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J Immunol. 2009 Aug 15;183(4):2435-43. Epub 2009 Jul 22.
IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T
cells.
Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, Weiner HL.
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard
Medical School, Boston, MA 02115, USA.
Although the physiologic pathways that control regulatory T cells
(Foxp3-expressing regulatory T cells, IL-10-secreting Tr1 cells) and
Th17 cells in rodents have been defined, the factors that control these
differentiation pathways in humans are not well understood. In this
study, we show that IL-27 promotes the differentiation of
IL-10-secreting Tr1 cells while inhibiting Th17 generation and molecules
associated with Th17 function. Furthermore, IL-27 inhibits
IL-17-polarizing cytokines on dendritic cells, which in turn decrease
IL-17 secretion from T cells. Our results demonstrate that IL-27 plays a
key role in human T cells by promoting IL-10-secreting Tr1 cells and
inhibiting Th17 cells and thus provides a dual regulatory mechanism to
control autoimmunity and tissue inflammation.
Publication Types:
* Research Support, N.I.H., Extramural
PMID: 19625647 |
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