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Science Forum Index » Life Extension Forum » Zinc supplementation in the elderly reduces...
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 Posted: Wed Jun 11, 2008 10:59 am |
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Rejuvenation Res. 2008 Feb;11(1):227-37. Links
Zinc supplementation in the elderly reduces spontaneous inflammatory
cytokine release and restores T cell functions.Kahmann L, Uciechowski
P, Warmuth S, Plümäkers B, Gressner AM, Malavolta M, Mocchegiani E,
Rink L.
Institute of Immunology, RWTH Aachen University Hospital, Aachen,
Germany.
Aging is associated with low-grade inflammation on the one hand and
mild zinc deficiency on the other. These conditions contribute to
decreased immune functions, resulting in increased incidences of
infections and autoimmune diseases. The aim of this study was to give
more insight into the question, to what extent is low-grade
inflammation caused by zinc deficient status. Here we report the
effect of improved intracellular zinc status on low-grade inflammatory
activity in 19 healthy elderly subjects. Our experiments show that
adjustment of labile zinc by moderate zinc supplementation reduces
spontaneous cytokine release and defects in termination of
inflammatory activity. This results in reduced amounts of unspecific
preactivated T cells and leads to improved T cell response upon
mitogenic stimulation. Therefore, in contrast to other anti-
inflammatory drugs, zinc does not suppress, but improves immune
reaction upon pathogen invasion. These results suggest that mildly
zinc-deficient, healthy elderly subjects might benefit from moderate
zinc supplementation due to a more balanced immune response with
reduced incidences of infections and autoimmune diseases.
PMID: 18279033 [PubMed - in process] |
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