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Science Forum Index » Life Extension Forum » Zinc supplementation decreases incidence of infections...
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 Posted: Wed Jun 11, 2008 11:01 am |
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Am J Clin Nutr. 2007 Mar;85(3):837-44. Links
Zinc supplementation decreases incidence of infections in the elderly:
effect of zinc on generation of cytokines and oxidative stress.Prasad
AS, Beck FW, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJ.
Wayne State University School of Medicine, Detroit, MI, and the
University of Michigan, Ann Arbor, MI 48201, USA. prasada at (no spam) karmanos.org
BACKGROUND: Zinc deficiency, cell-mediated immune dysfunction,
susceptibility to infections, and increased oxidative stress have been
observed in elderly subjects (ie, those >55 y old). Zinc is an
effective antiinflammatory and antioxidant agent. OBJECTIVES: The
primary objective was to determine the effect of zinc on the incidence
of total infections in healthy elderly subjects. The secondary
objective was to determine the effect of zinc on cytokines and
oxidative stress markers. DESIGN: A randomized, double-blind, placebo-
controlled trial of zinc supplementation was conducted in elderly
subjects. Fifty healthy subjects of both sexes aged 55-87 y and
inclusive of all ethnic groups were recruited for this study from a
senior center. The zinc-supplemented group received zinc gluconate (45
mg elemental Zn/d) orally for 12 mo. Incidence of infections during
the supplementation period was documented. The generation of
inflammatory cytokines, T helper 1 and T helper 2 cytokines, and
oxidative stress markers and the plasma concentrations of zinc were
measured at baseline and after supplementation. RESULTS: Compared with
a group of younger adults, at baseline the older subjects had
significantly lower plasma zinc, higher ex vivo generation of
inflammatory cytokines and interleukin 10, and higher plasma oxidative
stress markers and endothelial cell adhesion molecules. The incidence
of infections and ex vivo generation of tumor necrosis factor alpha
and plasma oxidative stress markers were significantly lower in the
zinc-supplemented than in the placebo group. Plasma zinc and
phytohemagglutin-induced interleukin 2 mRNA in isolated mononuclear
cells were significantly higher in the zinc-supplemented than in the
placebo group. CONCLUSIONS: After zinc supplementation, the incidence
of infections was significantly lower, plasma zinc was significantly
higher, and generation of tumor necrosis factor alpha and oxidative
stress markers was significantly lower in the zinc-supplemented than
in the placebo group.
PMID: 17344507 [PubMed - indexed for MEDLINE] |
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