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| jay... |
 Posted: Thu May 15, 2008 6:46 am |
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What supplements provide relief from polyneuropathy? Would the
following be the most important? Already doing paleo-type diet,
moderate exercise and multi-vitamins.
Benfotiamine
Vitamin B6 (P-5-P)
R-Lipoic Acid
NAC
Acetyl-L-Carnitine |
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| jay... |
| Posted: Thu May 15, 2008 10:47 am |
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Quote: ... Evening Primrose Oil is not on your list.
That's the biggie. I think...
Thanks.
Quote: I don't know what NAC is.
Inhibition of development of peripheral neuropathy in streptozotocin-
induced diabetic rats with N-acetylcysteine.
N-acetylcysteine (NAC) is a precursor of glutathione (GSH) synthesis,
a free radical scavenger and an inhibitor of tumour necrosis factor
alpha (TNF). Because these functions might be beneficial in diabetic
complications, in this study we examined whether NAC inhibits
peripheral neuropathy. Motor nerve conduction velocity (MNCV) was
significantly decreased in streptozotocin-induced-diabetic Wistar rats
compared to control rats. Oral administration of NAC reduced the
decline of MNCV in diabetic rats. Structural analysis of the sural
nerve disclosed significant reduction of fibres undergoing myelin
wrinkling and inhibition of myelinated fibre atrophy in NAC-treated
diabetic rats. NAC treatment had no effect on blood glucose levels or
on the nerve glucose, sorbitol and cAMP contents, whereas it corrected
the decreased GSH levels in erythrocytes, the increased lipid peroxide
levels in plasma and the increased lipopolysaccharide-induced TNF
activity in sera of diabetic rats. Thus, NAC inhibited the development
of functional and structural abnormalities of the peripheral nerve in
streptozotocin-induced diabetic rats. PMID: 8721770 |
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| jay... |
| Posted: Thu May 15, 2008 11:51 am |
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Quote: ... Evening Primrose Oil is not on your list.
Below abstract says, in general LA more effective, but EPO/GLA better
for ileum related neuropathy. Is there any commonly available food
with GLA?
The effectiveness of treatments of diabetic autonomic neuropathy is
not the same in autonomic nerves supplying different organs.
The aim of the study was to investigate antioxidant (alpha-lipoic acid
[LA]) and gamma-linolenic acid treatments in the prevention of changes
in autonomic nerves induced in streptozotocin-diabetic rats. Autonomic
nerves supplying the heart, penis, and gut were examined using
immunohistochemical and biochemical techniques. LA and gamma-linolenic
acid (present in evening primrose oil [EPO]) were administered as
dietary supplements ( approximately 80 and 200 mg. kg(-1). day(-1),
respectively). LA treatment prevented the diabetes-induced decrease of
norepinephrine (NA) in the heart and of type I nitric oxide synthase
(NOS-I) expression in erectile tissue of the penis but failed to
prevent diabetes-induced changes in NA-, vasoactive intestinal
polypeptide-, or calcitonin gene-related peptide-containing nerves
supplying the ileum. LA partially prevented and EPO totally prevented
the increase in NOS-I activity induced by diabetes in the ileum. EPO
treatment failed to prevent any other diabetes-induced changes in the
heart, penis, or ileum. These results demonstrate that, whereas LA
treatment is more effective than EPO in preventing diabetes-induced
changes in autonomic nerves, the effectiveness of LA treatment varies
with the target organ studied. Diabetes-induced changes in nerves
supplying the ileum are more resistant to treatment than those of the
heart and penis.
PMID: 12502507 |
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| Màck©®... |
| Posted: Thu May 15, 2008 1:18 pm |
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On Thu, 15 May 2008 09:46:29 -0700 (PDT), jay <jaym1212 at (no spam) hotmail.com>
wrote:
Quote: What supplements provide relief from polyneuropathy? Would the
following be the most important? Already doing paleo-type diet,
moderate exercise and multi-vitamins.
Benfotiamine
Vitamin B6 (P-5-P)
R-Lipoic Acid
NAC
Acetyl-L-Carnitine
I can get you an incredible deal on the Statue of Liberty, 25% off the
cheapest price you can find from anyone else. |
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| Julie Bove... |
| Posted: Thu May 15, 2008 3:09 pm |
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"jay" <jaym1212 at (no spam) hotmail.com> wrote in message
news:739091c9-61a5-4257-844a-cbc2e72bd0e6 at (no spam) r66g2000hsg.googlegroups.com...
Quote: What supplements provide relief from polyneuropathy? Would the
following be the most important? Already doing paleo-type diet,
moderate exercise and multi-vitamins.
Benfotiamine
Vitamin B6 (P-5-P)
R-Lipoic Acid
NAC
Acetyl-L-Carnitine
I don't know what NAC is. But Evening Primrose Oil is not on your list.
That's the biggie. I think... |
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| Tiger_Lily... |
| Posted: Thu May 15, 2008 5:09 pm |
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| Andrew B. Chung, MD/PhD... |
| Posted: Fri May 16, 2008 11:55 am |
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timoth... at (no spam) my-deja.com wrote:
Quote:
Here is the result of small clinical trials in humans in Germany as of
1999. There may be more positive evidence since then. High pyridoxine
supplementation usually in excess of 600 mg./day has resulted in
neuropathy in a small number of people. They were taking it for carpal
tunnel syndrome. They were also taking it w/o other B vitamins and the
condition was reversible. Personally I have taken 1000 mg/d for
extended periods w/o side effects. It's probably best to steer clear
of supplementation IMHO.
A GI tract including its bacterial flora that is processing an optimal
amount of food each day is one that is capable, with GOD's blessing,
of extracting and supplying the required nutrients (macro, micro, and
trace) in a precisely regulated fashion to meet the specific highly
variable requirements of the body.
By GOD's design, there is one optimal amount for every adult as
denoted by the Hebrew word "omer" (Exodus 16:16).
Have been eating HIS optimal amount since 1997 so that I can
personally testify that GOD is absolutely right in HIS design.
Laus Deo ! ! !
Be hungry... be healthy... be hungrier... be euglycemic...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17? |
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| jay... |
| Posted: Fri May 16, 2008 1:39 pm |
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Quote: What supplements provide relief from polyneuropathy?
Nobody seems to have mentioned the most obvious one, thiamine!
My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is
this too much? |
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| Marshall Price... |
| Posted: Fri May 16, 2008 4:40 pm |
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jay wrote:
Quote: What supplements provide relief from polyneuropathy? Would the
following be the most important? Already doing paleo-type diet,
moderate exercise and multi-vitamins.
Benfotiamine
Vitamin B6 (P-5-P)
R-Lipoic Acid
NAC
Acetyl-L-Carnitine
Nobody seems to have mentioned the most obvious one, thiamine!
--
Marshall Price of Miami
Known to Yahoo as d021317c |
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| Nicky... |
| Posted: Fri May 16, 2008 5:12 pm |
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On Fri, 16 May 2008 17:40:01 -0400, Marshall Price
<d021317c at (no spam) yahoo.com> wrote:
Quote: jay wrote:
What supplements provide relief from polyneuropathy? Would the
following be the most important? Already doing paleo-type diet,
moderate exercise and multi-vitamins.
Benfotiamine
Vitamin B6 (P-5-P)
R-Lipoic Acid
NAC
Acetyl-L-Carnitine
Nobody seems to have mentioned the most obvious one, thiamine!
Benfotiamine is a better source than thiamine, it's got more
absorption sites.
Nicky.
T2 dx 05/04 + underactive thyroid
D&E, 100ug thyroxine
Last A1c 5.6% BMI 25 |
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| trigonometry1972 at (no spam) gmail.com |... |
| Posted: Fri May 16, 2008 11:42 pm |
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On May 16, 4:39 pm, jay <jaym1... at (no spam) hotmail.com> wrote:
Quote: What supplements provide relief from polyneuropathy?
Nobody seems to have mentioned the most obvious one, thiamine!
My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is
this too much?
Naw, there is research comparing benforiamine and thiamine
and the doses needed of thiamine were 10 to 15 times that
for a modest competative response. The benfotiamine
was more effective at lower dose. As I recall the
therapeutic dose of benfotiamine was 300 milligrams.
Huge numbers take 50 to 100 mg of thiamine daily and
people aren't dying in the streets.
With all B-vitamins one is well advised to take not one
vitamin but all the B-vitamins and even some magnesium
during the day. A high level one can increase
the need for higher levels of some of the others.
I recently say article on this point having to
do with folic acid and cobalamin. And I've
read this comment about thiamine and the other Bs,
and B-6 and magnesium as examples.
This is also true with the fat soluble vitamins.
If one takes E then one should take K.
If one takes D then one should take K.
If one takes A then one should likely take D.
If one take A one should also take E.
If one take alpha tocopherol then one
should take gamma tocopherol and the others as well.
And I suppose a mixture of K1 and K2 will
likely have some merits.
And most multi vitamins just don't cut especially
the most massively marketed ones i.e. One a Day,
Centrum and their ilk. |
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| Andrew B. Chung, MD/PhD... |
| Posted: Sat May 17, 2008 10:56 pm |
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Marshall Price wrote:
Quote: Andrew, in the Holy Spirit, boldly wrote:
friend jay wrote:
Be hungry... be healthy... be hungrier... be healthier...
Good advice. I try to fast on Sundays.
The formation of peripheral myelin protein 22 aggregates is hindered
by the enhancement of autophagy and expression of cytoplasmic
chaperones.
The accumulation of misfolded proteins is associated with various
neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is
a hereditary neuropathy-linked, short-lived molecule that forms
aggresomes when the proteasome is inhibited or the protein is mutated.
We previously showed that the removal of pre-existing PMP22 aggregates
is assisted by autophagy. Here we examined whether the accumulation of
such aggregates could be suppressed by experimental induction of
autophagy and/or chaperones. Enhancement of autophagy during
proteasome inhibition hinders protein aggregate formation and
correlates with a reduction in accumulated proteasome substrates.
Conversely, simultaneous inhibition of autophagy and the proteasome
augments the formation of aggregates. An increase of heat shock
protein levels by geldanamycin treatment or heat shock preconditioning
similarly hampers aggresome formation. The beneficial effects of
autophagy and chaperones in preventing the accumulation of misfolded
PMP22 are additive and provide a potential avenue for therapeutic
approaches in hereditary neuropathies linked to PMP22 mutations. PMID:
17174099
Fasting can result in hyperketonemia, which suppresses hunger.
It is only when we are hungrier, that our bodies "burn" away the VAT
(black fat):
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17?
Those links don't mention "VAT" or "black."
http://groups.google.com/group/sci.med.cardiology/msg/f20e435e3ec529db?
Be hungry... be healthy... be hungrier... be euglycemic...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17? |
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| Andrew B. Chung, MD/PhD... |
| Posted: Sat May 17, 2008 11:01 pm |
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Marshall Price wrote:
Quote: Andrew, in the Holy Spirit, wrote in part:
By GOD's design, there is one optimal amount for every adult as
denoted by the Hebrew word "omer" (Exodus 16:16).
Why not save us the trouble of looking it up?
"Each one is to gather as much as he needs. Take an omer for each
person you have in your tent." -- LORD Almighty GOD (Exodus 16:16)
16 + 16 = 32
Reminding us that the one optimal amount is 32 ounces.
Be hungry... be healthy... be hungrier... be euglycemic...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17? |
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| Marshall Price... |
| Posted: Sun May 18, 2008 3:31 am |
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Andrew B. Chung, MD/PhD wrote:
Quote: By GOD's design, there is one optimal amount for every adult as
denoted by the Hebrew word "omer" (Exodus 16:16).
Why not save us the trouble of looking it up?
--
Marshall Price of Miami
Known to Yahoo as d021317c |
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| Marshall Price... |
| Posted: Sun May 18, 2008 4:02 am |
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jay wrote:
Quote: What supplements provide relief from polyneuropathy?
Nobody seems to have mentioned the most obvious one, thiamine!
My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is
this too much?
It sounds like too much to me, but many people take that much, or
more. The multi-vitamin-mineral tablets I take afford about one DV
(that is, 100%) for each vitamin and mineral, except for the major
minerals. (For thiamine, that means 1.5mg.)
But I also take a few vitamins "on the side" for specific purposes,
and I expect to get most of my nutrients from food, not to mention the
zillions of honored guest symbiotes in my digestive tract. I'd be lost
without them. ;-)
--
Marshall Price of Miami
Known to Yahoo as d021317c |
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