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| Olafur Pall Olafsson... |
 Posted: Wed Oct 28, 2009 7:47 pm |
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Br J Nutr. 2009 Jun 1:1-7. [Epub ahead of print]
Soya isoflavone supplementation enhances spatial working memory in
men.
Thorp AA, Sinn N, Buckley JD, Coates AM, Howe PR.
Nutritional Physiology Research Centre and ATN Centre for Metabolic
Fitness, Sansom Institute for Health Research, University of South
Australia, Adelaide, SA, Australia.
Females perform better in certain memory-related tasks than males. Sex
differences in cognitive performance may be attributable to
differences in circulating oestrogen acting on oestrogen beta
receptors (ERbeta) which are prevalent in brain regions such as the
hippocampus, frontal lobe and cortex that mediate cognitive functions.
Since soya isoflavones are known to activate ERbeta, chronic
isoflavone supplementation in males may improve cognitive performance
in memory-related tasks. A 12-week double-blind, placebo-controlled
cross-over trial was conducted in thirty-four healthy men to
investigate the effect of isoflavone supplementation on cognitive
function. Volunteers were randomised to take four capsules/d
containing soya isoflavones (116 mg isoflavone equivalents/d: 68 mg
daidzein, 12 mg genistein, 36 mg glycitin) or placebo for 6 weeks, and
the alternate treatment during the following 6 weeks. Assessments of
memory (verbal episodic, auditory and working), executive function
(planning, attention, mental flexibility) and visual-spatial
processing were performed at baseline and after each treatment period.
Isoflavone supplementation significantly improved spatial working
memory (P = 0.01), a test in which females consistently perform better
than males. Compared with placebo supplementation, there were 18 %
fewer attempts (P = 0.01), 23 % fewer errors (P = 0.02) and 17 % less
time (P = 0.03) required to correctly identify the requisite
information. Isoflavones did not affect auditory and episodic memory
(Paired Associate Learning, Rey's Auditory Verbal Learning Task,
Backward Digit Span and Letter-Number Sequencing), executive function
(Trail Making and Initial Letter Fluency Task) or visual-spatial
processing (Mental Rotation Task). Isoflavone supplementation in
healthy males may enhance cognitive processes which appear dependent
on oestrogen activation.
PMID: 19480732 [PubMed - as supplied by publisher]
# Eating soya improves human memory.
Psychopharmacology (Berl). 2001 Oct; 157(4):430-6.
[Psychopharmacology (Berl). 2001]
# The effects of dietary supplementation with isoflavones from red
clover on cognitive function in postmenopausal women.
Climacteric. 2004 Mar; 7(1):70-7.
[Climacteric. 2004]
# The effects of soy milk and isoflavone supplements on cognitive
performance in healthy, postmenopausal women.
J Nutr Health Aging. 2007 Mar-Apr; 11(2):155-64.
[J Nutr Health Aging. 2007]
# Review[Cognition, schizophrenia and the effect of antipsychotics]
Encephale. 2006 May-Jun; 32(3 Pt 1):341-50.
[Encephale. 2006]
# ReviewCognitive and psychomotor effects of risperidone in
schizophrenia and schizoaffective disorder.
Clin Ther. 2008 Sep; 30(9):1565-89. |
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