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| Science Forum Index » Immunology Forum » Folic acid receptor autoantibodies, vitamin D3 and... |
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| Robert Miles... |
 Posted: Tue Jun 02, 2009 1:01 am |
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"Kofi" <kofi at (no spam) anon.un> wrote in message
news:kofi-5081C9.01541301062009 at (no spam) news.west.earthlink.net...
[quote:f2ad765f77]The FDA suspended manufacture of leucovorin (folinic acid) due to
quality issues in early March and since then, I've been off it and doing
rather poorly. Supposedly production has resumed, but I've only been
able to get one bottle. It's lasted about a week. Since folinic acid
has become key in a number of chemotherapies, its availability may
remain limited for a while.
[snip]
It also turns out that low folic acid levels lead to higher vitamin D3
catabolism [PMID 19450178] so if the CNS is deficient in folic acid,
vitamin D3 isn't going to function properly - leading to a drop in redox
capacity (e.g., low glutathione)/metals detoxification/neurogenesis,
loss of antiviral functions/cathelicidin, increased cancer risk and
probably autoimmune issues as well. But it's going to be invisible to
anybody checking strict serum levels. It makes me wonder if certain
vital infections don't deliberately stir up anti-folic acid receptor
antibodies to block the antiviral effects of vitamin D3 within the
nervous system itself.
[snip]
Given that my folinic acid supply will be sporadic for a while, does
anybody know where I can find an inexpensive, high dose folate
supplement - somewhere on the order of 10mg a day?
..[/quote:f2ad765f77]
I don't, but I'll pass along a little about what I've found about vitamin
metabolism lately. Vitamin B12 works together with a biochemical
produced from folic acid for some purposes. This suggests that it
may be worthwhile checking if the methylcobalamin form of vitamin
B12 (the only form able to enter the brain, and normally produced
in a few steps from the cyanocobalamin form normally used for
vitamin B12 supplements in the US) offers you any help in using
folic acid or folinic acid more efficiently, and therefore decreasing
the amount you need.
<http://www.webmd.com/a-to-z-guides/vitamin-b12-deficiency-anemia-topic-overview>
http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB12/
<http://www.mayoclinic.com/health/vitamin-deficiency-anemia/DS00325/DSECTION=causes>
Although methylcobalamin is available as a supplement, some
people have enough trouble absorbing any form of vitamin B12
that they need it delivered as injections. Since it's the normal
form of vitamin B12 supplements in Japan, looking for a Japanese
vitamin company may help.
I believe I've seen the brand name Methyl-B12 as one possibility.
Some information on vitamin B9, usually taken in the folic acid
form if you don't get enough from the folic acid added to most
bread:
http://www.spineuniverse.com/displayarticle.php/article963.html
http://www.drweil.com/drw/u/ART02809/vitamin-b9-folate.html
http://www.umm.edu/altmed/articles/vitamin-b9-000338.htm
I've forgotten the full name of the form of vitamin B9 which
can enter the brain, but I believe it includes tetrahydrofolate.
http://en.wikipedia.org/wiki/Tetrahydrofolate
http://en.wikipedia.org/wiki/Folic_acid
http://www.biocheminfo.org/klotho/html/tetrahydrofolate.html
<http://biocyc.org/META/NEW-IMAGE?type=COMPOUND&object=THF>
http://www.ncbi.nlm.nih.gov/pubmed/11752472
http://biocyc.org/META/new-image?object=FOLSYN-PWY
http://www.ebi.ac.uk/interpro/DisplayIproEntry?ac=IPR000672
http://www.nd.edu/~aseriann/thf.html
Vitamin D3 is closer to the form of vitamin D that the body
actually uses than the vitamin D2 form often used for vitamin D
supplements. Vitamin D is better absorbed if taken along with
some oil; therefore the forms of vitamin D3 already dissolved
in oil are especially active.
Robert Miles |
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| Kofi... |
| Posted: Tue Jun 02, 2009 11:36 pm |
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[quote:ca020c75e0]I don't, but I'll pass along a little about what I've found about vitamin
metabolism lately. Vitamin B12 works together with a biochemical
produced from folic acid for some purposes.
[/quote:ca020c75e0]
I've been taking magnesium, methyl-B12 and folinic acid shots together
for several years now, since I read a paper on homocysteine blocking
GABAergic transmission. Once I read the paper, it seemed the right
combination to throw against my neuropathy and it worked quite well.
All of the methylators I tried from SAMe to TMG worked well too, so that
reinforced my decision.
[quote:ca020c75e0]Vitamin D3 is closer to the form of vitamin D that the body
actually uses than the vitamin D2 form often used for vitamin D
supplements. Vitamin D is better absorbed if taken along with
some oil; therefore the forms of vitamin D3 already dissolved
in oil are especially active.
[/quote:ca020c75e0]
I've been taking D3 for a while too. It was only when I went off
folinic acid that the D3 became ineffective. |
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| Joesepi... |
| Posted: Wed Jun 03, 2009 9:00 pm |
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I found mnay health benefits from taking magnesium over a few years. My eyes
became very clear and pure, the iris colour turned from brown to almost
blue, as they are underneath, allergies disappeared and my overall feeling
was wonderful.
However the magnesium oxide was too much after some time and I developed
heel spurs on the bottoms and under the achillies tendons. These have lasted
for a few years despite attempting to grind them off with external tools,
ice and heat.
I have discovered that many minerals have a similar effect on my health and
have concluded the change in body pH is what causes most of it. Of course
mineral balance has to be monitored closely and not overdo any particular
mineral, as well as using cofactors, I would be sure. We don't want any
depleted metabolic pathways, now, either.
L-Lysine can assist as a cofactor in magnesium and calcium metabolism as
well as general immune function.
"Kofi" <kofi at (no spam) anon.un> wrote in message
news:kofi-0B4372.23360502062009 at (no spam) news.east.earthlink.net...
[quote:31d92bc27e]I've been taking magnesium, methyl-B12 and folinic acid shots together
for several years now, since I read a paper on homocysteine blocking
GABAergic transmission. Once I read the paper, it seemed the right
combination to throw against my neuropathy and it worked quite well.
All of the methylators I tried from SAMe to TMG worked well too, so that
reinforced my decision.
Vitamin D3 is closer to the form of vitamin D that the body
actually uses than the vitamin D2 form often used for vitamin D
supplements. Vitamin D is better absorbed if taken along with
some oil; therefore the forms of vitamin D3 already dissolved
in oil are especially active.
I've been taking D3 for a while too. It was only when I went off
folinic acid that the D3 became ineffective.[/quote:31d92bc27e] |
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