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| Science Forum Index » Medicine - Nutrition Forum » VitB15 - Pangamic acid... |
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| Taka... |
 Posted: Thu Oct 15, 2009 5:30 am |
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Guest
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Vitamin B15 -- Pangamic Acid
This is still a fairly controversial "vitamin." The quotation marks
suggest that we are not sure whether it is a vitamin. It has not yet
been shown to be essential in the diet (vitamins must be supplied from
external sources), and no symptoms or deficiency diseases are clearly
revealed when consumption is restricted. The FDA has been concerned
about the wide range of medical conditions treated with it, primarily
in other countries, and therefore pangamic acid is not readily
available to the U.S. consumer. Because most of the information about
pangamic acid is dated and is mainly from European and former Soviet
Union research, I discuss this substance here mainly for
completeness.
The former Soviet Union had been the most enthusiastic about pangamic
acid, feeling that it is a very important nutrient with physiological
actions that can treat a multitude of symptoms and diseases. Soviet
scientists had shown that pangamic acid supplementation can reduce the
buildup of lactic acid in athletes and thereby lessen muscle fatigue
and increase endurance. It had been used regularly and commonly in the
Soviet Union for many problems, including alcoholism and drug
addiction; mental problems such as those of aging and senility,
minimal brain damage in children, autism, and schizophrenia; heart
disease and high blood pressure; diabetes; skin diseases; liver
disease; and chemical poisonings.
As I said, the FDA has taken pangamic acid products off the market.
Dimethyl glycine (DMG) has been used by some people as a substitute as
it is thought to increase pangamic acid production in the body.
Dimethyl glycine combines with gluconic acid to form pangamic acid. It
is thought that the DMG is the active component of pangamic acid.
Sources: Pangamic acid was first isolated in 1951 by Drs. Ernest
Krebs, Sr. and Jr., from apricot kernels, along with laetrile, termed
vitamin B17. At that time, as today, they were not sure whether it was
essential to life.
Pangamic acid is also found in whole grains such as brown rice,
brewer’s yeast, pumpkin and sunflower seeds, and beef blood. Water and
direct sunlight may reduce the potency and availability of B15 in
these foods.
Functions: Pangamic acid is mainly a methyl donor, which helps in the
formation of certain amino acids such as methionine. It may play a
role in the oxidation of glucose and in cell respiration. By this
function, it may reduce hypoxia (deficient oxygen) in cardiac and
other muscles. Like vitamin E, it acts as an antioxidant, helping to
lengthen cell life through its protection from oxidation. Pangamic
acid is also thought to offer mild stimulation to the endocrine and
nervous systems, and by enhancing liver function, it may help in the
detoxification process.
Uses: Although many of these uses are not proven, there have been
reports of pangamic acid or DMG providing some benefits for a wide
range of symptoms, diseases, and metabolic problems. It may be useful
for such symptoms as headaches, angina and musculoskeletal chest pain,
shortness of breath, insomnia, and general stress—to be used, of
course, only after specific medical conditions are ruled out.
B15 has been shown to lower blood cholesterol, so it could provide
some nutritional support for those with high serum cholesterol or
cardiovascular problems or to reduce heart and blood vessel disease
risks. It may also help improve circulation and general oxygenation of
cells and tissues, so it may be used with any decreased cardiac or
brain functions. Pangamic acid may be helpful in general for
atherosclerosis and hypertension, America’s most common diseases.
In Europe vitamin B15 has been used to treat premature aging, because
of both its circulatory stimulus and its antioxidant effect. It is
felt to be a helpful protectant from pollutants, especially carbon
monoxide. Pangamic acid (and possibly DMG) support for anyone living
in a large polluted city or with a high-stress lifestyle could be a
wave of the future.
In Russia, a big use of pangamic acid has been for treating those with
alcohol problems, possibly reducing the craving. It has been reported
to diminish hangover symptoms when alcohol has been abused. B15 has
also been used to treat fatigue, as well as asthma and rheumatism, and
it may even have some antiallergic properties. Some child
psychiatrists have reported good results using pangamic acid in
disturbed children; it may help by stimulating speaking ability and
other mental functions. B15 may also be useful in problems of autism.
More studies regarding all claims of the benefits of pangamic acid
must be done, of course, to see which ones may be valid. But as of
now, it certainly is a "vitamin" or supplemental nutrient with
potential health benefits and research interest.
Deficiency and toxicity: There are no known toxic effects from even
high amounts of pangamic acid; 50–100 mg. (and even more) taken three
times daily have revealed no side effects. There are reports of
initial mild nausea with use of pangamates at high levels, but this
only lasts a few days.
There is limited information about deficiencies of pangamic acid.
There are no clear problems when it is absent in the diet, though some
diminished circulatory and oxygenation functions are possible.
Decreased cell respiration—that is, decreased oxygen use by cells—may
influence many other cellular functions which may lead to effects on
the heart.
Requirements: There is no RDA for pangamic acid. At the time of this
writing, it is not legal to distribute B15 in the United States,
though it was used as a supplement for some time in the 1970s. The
most common form of pangamic acid was calcium pangamate, but currently
it is dimethyl glycine (DMG), which may even be the active component
that has been hailed in the Soviet Union. Pangamic acid or DMG, when
used, is often taken with vitamin E and vitamin A. A common amount of
DMG is 50–100 mg. taken twice daily, usually with breakfast and
dinner. This level of intake may improve general energy levels,
support the immune system, and is also thought to reduce cravings for
alcohol and thus may be very helpful in moderating chronic alcohol
problems.
SOURCE: http://www.healthy.net/scr/Article.asp?Id=1925&xcntr=2
http://en.wikipedia.org/wiki/Pangamic_acid
------------------
I would like to see how much this can lower blood cholesterol compared
to e.g. niacin. Taka |
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| trigonometry1972 at (no spam) gmail.com |... |
| Posted: Thu Oct 15, 2009 6:14 am |
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Guest
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On Oct 15, 8:30 am, Taka <taka0... at (no spam) gmail.com> wrote:
[quote:70cb97f5db]Vitamin B15 -- Pangamic Acid
This is still a fairly controversial "vitamin." The quotation marks
suggest that we are not sure whether it is a vitamin. It has not yet
been shown to be essential in the diet (vitamins must be supplied from
external sources), and no symptoms or deficiency diseases are clearly
revealed when consumption is restricted. The FDA has been concerned
about the wide range of medical conditions treated with it, primarily
in other countries, and therefore pangamic acid is not readily
available to the U.S. consumer. Because most of the information about
pangamic acid is dated and is mainly from European and former Soviet
Union research, I discuss this substance here mainly for
completeness.
The former Soviet Union had been the most enthusiastic about pangamic
acid, feeling that it is a very important nutrient with physiological
actions that can treat a multitude of symptoms and diseases. Soviet
scientists had shown that pangamic acid supplementation can reduce the
buildup of lactic acid in athletes and thereby lessen muscle fatigue
and increase endurance. It had been used regularly and commonly in the
Soviet Union for many problems, including alcoholism and drug
addiction; mental problems such as those of aging and senility,
minimal brain damage in children, autism, and schizophrenia; heart
disease and high blood pressure; diabetes; skin diseases; liver
disease; and chemical poisonings.
As I said, the FDA has taken pangamic acid products off the market.
Dimethyl glycine (DMG) has been used by some people as a substitute as
it is thought to increase pangamic acid production in the body.
Dimethyl glycine combines with gluconic acid to form pangamic acid. It
is thought that the DMG is the active component of pangamic acid.
Sources: Pangamic acid was first isolated in 1951 by Drs. Ernest
Krebs, Sr. and Jr., from apricot kernels, along with laetrile, termed
vitamin B17. At that time, as today, they were not sure whether it was
essential to life.
Pangamic acid is also found in whole grains such as brown rice,
brewer’s yeast, pumpkin and sunflower seeds, and beef blood. Water and
direct sunlight may reduce the potency and availability of B15 in
these foods.
Functions: Pangamic acid is mainly a methyl donor, which helps in the
formation of certain amino acids such as methionine. It may play a
role in the oxidation of glucose and in cell respiration. By this
function, it may reduce hypoxia (deficient oxygen) in cardiac and
other muscles. Like vitamin E, it acts as an antioxidant, helping to
lengthen cell life through its protection from oxidation. Pangamic
acid is also thought to offer mild stimulation to the endocrine and
nervous systems, and by enhancing liver function, it may help in the
detoxification process.
Uses: Although many of these uses are not proven, there have been
reports of pangamic acid or DMG providing some benefits for a wide
range of symptoms, diseases, and metabolic problems. It may be useful
for such symptoms as headaches, angina and musculoskeletal chest pain,
shortness of breath, insomnia, and general stress—to be used, of
course, only after specific medical conditions are ruled out.
B15 has been shown to lower blood cholesterol, so it could provide
some nutritional support for those with high serum cholesterol or
cardiovascular problems or to reduce heart and blood vessel disease
risks. It may also help improve circulation and general oxygenation of
cells and tissues, so it may be used with any decreased cardiac or
brain functions. Pangamic acid may be helpful in general for
atherosclerosis and hypertension, America’s most common diseases.
In Europe vitamin B15 has been used to treat premature aging, because
of both its circulatory stimulus and its antioxidant effect. It is
felt to be a helpful protectant from pollutants, especially carbon
monoxide. Pangamic acid (and possibly DMG) support for anyone living
in a large polluted city or with a high-stress lifestyle could be a
wave of the future.
In Russia, a big use of pangamic acid has been for treating those with
alcohol problems, possibly reducing the craving. It has been reported
to diminish hangover symptoms when alcohol has been abused. B15 has
also been used to treat fatigue, as well as asthma and rheumatism, and
it may even have some antiallergic properties. Some child
psychiatrists have reported good results using pangamic acid in
disturbed children; it may help by stimulating speaking ability and
other mental functions. B15 may also be useful in problems of autism.
More studies regarding all claims of the benefits of pangamic acid
must be done, of course, to see which ones may be valid. But as of
now, it certainly is a "vitamin" or supplemental nutrient with
potential health benefits and research interest.
Deficiency and toxicity: There are no known toxic effects from even
high amounts of pangamic acid; 50–100 mg. (and even more) taken three
times daily have revealed no side effects. There are reports of
initial mild nausea with use of pangamates at high levels, but this
only lasts a few days.
There is limited information about deficiencies of pangamic acid.
There are no clear problems when it is absent in the diet, though some
diminished circulatory and oxygenation functions are possible.
Decreased cell respiration—that is, decreased oxygen use by cells—may
influence many other cellular functions which may lead to effects on
the heart.
Requirements: There is no RDA for pangamic acid. At the time of this
writing, it is not legal to distribute B15 in the United States,
though it was used as a supplement for some time in the 1970s. The
most common form of pangamic acid was calcium pangamate, but currently
it is dimethyl glycine (DMG), which may even be the active component
that has been hailed in the Soviet Union. Pangamic acid or DMG, when
used, is often taken with vitamin E and vitamin A. A common amount of
DMG is 50–100 mg. taken twice daily, usually with breakfast and
dinner. This level of intake may improve general energy levels,
support the immune system, and is also thought to reduce cravings for
alcohol and thus may be very helpful in moderating chronic alcohol
problems.
SOURCE:http://www.healthy.net/scr/Article.asp?Id=1925&xcntr=2
http://en.wikipedia.org/wiki/Pangamic_acid
------------------
I would like to see how much this can lower blood cholesterol compared
to e.g. niacin. Taka
[/quote:70cb97f5db]
Why not just take betaine base? Aka N-trimethylgylcine.
n-DMG is the next metabolic step and carries fewer
methyl groups. TMG is great for lowering homocysteine levels.
But a mechanisms for lowering cholesterol doesn't
pop to mind at least with me not looking at refresher
materials.
Food yeast is good in that it contains things that aren't
yet understood...................................................Trig |
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| trigonometry1972 at (no spam) gmail.com |... |
| Posted: Thu Oct 15, 2009 10:13 am |
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Guest
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On Oct 15, 10:00 am, Mark Thorson <nos... at (no spam) sonic.net> wrote:
[quote:3eb28785a2]"trigonometry1... at (no spam) gmail.com |" wrote:
Food yeast is good in that it contains things that aren't
yet understood...................................................Trig
You could say the same thing about unidentifiable
roadkill. I wouldn't call that a plus.
[/quote:3eb28785a2]
But yeast tends to have higher levels  That sentence
was designed to piss off the reader off just a bit.
I've posted to MHA just too many times. Seriously, I'd guess
a tablespoonful of food yeast contains ~20 or 30 mcg
of l-5-methyltetrahydrofolate. And I might even have some basis for
the guess..........go figure.
The preceeding is an example.
You know the type to folic acid
your beloved FDA pulled from the market back
when it made the chance. Now it patented and owned by
Merck so for now it has some protection
from the likes of you at the price of being a bit more costly.
And road kill likely starts out as better meat
that the corn fed and by product fed beef
that comes from the market.
Trig
""'You'd better pay up old man or you will
have an "accident" or your shop will
have a fire." said the rackteer." |
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| Mark Thorson... |
| Posted: Thu Oct 15, 2009 11:00 am |
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Guest
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"trigonometry1972 at (no spam) gmail.com |" wrote:
[quote:42eae054ac]
Food yeast is good in that it contains things that aren't
yet understood...................................................Trig
[/quote:42eae054ac]
You could say the same thing about unidentifiable
roadkill. I wouldn't call that a plus. |
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