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Science Forum Index » Life Extension Forum » Balding as a hyperinsuliinemic disease: low SHBG, IGFBP-3 in
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| kofi |
 Posted: Wed Dec 31, 2003 12:18 am |
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Guest
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One of the more assinine qualities of Pubmed is that you can miss papers
on "balding" if you just search for "androgenic alopecia." This one
would have slipped by me if I hadn't been looking at SHBG.
Comp Biochem Physiol A Mol Integr Physiol. 2003 Sep;136(1):95-112.
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Hyperinsulinemic diseases of civilization: more than just Syndrome X.
Cordain L, Eades MR, Eades MD.
Department of Health and Exercise Science, Colorado State
University, Fort Collins, CO 80523, USA.
Compensatory hyperinsulinemia stemming from peripheral insulin
resistance is a well-recognized metabolic disturbance that is at the
root cause of diseases and maladies of Syndrome X (hypertension, type 2
diabetes, dyslipidemia, coronary artery disease, obesity, abnormal
glucose tolerance). Abnormalities of fibrinolysis and hyperuricemia also
appear to be members of the cluster of illnesses comprising Syndrome X.
Insulin is a well-established growth-promoting hormone, and recent
evidence indicates that hyperinsulinemia causes a shift in a number of
endocrine pathways that may favor unregulated tissue growth leading to
additional illnesses. Specifically, hyperinsulinemia elevates serum
concentrations of free insulin-like growth factor-1 (IGF-1) and
androgens, while simultaneously reducing insulin-like growth
factor-binding protein 3 (IGFBP-3) and sex hormone-binding globulin
(SHBG). Since IGFBP-3 is a ligand for the nuclear retinoid X receptor
alpha, insulin-mediated reductions in IGFBP-3 may also influence
transcription of anti-proliferative genes normally activated by the
body's endogenous retinoids. These endocrine shifts alter cellular
proliferation and growth in a variety of tissues, the clinical course of
which may promote acne, early menarche, certain epithelial cell
carcinomas, increased stature, myopia, cutaneous papillomas (skin tags),
acanthosis nigricans, polycystic ovary syndrome (PCOS) and male vertex
balding. Consequently, these illnesses and conditions may, in part, have
hyperinsulinemia at their root cause and therefore should be classified
among the diseases of Syndrome X.
PMID: 14527633 [PubMed - in process] |
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