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Science Forum Index » Medicine - Cardiology Forum » Aspartame Induced Arrhythmias and Sudden Death, HJ...
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| Rich Murray... |
 Posted: Thu Jun 26, 2008 7:09 pm |
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Aspartame Induced Arrhythmias and Sudden Death, HJ Roberts 2004:
Murray 2008.06.26
http://rmforall.blogspot.com/2008_06_01_archive.htm
Thursday, June 26, 2008
http://groups.yahoo.com/group/aspartameNM/message/1544
____________________________________________________
Aspartame Induced Arrhythmias and Sudden Death
By H. J. Roberts, M.D., F.A.C.P., F.C.C.P.
E-Mail: HJrobertsmd at (no spam) aol.com
(c)2004 by H. J. Roberts, M.D.
A recent extensive review of sudden death in young athletes (1)
made no mention of aspartame as a primary cause or suspected
contributory factor, especially when demonstrable pathology was
absent.
This issue has assumed great public health importance because
"diet" products containing this chemical are being consumed by
over two-thirds of the population -- especially weight-conscious
persons.
I have repeatedly reported the serious cardiovascular,
'neuropsychiatric, metabolic and other adverse effects of
aspartame products. (2-4)
Among the first 1200 aspartame reactors in my data base,
193 (16%) had symptomatic arrhythmia,
85 (7%) atypical chest pain, and
64 (5%) recent or aggravated hypertension.
One hypertensive patient developed complete heart block within
hours after consuming his first diet cola.
Another had undergone unsuccessful radio frequency ablations in the
heart before awareness of having aspartame disease.
Pheochromocytoma was suspected in several aspartame reactors.
The issue of sudden death related to aspartame and its breakdown
products has been raised a number of times, particularly among
previously well individuals using such products... including pilots
and drivers, (3,4,6) and athletes.
I have detailed the release of norepinephrine, epinephrine, dopamine
and free methanol by aspartame; a host of pertinent-related
pathophysiologic conditions,
(e.g., cumulative formaldehyde adducts derived from aspartame in
tissue proteins and nucleic acids; excessive insulin release);
direct oropharyngeal absorption from gum, breath fresheners and
other products; and the increasing problem of aspartame addiction.
(4-7)
The likelihood of pulmonary hypertension induced by the
vasoconstrictive effects of aspartame products also has been
considered. (5)
It is relevant that unexplained dyspnea was experienced by 110
aspartame reactors, usually with prompt improvement after
abstinence.
Moreover, primary pulmonary hypertension was found at autopsy
in a 27 year old female aspartame reactor.
The lack of familiarity of most physicians and medical examiners
with the foregoing considerations can have serious legal
consequences.
A case in point is that of a young woman (also a Sunday School
teacher) who has been sentenced to serve 50 years in a Virginia
prison for allegedly poisoning her husband with methyl alcohol.
[ Diane and Charles Fleming ]
Elevated methanol blood concentrations were found postmortem in
this body builder/basketball player who drank ten diet drinks and
other aspartame products daily.
She remains incarcerated despite affidavits indicating that 10% of
aspartame becomes free methyl alcohol after consumption.
The need for clinicians and corporate-neutral investigators to
evaluate the contributory role of aspartame in cardiopulmonary
disorders and sudden death, and drug interactions with aspartame,
is underscored by the frequency of persons dying unexpectedly
being categorized as "death due to causes yet to be determined."
One interested resident of Orange county (California) found 192
persons listed in this category between July 11 and November 15,
2003 according to the Orange county Register.
References:
Maron BJ,
Sudden death in young athletes,
N Engl J Med 2003; 349: 1064-1075
Roberts HJ,
Reactions to aspartame containing products: 551 cases,
J Appl Nutr l988; 40: 86-94
Roberts HJ, Aspartame (NutraSweet): Is It Safe?
Philadelphia, The Charles Press, 1989.
Roberts HJ,
Aspartame Disease: An Ignored Epidemic.
West Palm Beach, Sunshine Sentinel Press, 2001
Roberts HJ,
Aspartame-induced dyspnea and pulmonary hypertension,
Townsend Letter for Doctors & Patients 2003; 237 (January): 64-65
Roberts HJ,
Ignored Health Hazards for Pilots and Drivers.
West Palm Beach, Sunshine Sentinel Press, 1998.
Roberts HJ, Aspartame (NutraSweet) addiction,
Townsend Letter for Doctors & Patients, 2000; 198 (January): 52-57
H. J. Roberts, MD, FACP, FCCP
Palm Beach Institute for Medical Research
P. O. Box 17799
West Palm Beach, Florida 33416 USA
____________________________________________________
http://www.dorway.com/tldaddic.html 5-page review
Roberts HJ Aspartame (NutraSweet) addiction.
Townsend Letter 2000 Jan; HJRobertsMD at (no spam) aol.com
http://www.sunsentpress.com/ sunsentpress at (no spam) aol.com
Sunshine Sentinel Press P.O.Box 17799 West Palm Beach, FL 33416
800-814-9800 561-588-7628 561-547-8008 fax
http://groups.yahoo.com/group/aspartameNM/message/669
1038-page medical text "Aspartame Disease: An Ignored Epidemic"
published May 30 2001 $ 60.00 postpaid data from 1200 cases
available at http://www.amazon.com
over 600 references from standard medical research
http://groups.yahoo.com/group/aspartameNM/message/790
Moseley: review Roberts "Aspartame Disease: An Ignored Epidemic":
Murray 2002.02.07
Roberts, Hyman J., 1924- ,
Useful insights for diagnosis, treatment and public heath: an updated
anthology of original research, 2002, 798 pages,
aspartame disease, pages 627-685, 778-780
http://groups.yahoo.com/group/aspartameNM/message/859
Roberts: the life work of a brilliant clinician: aspartame toxicity:
Murray 2002.08.02
____________________________________________________
re "A Few too Many", Joan Acocella, The New Yorker, long review of
hangover
research 2008.05.26 -- same levels of formaldehyde and formic acid in
FEMA
trailers and other sources (aspartame, dark wines and liquors, tobacco
smoke): Murray 2008.06.05
http://rmforall.blogspot.com/2008_06_01_archive.htm
Thursday, June 5, 2008
http://groups.yahoo.com/group/aspartameNM/message/1541
formaldehyde and formic acid in FEMA trailers and other sources
(aspartame,
dark wines and liquors, tobacco smoke): Murray 2008.01.30
http://rmforall.blogspot.com/2008_01_01_archive.htm
Wednesday, January 30, 2008
http://groups.yahoo.com/group/aspartameNM/message/1508
The FEMA trailers give about the same amount of formaldehyde and
formic acid
daily as from a quart of dark wine or liquor, or two quarts (6 12-oz
cans)
of aspartame diet soda, from their over 1 tenth gram methanol impurity
(one
part in 10,000), which the body quickly makes into formaldehyde and
then
formic acid -- enough to be the major cause of "morning after" alcohol
hangovers.
Methanol and formaldehyde and formic acid also result from many fruits
and
vegetables, tobacco and wood smoke, heater and vehicle exhaust,
household
chemicals and cleaners, cosmetics, and new cars, drapes, carpets,
furniture,
particleboard, mobile homes, buildings, leather... so all these
sources add
up and interact with many other toxic chemicals.
methanol impurity in alcohol drinks [ and aspartame ] is turned into
neurotoxic formic acid, prevented by folic acid, re Fetal Alcohol
Syndrome,
BM Kapur, DC Lehotay, PL Carlen at U. Toronto, Alc Clin Exp Res 2007
Dec.
plain text: detailed biochemistry, CL Nie et al. 2007.07.18: Murray
2008.02.24
http://rmforall.blogspot.com/2008_02_01_archive.htm
Sunday, February 24, 2008
http://groups.yahoo.com/group/aspartameNM/message/1524
"Of course, everyone chooses, as a natural priority, to enjoy peace,
joy,
and love by helping to find, quickly share, and positively act upon
evidence
about healthy and safe food, drink, and environment."
Rich Murray, MA Room For All rmforall at (no spam) comcast.net
505-501-2298 1943 Otowi Road, Santa Fe, New Mexico 87505
http://RMForAll.blogspot.com new primary archive
http://groups.yahoo.com/group/aspartameNM/messages
group with 126 members, 1,544 posts in a public archive
http://groups.yahoo.com/group/aspartame/messages
group with 1,119 members, 22,762 posts in public archive
http://www.newyorker.com/reporting/2008/05/26/080526fa_fact_acocella?currentPage=all
Annals Of Drinking
A Few Too Many
Is there any hope for the hung over?
by Joan Acocella May 26, 2008 themail at (no spam) newyorker.com
"Wayne Jones, of the Swedish National Laboratory of Forensic Medicine"
[ http://groups.yahoo.com/group/aspartameNM/message/1469
highly toxic formaldehyde, the cause of alcohol hangovers, is
made by the body from 100 mg doses of methanol from
dark wines and liquors, dimethyl dicarbonate, and aspartame:
Murray 2007.08.31 ]
http://groups.yahoo.com/group/aspartameNM/message/1286
methanol products (formaldehyde and formic acid) are main cause
of alcohol hangover symptoms [same as from similar amounts of
methanol, the 11% part of aspartame]: YS Woo et al, 2005 Dec:
Murray 2006.01.20
Addict Biol. 2005 Dec;10(4): 351-5.
Concentration changes of methanol in blood samples during
an experimentally induced alcohol hangover state.
Woo YS, Yoon SJ, Lee HK, Lee CU, Chae JH, Lee CT, Kim DJ.
Chuncheon National Hospital, Department of Psychiatry,
The Catholic University of Korea, Seoul, Korea.
[ Han-Kyu Lee ]
A hangover is characterized by the unpleasant physical and mental
symptoms that occur between 8 and 16 hours after drinking alcohol.
After inducing experimental hangover in normal individuals,
we measured the methanol concentration prior to
and after alcohol consumption
and we assessed the association between the hangover condition
and the blood methanol level.
A total of 18 normal adult males participated in this study.
They did not have any previous histories of psychiatric
or medical disorders.
The blood ethanol concentration prior to the alcohol intake
(2.26+/-2.0 was not significantly different from that
13 hours after the alcohol consumption (3.12+/-2.3.
However, the difference of methanol concentration
between the day of experiment (prior to the alcohol intake)
and the next day (13 hours after the alcohol intake)
was significant (2.62+/-1.33/l vs. 3.88+/-2.10/l, respectively).
A significant positive correlation was observed
between the changes of blood methanol concentration
and hangover subjective scale score increment when covarying
for the changes of blood ethanol level (r=0.498, p<0.05).
This result suggests the possible correlation of methanol
as well as its toxic metabolite to hangover. PMID: 16318957
[ The toxic metabolite of methanol is formaldehyde, which in turn
partially becomes formic acid -- both potent cumulative toxins
that are the actual cause of the toxicity of methanol.]
This study by Jones AW (1987) found next-morning hangover
from red wine with 100 to 150 mg methanol
(9.5 % w/v ethanol, 100 mg/l methanol, 0.01 %).
Fully 11% of aspartame is methanol --
1,120 mg aspartame in 2 L diet soda,
almost six 12-oz cans, gives 123 mg methanol (wood alcohol).
Pharmacol Toxicol. 1987 Mar; 60(3): 217-20.
Elimination half-life of methanol during hangover.
Jones AW. wayne.jones at (no spam) RMV.se;
Department of Forensic Toxicology,
University Hospital, SE-581 85 Linkoping, Sweden.
This paper reports the elimination half-life of methanol in human
volunteers.
Experiments were made during the morning after the subjects had
consumed 1000-1500 ml red wine
(9.5 % w/v ethanol, 100 mg/l methanol)
the previous evening. [ 100 to 150 mg methanol ]
The washout of methanol from the body
coincided with the onset of hangover.
The concentrations of ethanol and methanol in blood were
determined indirectly by analysis of end-expired alveolar air.
In the morning when blood-ethanol dropped
below the Km of liver alcohol dehydrogenase (ADH)
of about 100 mg/l (2.2 mM),
the disappearance half-life of ethanol was 21, 22, 18 and 15 min.
in 4 test subjects respectively.
The corresponding elimination half-lives of methanol
were 213, 110, 133 and 142 min. in these same individuals.
The experimental design outlined in this paper can be used
to obtain useful data on elimination kinetics of methanol
in human volunteers without undue ethical limitations.
Circumstantial evidence is presented to link methanol
or its toxic metabolic products, formaldehyde and formic acid,
with the pathogenesis of hangover. PMID: 3588516 ]
[ for more, see URL..... ]
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