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Oxaloacetate supplementation increases lifespan in C. elegans through
an AMPK/FOXO-dependent pathway.Williams DS, Cash A, Hamadani L, Diemer
T.
Departments of Pharmacology and Neurosciences, UCSD School of
Medicine, La Jolla, CA 92130.
SUMMARY Reduced dietary intake increases lifespan in a wide variety of
organisms. It also retards disease progression. We tested whether
dietary supplementation of citric acid cycle metabolites could mimic
this lifespan effect. We report that oxaloacetate supplementation
increased lifespan in C. elegans. The increase was dependent on the
transcription factor, FOXO/DAF-16, and the energy sensor, AMP-
activated protein kinase (AMPK), indicating involvement of a pathway
that is also required for lifespan extension through dietary
restriction. These results demonstrate that supplementation of the
citric acid cycle metabolite, oxaloacetate, influences a longevity
pathway, and suggest a tractable means of introducing the health-
related benefits of dietary restriction.
PMID: 19793063 |
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