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| Kofi... |
 Posted: Fri Nov 06, 2009 6:24 am |
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Guest
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Given the role of angiotensin in chronic fatigue [PMID 18684570], this
may be a specifically male adaptation to counter fatigue from physical
exertion. If so, then aldosterone may be involved too.
J Hypertens. 2009 Oct 3
Regulation of multiple renin-angiotensin system genes by Sry.
Milsted A, Underwood AC, Dunmire J, Delpuerto HL, Martins AS, Ely DL,
Turner ME.
aDepartment of Biology and Program in Integrated Bioscience, University
of Akron, Akron, USA bDivision of Mathematics and Sciences, Walsh
University, North Canton, Ohio, USA cGeneral Pathology Department,
Federal University of Minas Gerais, Brazil dDepartment of Physiology and
Biophysics, UFMG 31270-010 Belo Horizonte, Minas Gerais, Brazil.
BACKGROUND AND OBJECTIVE: We demonstrated that the Sry gene complex on
the spontaneously hypertensive rat (SHR) Y chromosome is a candidate
locus for hypertension that accounts for the SHR Y chromosome blood
pressure effect. All rat strains examined to date share six Sry loci,
and a seventh Sry locus (Sry3) appears to be unique to SHR male rats.
Previously, we showed that Sry1 increased activity of the tyrosine
hydroxylase promoter in transfected PC12 cells, and Sry1 delivered to
adrenal gland of Wistar-Kyoto (WKY) rats increased blood pressure and
sympathetic nervous system activity. The objective of this study was to
determine whether renin-angiotensin system genes participate in
Sry-mediated effects. METHOD: Sry expression vectors were co-transfected
into CHO cells with luciferase reporter constructs containing promoters
of angiotensinogen (Agt -1430/+22), renin (Ren -1050/-1),
angiotensin-converting enzyme (ACE) (ACE -1677/+21) and ACE2 (ACE2
-1091/+83). RESULTS: Sry1, Sry2 and Sry3 differentially upregulated
activity of the promoters of angiotensinogen, renin and ACE genes and
downregulated ACE2 promoter activity. The largest effect was seen with
Sry3, which increased activity of angiotensinogen promoter by 1.7-fold,
renin promoter by 1.3-fold, ACE promoter by 2.6-fold and decreased
activity of ACE2 promoter by 0.5-fold. The effect of Sry1 on promoter
activity was significantly less than that of Sry3. Sry2 activated
promoters at a significantly lower level than Sry1 did. The result of
either an additive effect of Sry regulation of multiple genes in the
renin-angiotensin system or alterations in expression of a single gene
could favor increased levels of Ang II and decreased levels of
Ang-(1-7). CONCLUSION: These actions of Sry could result in increased
blood pressure in males and contribute to sex differences in blood
pressure.
PMID: 19809364 |
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| Nomen Nescio... |
| Posted: Fri Nov 06, 2009 8:12 am |
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On Nov 6, 4:24 am, Kofi <k... at (no spam) anon.un> wrote:
[quote]Given the role of angiotensin in chronic fatigue [PMID 18684570], this
may be a specifically male adaptation to counter fatigue from physical
exertion. If so, then aldosterone may be involved too.
J Hypertens. 2009 Oct 3
Regulation of multiple renin-angiotensin system genes by Sry.
Milsted A, Underwood AC, Dunmire J, Delpuerto HL, Martins AS, Ely DL,
Turner ME.
aDepartment of Biology and Program in Integrated Bioscience, University
of Akron, Akron, USA bDivision of Mathematics and Sciences, Walsh
University, North Canton, Ohio, USA cGeneral Pathology Department,
Federal University of Minas Gerais, Brazil dDepartment of Physiology and
Biophysics, UFMG 31270-010 Belo Horizonte, Minas Gerais, Brazil.
BACKGROUND AND OBJECTIVE: We demonstrated that the Sry gene complex on
the spontaneously hypertensive rat (SHR) Y chromosome is a candidate
locus for hypertension that accounts for the SHR Y chromosome blood
pressure effect. All rat strains examined to date share six Sry loci,
and a seventh Sry locus (Sry3) appears to be unique to SHR male rats.
Previously, we showed that Sry1 increased activity of the tyrosine
hydroxylase promoter in transfected PC12 cells, and Sry1 delivered to
adrenal gland of Wistar-Kyoto (WKY) rats increased blood pressure and
sympathetic nervous system activity. The objective of this study was to
determine whether renin-angiotensin system genes participate in
Sry-mediated effects. METHOD: Sry expression vectors were co-transfected
into CHO cells with luciferase reporter constructs containing promoters
of angiotensinogen (Agt -1430/+22), renin (Ren -1050/-1),
angiotensin-converting enzyme (ACE) (ACE -1677/+21) and ACE2 (ACE2
-1091/+83). RESULTS: Sry1, Sry2 and Sry3 differentially upregulated
activity of the promoters of angiotensinogen, renin and ACE genes and
downregulated ACE2 promoter activity. The largest effect was seen with
Sry3, which increased activity of angiotensinogen promoter by 1.7-fold,
renin promoter by 1.3-fold, ACE promoter by 2.6-fold and decreased
activity of ACE2 promoter by 0.5-fold. The effect of Sry1 on promoter
activity was significantly less than that of Sry3. Sry2 activated
promoters at a significantly lower level than Sry1 did. The result of
either an additive effect of Sry regulation of multiple genes in the
renin-angiotensin system or alterations in expression of a single gene
could favor increased levels of Ang II and decreased levels of
Ang-(1-7). CONCLUSION: These actions of Sry could result in increased
blood pressure in males and contribute to sex differences in blood
pressure.
PMID: 19809364
[/quote]
Ernie does not have a Y chromosome. |
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| Ernie... |
| Posted: Fri Nov 06, 2009 10:37 am |
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Guest
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On Nov 6, 1:12 pm, Nomen Nescio <nomennes... at (no spam) mail.com> wrote:
[quote]On Nov 6, 4:24 am, Kofi <k... at (no spam) anon.un> wrote:
Given the role of angiotensin in chronic fatigue [PMID 18684570], this
may be a specifically male adaptation to counter fatigue from physical
exertion. If so, then aldosterone may be involved too.
J Hypertens. 2009 Oct 3
Regulation of multiple renin-angiotensin system genes by Sry.
Milsted A, Underwood AC, Dunmire J, Delpuerto HL, Martins AS, Ely DL,
Turner ME.
aDepartment of Biology and Program in Integrated Bioscience, University
of Akron, Akron, USA bDivision of Mathematics and Sciences, Walsh
University, North Canton, Ohio, USA cGeneral Pathology Department,
Federal University of Minas Gerais, Brazil dDepartment of Physiology and
Biophysics, UFMG 31270-010 Belo Horizonte, Minas Gerais, Brazil.
BACKGROUND AND OBJECTIVE: We demonstrated that the Sry gene complex on
the spontaneously hypertensive rat (SHR) Y chromosome is a candidate
locus for hypertension that accounts for the SHR Y chromosome blood
pressure effect. All rat strains examined to date share six Sry loci,
and a seventh Sry locus (Sry3) appears to be unique to SHR male rats.
Previously, we showed that Sry1 increased activity of the tyrosine
hydroxylase promoter in transfected PC12 cells, and Sry1 delivered to
adrenal gland of Wistar-Kyoto (WKY) rats increased blood pressure and
sympathetic nervous system activity. The objective of this study was to
determine whether renin-angiotensin system genes participate in
Sry-mediated effects. METHOD: Sry expression vectors were co-transfected
into CHO cells with luciferase reporter constructs containing promoters
of angiotensinogen (Agt -1430/+22), renin (Ren -1050/-1),
angiotensin-converting enzyme (ACE) (ACE -1677/+21) and ACE2 (ACE2
-1091/+83). RESULTS: Sry1, Sry2 and Sry3 differentially upregulated
activity of the promoters of angiotensinogen, renin and ACE genes and
downregulated ACE2 promoter activity. The largest effect was seen with
Sry3, which increased activity of angiotensinogen promoter by 1.7-fold,
renin promoter by 1.3-fold, ACE promoter by 2.6-fold and decreased
activity of ACE2 promoter by 0.5-fold. The effect of Sry1 on promoter
activity was significantly less than that of Sry3. Sry2 activated
promoters at a significantly lower level than Sry1 did. The result of
either an additive effect of Sry regulation of multiple genes in the
renin-angiotensin system or alterations in expression of a single gene
could favor increased levels of Ang II and decreased levels of
Ang-(1-7). CONCLUSION: These actions of Sry could result in increased
blood pressure in males and contribute to sex differences in blood
pressure.
PMID: 19809364
Ernie does not have a Y chromosome.- Hide quoted text -
- Show quoted text -
[/quote]
asshole farrel does not have a brain. Ernie |
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