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| Science Forum Index » Medicine - Cancer Forum » Fish oil good and bad against melanoma... |
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| Herb Organick... |
 Posted: Thu Jun 11, 2009 7:47 pm |
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Guest
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There are quite a few studies on fish oil and it's components DHA and EPA
and their effects on melanoma (and other malignancies). Fish oil and/or it's
ingredients alone can potentially (and potently) suppress inflammation,
metastasis and angiogenesis in melanoma and they/it can also conversely (and
potently!) suppress the immune system and inhibit tumoricidal T cells and NK
cells too! To fish oil or not to fish oil that is the question! Here is one
example of many such studies. It doesn't seem to be just a matter of
indiscriminately adding the straight oil to your diet. There must be some
trick to optimize it's effects with dosage, timing, composition,
co-supplements to counteract it's negative effects and promote it's positive
ones, applicability to the stage and extent of disease etc.
http://www.ncbi.nlm.nih.gov/pubmed/11062743
1: Anticancer Res. 2000 Sep-Oct;20(5A):3195-203.
N-3 polyunsaturated fatty acids accentuate B16 melanoma growth and
metastasis through suppression of tumoricidal function of T cells and
macrophages.
Salem ML, Kishihara K, Abe K, Matsuzaki G, Nomoto K.
Department of Immunology, Kyushu University, Fukuoka, Japan.
mohamed-84 at (no spam) hotmall.com
BACKGROUND: The antitumor effects of the n-3 polyunsaturated fatty acids
(PUFAs) are still controversial and as yet undefined. MATERIALS AND METHODS:
EPA-28, a fish oil enriched with n-3 PUFAs including eicosapentaenoic and
docosahexaenoic acids, was administered subcutaneously into C57BL/6 mice
before and after subcutaneous inoculation of B16 melanoma cells. The effects
of EPA-28 on the antitumor activities of T cells and macrophages were
investigated. RESULTS: The treatment of the mice with EPA-28 before and
after the tumor inoculation enhanced the growth and metastasis of B16
melanoma and decreased the survival rate of the tumor-bearing mice. The
treatment also decreased the number of CD4+ T cells in the spleen and tumor
draining lymph nodes on day 14 after the tumor inoculation. Moreover, EPA-28
suppressed the antimelanoma cytolytic activity of T cells and macrophages of
the tumor-bearing mice. CONCLUSION: The results suggest that EPA-28
treatment increased both the growth and metastasis of B16 melanoma cells by
suppressing the cytolytic function of both T cells and macrophages.
PMID: 11062743 [PubMed - indexed for MEDLINE] |
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