum
on thyroid functions is mediated through its active alkaloid, piperine.
We also suggest that a higher dose of piperine may inhibit thyroid
function and serum glucose concentration in euthyroid individuals.
PMID: 14517767 [PubMed - in process] |
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| Tim Tyler |
| Posted: Fri Jan 02, 2004 4:46 am |
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Paul Wakfer <tom@morelife.org> wrote or quoted:
[curcumin]
Quote: You can always take larger doses without piperine as I do.
As a brief note, I never managed to consume very much turmeric in
powdered form - due to palatability issues.
However I have since discovered that I can buy the stuff fresh from
my local chinese supermarket - along with other members of the
Zingiberaceae (ginger) family - e.g. galangal - and finger-root.
Fresh turmeric is great stuff. To me it seems it is to the powder
about as fresh strawberries are to strawberry powder. To those who
haven't already done so - if you get the opportunity - check it out.
--
__________
|im |yler http://timtyler.org/ tim@tt1lock.org Remove lock to reply. |
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