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| Dave Saum... |
 Posted: Wed Oct 28, 2009 9:50 am |
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http://www.sciencedaily.com/releases/2009/10/091026161850.htm
Weekly And Biweekly Vitamin D2 Prevents Vitamin D Deficiency
ScienceDaily (Oct. 28, 2009) — Boston University School of Medicine
researchers (BUSM) have found that 50,000 International Units (IU) of
vitamin D2, given weekly for eight weeks, effectively treats vitamin D
deficiency. Vitamin D2 is a mainstay for the prevention and treatment of
vitamin D deficiency in children and adults. Continued treatment with the
same dose of vitamin D2 every other week for up to six years after the
initial eight-week period prevents vitamin D deficiency from recurring with
no toxicity.
The BUSM study appears online in the journal Archives of Internal Medicine.
Vitamin D is essential for strong bones because it helps the body absorb
calcium and phosphorus from the food we eat. Vitamin D deficiency can lead
to rickets in children and the painful bone disease osteomalacia in adults.
Vitamin D deficiency can also cause osteoporosis and has been linked to
increased risk of cancer, heart disease, diabetes, autoimmune diseases and
infectious diseases including influenza, according to senior author Michael
F. Holick, PhD, MD, director of the Bone Healthcare Clinic and the Vitamin
D, Skin and Bone Research Laboratory at Boston University School of
Medicine.
Of the 86 patients researchers studied, 41 patients who were vitamin D
deficient received eight weeks of 50,000 IU of vitamin D2 weekly prior to
starting maintenance therapy. For those patients, the mean pre-treatment
25-hydroxyvitamin D status (25(OH)D) level was 19 ng/ml, which increased to
37 ng/ml after eight weeks of weekly therapy. These patients were then
treated with 50,000 IU of vitamin D2 every other week and had a mean final
25(OH)D level of 47 ng/ml.
For the 45 patients who received only maintenance therapy of 50,000 IU of
vitamin D2 every two weeks, the mean pre-treatment 25(OH)D level was 27
ng/ml and the mean final level was 47 ng/ml.
"Vitamin D2 is effective in raising 25(OH)D levels when given in physiologic
and pharmacologic doses and is a simple method to treat and prevent vitamin
D deficiency," said Holick, who is also director of the General Clinical
Research Unit and professor of medicine, physiology and biophysics at BUSM.
"While treating and preventing vitamin D deficiency, these large doses of
vitamin D2 do not lead to vitamin D toxicity."
According to Holick, this is the first study demonstrating the efficacy of a
prescription therapy to prevent vitamin D deficiency longterm in routine
clinical practice.
Quest Diagnostics, the nation's leading provider of diagnostics testing,
information and services, analyzed the specimens used in the study.
--------------------------------------------------------------------------------
Adapted from materials provided by Boston University Medical Center, via
EurekAlert!, a service of AAAS. |
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| Pramesh Rutaji... |
| Posted: Wed Oct 28, 2009 10:24 am |
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Guest
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Why would anyone give a shit about vitamin D2? It's like claiming that
drinking 64 oz of soda every day prevents dehydration without
considering any of the downsides of the extra sugar (the body doesn't
make D2)! D blood levels are cleared from the body much faster if D2
was the driver than if D3 was supplemented. The report I've added shows
that D3 was 9 times more effective than D2, a very different result than
truth Holick is trying to hide.
http://www.nutraingredients-usa.com/Research/Vitamin-D3-more-potent-than-D2-further-evidence
Vitamin D3 more potent than D2, further evidence
21-Jun-2004
Related topics: Research, Vitamins & premixes
Vitamin D3 has significantly greater potency than another form of the
vitamin, D2, shows a small study, presented last week.
The researchers say D3 supplements will be much more effective at
preventing deficiency of the vitamin, a condition gaining increasing
attention from the medical community.
Researchers writing in The Lancet last year warned that pregnant women
and children should take vitamin D supplements to prevent a resurgence
of rickets, the failure to mineralise new bone tissue leading to poorly
formed bones. Its incidence is thought to be increasing due to several
current lifestyle factors, including greater use of sun protection creams.
Sunlight is the best source of vitamin D but for those exposed to little
sunlight, supplements are recommended. Even vitamin D-fortified foods,
such as cereals or yellow spreads, do not offer the recommended daily
allowance, according to recent surveys.
Since the 1930s, researchers have believed that vitamin D2 and D3 have
essentially the same benefits in people. However, recent studies have
suggested that vitamins D2 and D3 are not the same and D3 tends to be
more widely used. New findings, presented by Dr Laura Armas from
Creighton University in Omaha and colleagues at ENDO 2004 in New
Orleans, US, last week, appear to confirm this difference.
The researchers examined the potency of both forms by randomly giving a
single 50,000 IU dose of either vitamin D2 or D3 to 20 healthy male
volunteers. Over a period of 28 days, blood levels of vitamin D and its
product 25-hydroxyvitamin D were measured.
The two calciferols produced similar rises in serum concentration of the
native vitamin, indicating equivalent absorption. But while both
produced similar initial rises in serum 25 hydroxyvitamin D over the
first three days, serum 25OHD fell rapidly in the D2 treated subjects
and was not different from baseline at 14 days.
Meanwhile 25OHD continued to rise in the D3 treated subjects, peaking by
14 days and continuing to remain high.
Calculating the difference in potency by measuring the area under the
curve revealed an even greater difference with D3 more than nine times
more effective than D2.
The fall in 25OHD2 may reflect differences in the affinity of the
vitamin D binding protein for the two calciferols, said the researchers.
"Clearly vitamin D3 is the preferable form of vitamin D," they
concluded, adding that "physicians using vitamin D2 should be aware of
its markedly reduced potency and shorter duration of action".
The D3 form does however pose some limitations. Some manufacturers are
reluctant to use it as lanolin is used in its manufacture and this
presents issues
Dave Saum wrote:
[quote]http://www.sciencedaily.com/releases/2009/10/091026161850.htm
Weekly And Biweekly Vitamin D2 Prevents Vitamin D Deficiency
ScienceDaily (Oct. 28, 2009) — Boston University School of Medicine
researchers (BUSM) have found that 50,000 International Units (IU) of
vitamin D2, given weekly for eight weeks, effectively treats vitamin D
deficiency. Vitamin D2 is a mainstay for the prevention and treatment of
vitamin D deficiency in children and adults. Continued treatment with the
same dose of vitamin D2 every other week for up to six years after the
initial eight-week period prevents vitamin D deficiency from recurring with
no toxicity.
The BUSM study appears online in the journal Archives of Internal Medicine.
Vitamin D is essential for strong bones because it helps the body absorb
calcium and phosphorus from the food we eat. Vitamin D deficiency can lead
to rickets in children and the painful bone disease osteomalacia in adults.
Vitamin D deficiency can also cause osteoporosis and has been linked to
increased risk of cancer, heart disease, diabetes, autoimmune diseases and
infectious diseases including influenza, according to senior author Michael
F. Holick, PhD, MD, director of the Bone Healthcare Clinic and the Vitamin
D, Skin and Bone Research Laboratory at Boston University School of
Medicine.
Of the 86 patients researchers studied, 41 patients who were vitamin D
deficient received eight weeks of 50,000 IU of vitamin D2 weekly prior to
starting maintenance therapy. For those patients, the mean pre-treatment
25-hydroxyvitamin D status (25(OH)D) level was 19 ng/ml, which increased to
37 ng/ml after eight weeks of weekly therapy. These patients were then
treated with 50,000 IU of vitamin D2 every other week and had a mean final
25(OH)D level of 47 ng/ml.
For the 45 patients who received only maintenance therapy of 50,000 IU of
vitamin D2 every two weeks, the mean pre-treatment 25(OH)D level was 27
ng/ml and the mean final level was 47 ng/ml.
"Vitamin D2 is effective in raising 25(OH)D levels when given in physiologic
and pharmacologic doses and is a simple method to treat and prevent vitamin
D deficiency," said Holick, who is also director of the General Clinical
Research Unit and professor of medicine, physiology and biophysics at BUSM.
"While treating and preventing vitamin D deficiency, these large doses of
vitamin D2 do not lead to vitamin D toxicity."
According to Holick, this is the first study demonstrating the efficacy of a
prescription therapy to prevent vitamin D deficiency longterm in routine
clinical practice.
Quest Diagnostics, the nation's leading provider of diagnostics testing,
information and services, analyzed the specimens used in the study.
--------------------------------------------------------------------------------
Adapted from materials provided by Boston University Medical Center, via
EurekAlert!, a service of AAAS.
[/quote]
--
Pramesh Rutaji
p297tongue6221 at (no spam) newsguy.com - remove tongue to reply |
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