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Science Forum Index » Life Extension Forum » Effects of cognac on coronary flow reserve and plasma...
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| rs1000b at (no spam) yahoo.com... |
 Posted: Fri Jun 06, 2008 7:49 am |
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Cardiovasc Ultrasound. 2008 Jun 3;6(1):25. [Epub ahead of print]
Effects of cognac on coronary flow reserve and plasma antioxidant
status in healthy young men.
Kiviniemi TO, Saraste A, Toikka JO, Saraste M, Raitakari OT, Parkka
JP, Lehtimaki T, Hartiala JJ, Viikari J, Koskenvuo JW.
ABSTRACT: BACKGROUND: The cardioprotective effects of certain
alcoholic beverages are partly related to their polyphenol content,
which may improve the vasodilatory reactivity of arteries. Effect of
cognac on coronary circulation, however, remains unknown. The purpose
of this randomized controlled cross-over study was to determine
whether moderate doses of cognac improve coronary reactivity as
assessed with cold pressor testing (CPT) and coronary flow reserve
(CFR) measument. METHODS: Study group consisted of 23 subjects.
Coronary flow velocity and epicardial diameter was assessed using
transthoracic echocardiography at rest, during CPT and adenosine
infusion-derived CFR measurements before drinking, after a moderate
(1.2 +/- 0.1 dl) and an escalating high dose (total amount 2.4 +/- 0.3
dl) of cognac. To explore the bioavailability of antioxidants, the
antioxidant contents of cognac was measured and the absorption from
the digestive tract was verified by plasma antioxidant capacity
determination. RESULTS: Serum alcohol levels increased to 1.2 +/- 0.2
per thousand and plasma antioxidant capacity from 301 +/- 43.9 umol/l
to 320 +/- 25.0 umol/l by 7.6 +/- 11.8%, (p=0.01) after high doses of
cognac. There was no significant change in flow velocity during CPT
after cognac ingestion compared to control day. CFR was 4.4 +/- 0.8,
4.1 +/- 0.9 (p=NS), and 4.5 +/- 1.2 (p=NS) before drinking and after
moderate and high doses on cognac day, and 4.5 +/- 1.4, and 4.0 +/-
1.2 (p=NS) on control day. CONCLUSIONS: Cognac increased plasma
antioxidant capacity, but it had no effect on coronary circulation in
healthy young men.
PMID: 18522727 [PubMed - as supplied by publisher] |
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