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| Kofi... |
 Posted: Tue Oct 27, 2009 8:16 am |
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J Neurochem. 2009 Aug;110(4):1226-40. Epub 2009 Jun 15.
The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the
ischemic brain.
Kim HJ, Leeds P, Chuang DM.
Molecular Neurobiology Section, Mood and Anxiety Disorders Program,
National Institute of Mental Health, Bethesda, MD 20892-1363, USA.
In the healthy adult brain, neurogenesis normally occurs in the
subventricular zone (SVZ) and hippocampal dentate gyrus (DG). Cerebral
ischemia enhances neurogenesis in neurogenic and non-neurogenic regions
of the ischemic brain of adult rodents. This study demonstrated that
post-insult treatment with a histone deacetylase inhibitor, sodium
butyrate (SB), stimulated the incorporation of bromo-2'-deoxyuridine
(BrdU) in the SVZ, DG, striatum, and frontal cortex in the ischemic
brain of rats subjected to permanent cerebral ischemia. SB treatment
also increased the number of cells expressing polysialic acid-neural
cell adhesion molecule, nestin, glial fibrillary acidic protein,
phospho-cAMP response element-binding protein (CREB), and brain-derived
neurotrophic factor (BDNF) in various brain regions after cerebral
ischemia. Furthermore, extensive co-localization of BrdU and polysialic
acid-neural cell adhesion molecule was observed in multiple regions
after ischemia, and SB treatment up-regulated protein levels of BDNF,
phospho-CREB, and glial fibrillary acidic protein. Intraventricular
injection of K252a, a tyrosine kinase B receptor antagonist, markedly
reduced SB-induced cell proliferation detected by BrdU and Ki67 in the
ipsilateral SVZ, DG, and other brain regions, blocked SB-induced nestin
expression and CREB activation, and attenuated the long-lasting
behavioral benefits of SB. Together, these results suggest that histone
deacetylase inhibitor-induced cell proliferation, migration and
differentiation require BDNF-tyrosine kinase B signaling and may
contribute to long-term beneficial effects of SB after ischemic injury.
Publication Types:
* Research Support, N.I.H., Intramural
PMID: 19549282 |
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| RArmant... |
| Posted: Tue Oct 27, 2009 4:03 pm |
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I wonder if beta-hydroxy butyrate would have the same effect?
Consuming MCT oil would be the way to generate beta-hydroxy butyrate.
On Tue, 27 Oct 2009 08:16:02 -0600, Kofi <kofi at (no spam) anon.un> wrote:
[quote]J Neurochem. 2009 Aug;110(4):1226-40. Epub 2009 Jun 15.
The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the
ischemic brain.
PMID: 19549282[/quote] |
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| Kofi... |
| Posted: Wed Oct 28, 2009 4:25 pm |
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In article <89ree5hvtkqrvq91sg32baiunmrv1illlf at (no spam) 4ax.com>, RArmant
<rarmant at (no spam) sbcglobal.net> wrote:
[quote]I wonder if beta-hydroxy butyrate would have the same effect?
Consuming MCT oil would be the way to generate beta-hydroxy butyrate.
[/quote]
It might account for the benefits of a ketogenic diet on certain
neurological problems. |
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| Doug Freyburger... |
| Posted: Fri Oct 30, 2009 8:50 am |
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Kofi wrote:
[quote]RArmant <rarmant at (no spam) sbcglobal.net> wrote:
I wonder if beta-hydroxy butyrate would have the same effect?
Consuming MCT oil would be the way to generate beta-hydroxy butyrate.
It might account for the benefits of a ketogenic diet on certain
neurological problems.
[/quote]
Given the effect of ketosis on seizure disorders I've long wondered at
the objection to low carbing by medical folks.
I get that there are religious or political reasons to push for
vegitarian eating and folks who want that dislike the meat eaten of low
carb systems (ignoring support for vegitarian low carbing). That folks
who hold such stances tend to do so for pacifist related reasons makes
the craziness of some anti-low-carbers interesting.
I get that the bad press towards saturated fat, which does not apply to
low carbers, tends to trigger crazy reactions by folks who want life to
be simple and doctors to be correct.
But ketosis is the result of a successful predator diet more than it's
the result of starvation. It doesn't make sense to me that doctors
would object.
It's interesting to me that someone subject to seizures would stop
having them by eating a successful predator diet and start having them
by eating a successful farmer diet. The high fat of typical low carbs
supplying extra essential fatty acids of better nerve cell function? |
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| Arbor B... |
| Posted: Sat Oct 31, 2009 10:39 am |
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It has nothing to do any of the reasons that you mentioned and all to
do with the fact that medical protocols in general are not adopted so
long that there aren't sufficient human study data.
At present, the Ketogenic Diet is not widely practiced even in
children epilepsy for which it was originally discovered, because of
many new drugs, it's difficult to maintain, the lack of explanation of
how it works, and in adults it raises cholesterol.
This is in Epilepsy for which it has been known for over 80 years and
sadly for other conditions where research began only very recently.
Arbor
[quote]Given the effect of ketosis on seizure disorders I've long wondered at
the objection to low carbing by medical folks.
I get that there are religious or political reasons to push for
vegitarian eating and folks who want that dislike the meat eaten of low
carb systems (ignoring support for vegitarian low carbing). That folks
who hold such stances tend to do so for pacifist related reasons makes
[/quote]
[quote]the craziness of some anti-low-carbers interesting.
I get that the bad press towards saturated fat, which does not apply to
low carbers, tends to trigger crazy reactions by folks who want life to
be simple and doctors to be correct.
But ketosis is the result of a successful predator diet more than it's
the result of starvation. It doesn't make sense to me that doctors
would object.
It's interesting to me that someone subject to seizures would stop
having them by eating a successful predator diet and start having them
by eating a successful farmer diet. The high fat of typical low carbs
supplying extra essential fatty acids of better nerve cell function?[/quote] |
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