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Science Forum Index » Life Extension Forum » Supplements for Neuropathy...
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| Truth... |
Posted: Sun May 18, 2008 9:28 am |
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Guest
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On May 18, 1:31 am, Marshall Price <d0213... at (no spam) yahoo.com> wrote:
Quote: Andrew B. Chung, MD/PhD wrote:
By GOD's design, there is one optimal amount for every adult as
denoted by the Hebrew word "omer" (Exodus 16:16).
Why not save us the trouble of looking it up?
--
Marshall Price of Miami
Known to Yahoo as d021317c
Chung has been told many times that scholars agree that an omer is a
biblical measure of volume equivalent to approximately 2 liters or
quarts. Yet he is fixated on the fact that the verse mentioning an
omer as being the right amount of food for the Israelites wandering in
the desert is Exodus 16:16. He therefore twists this to be numerology
"proof" that an omer is 2 pounds or 32 ounces.
Chung initially fixated on the 2 pounds per person per day diet when
he saw some IMAX film about Everest climbers and mistakenly came away
with the idea that those climbers ate only 2 pounds of food per day.
As his mental illness progressed and he became more fixated on quasi-
Christianity, this 2 pounds a day morphed from being inspired by the
IMAX Everest film into being inspired by Chung's lone ranger,
idiosyncratic and mistaken interpretation of the biblical measure of
volume, an omer.
Chung is a disgraced ex-cardiologist who lost his first post-
cardiology fellowship job in Ocala, Florida in about 3 months and has
not worked since. He is a pathological, regressed narcissist and a
known Usenet k00k and a pathological liar.
Respond to his posts for amusement value only. Nothing that he says is
evidence-based. |
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| Bob Arnold... |
Posted: Sun May 18, 2008 7:50 pm |
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In article <-5mdnfjWNLwkbbLVnZ2dnUVZ_tHinZ2d at (no spam) earthlink.com>,
Marshall Price <d021317c at (no spam) yahoo.com> wrote:
Quote: jay wrote:
What supplements provide relief from polyneuropathy?
Nobody seems to have mentioned the most obvious one, thiamine!
My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is
this too much?
It sounds like too much to me, but many people take that much, or
more. The multi-vitamin-mineral tablets I take afford about one DV
(that is, 100%) for each vitamin and mineral, except for the major
minerals. (For thiamine, that means 1.5mg.)
But I also take a few vitamins "on the side" for specific purposes,
and I expect to get most of my nutrients from food, not to mention the
zillions of honored guest symbiotes in my digestive tract. I'd be lost
without them.
It's not too much. I take 540mg Thiamine per day. |
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| Marshall Price... |
Posted: Tue May 20, 2008 9:28 am |
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Andrew B. Chung, MD/PhD wrote:
Quote: Marshall Price wrote:
Andrew, in the Holy Spirit, wrote in part:
By GOD's design, there is one optimal amount for every adult as
denoted by the Hebrew word "omer" (Exodus 16:16).
Why not save us the trouble of looking it up?
"Each one is to gather as much as he needs. Take an omer for each
person you have in your tent." -- LORD Almighty GOD (Exodus 16:16)
16 + 16 = 32
Reminding us that the one optimal amount is 32 ounces.
Huh?
You take the numbers from the chapter and verse? But those aren't in
the original. Then you add them together? Why? Why "ounces"?
"Optimal amount" of what? Manna? Per day?
An omer is a tenth of an ephah, which is about a bushel, which is
about 32 quarts, so an omer (as a measure of grain) is about 3.2 quarts.
That's "an optimal amount" for a day?
Why take something God said to the Israelites gathering manna in the
desert (if I recall correctly) as his "design" for "every adult"? And
where are you getting manna, anyway?
--
Marshall Price of Miami
Known to Yahoo as d021317c |
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| Marshall Price... |
Posted: Tue May 20, 2008 9:34 am |
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Truth wrote:
Quote: On May 18, 1:31 am, Marshall Price <d0213... at (no spam) yahoo.com> wrote:
Andrew B. Chung, MD/PhD wrote:
By GOD's design, there is one optimal amount for every adult as
denoted by the Hebrew word "omer" (Exodus 16:16).
Why not save us the trouble of looking it up?
--
Marshall Price of Miami
Known to Yahoo as d021317c
Chung has been told many times that scholars agree that an omer is a
biblical measure of volume equivalent to approximately 2 liters or
quarts. Yet he is fixated on the fact that the verse mentioning an
omer as being the right amount of food for the Israelites wandering in
the desert is Exodus 16:16. He therefore twists this to be numerology
"proof" that an omer is 2 pounds or 32 ounces.
Chung initially fixated on the 2 pounds per person per day diet when
he saw some IMAX film about Everest climbers and mistakenly came away
with the idea that those climbers ate only 2 pounds of food per day.
As his mental illness progressed and he became more fixated on quasi-
Christianity, this 2 pounds a day morphed from being inspired by the
IMAX Everest film into being inspired by Chung's lone ranger,
idiosyncratic and mistaken interpretation of the biblical measure of
volume, an omer.
Chung is a disgraced ex-cardiologist who lost his first post-
cardiology fellowship job in Ocala, Florida in about 3 months and has
not worked since. He is a pathological, regressed narcissist and a
known Usenet k00k and a pathological liar.
Respond to his posts for amusement value only. Nothing that he says is
evidence-based.
Well, what do you know! I wonder whether it's occurred to him that
two pounds of butter is different from two pounds of watermelon.
Roman soldiers used to march all day on a handful of dry wheat, but
they never read the Bible, so what did they know? ;-)
--
Marshall Price of Miami
Known to Yahoo as d021317c |
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| Andrew B. Chung, MD/PhD... |
Posted: Tue May 20, 2008 5:58 pm |
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neighbor Marshall Price wrote:
Quote: Andrew, in the Holy Spirit, boldly wrote:
neighbor Marshall Price wrote:
Andrew, in the Holy Spirit, wrote in part:
By GOD's design, there is one optimal amount for every adult as
denoted by the Hebrew word "omer" (Exodus 16:16).
Why not save us the trouble of looking it up?
"Each one is to gather as much as he needs. Take an omer for each
person you have in your tent." -- LORD Almighty GOD (Exodus 16:16)
16 + 16 = 32
Reminding us that the one optimal amount is 32 ounces.
Huh?
http://groups.google.com/group/sci.med.cardiology/msg/cf518e37250dcbe6?
Be hungry... be healthy... be hungrier... be healthier...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17? |
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| Andrew B. Chung, MD/PhD... |
Posted: Thu May 22, 2008 12:09 am |
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| Kofi... |
Posted: Thu May 22, 2008 1:23 am |
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Quote: And I ate two to six cups of cooked oat bran every day, which also
has been proven to work.
Make sure you rule out Celiac disease first. It's associated with
neuropathies. |
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| Kofi... |
Posted: Thu May 22, 2008 3:06 am |
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In article
<739091c9-61a5-4257-844a-cbc2e72bd0e6 at (no spam) r66g2000hsg.googlegroups.com>,
jay <jaym1212 at (no spam) hotmail.com> wrote:
Quote: What supplements provide relief from polyneuropathy? Would the
following be the most important? Already doing paleo-type diet,
moderate exercise and multi-vitamins.
Benfotiamine
Vitamin B6 (P-5-P)
R-Lipoic Acid
NAC
Acetyl-L-Carnitine
I've had neuropathy too.
A couple of points:
+ Stoke the GABA channel. Homocysteine blocks it, so anything that
lowers homocysteine should work - methyl-B12, folic acid, betaine, SAMe,
creatine, choline. (Insulin resistance interferes with GABA receptor
function, by the way.) You can boost GABA production per se with
magnesium, taurine and a few of the previously mentioned items.
Magnesium also antagonizes the actions of Substance P.
+ Check for molybdenum deficiency, which is common in diabetes and
depresses metallothionein synthesis. Also check for metals poisoning
and other toxicities.
+ Intermittent fasting - eat as much as you want the first day, then
fast the second day and repeat. Much easier than calorie restriction
and doesn't require expert nutritional supervision.
+ Acetyl-l-carnitine upregulates the low affinity nerve growth factor
receptor (p75NGFR) - thus its limited ability to regrow peripheral
nerves. p75 accelerates growth in some cancers (e.g. gliomas) and
shrinks other cancers. Make sure you understand what ALCAR is doing to
your cancer risk. (A high enough dose should also send your hair
follicles into catagen.)
+ Butyrate (~3g daily). It's an HDAC inhibitor produced in the gut
from fiber. It requires carnitine for absorption and metabolization.
Butyrate directly induces autophagy.
+ If you're taking lipoic acid, take plenty of biotin.
+ For pain relief, low-dose naltrexone blocks dependency, increases
analgesia and reduces tolerance/addiction when used in conjunction with
standard opioids.
+ Green tea extract (analgesia via PPARalpha agonism, maybe PKC
inhibition).
+ Atrial natriuretic factor (produced via certain types of heat stress).
+ gluatmine (HO-1)
+ Vitamin D3 (via HIF-1?).
+ DHEA (like carnitine, it's a PKC inhibitor and thus raises the pain
threshold).
+ Death of gut bacteria can lower the pain threshold [PMID 17159985].
+ Cox-2 inhibitors can actually induce autoimmunity and sometimes
sensitize nerves to pain. |
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| Kofi... |
Posted: Thu May 22, 2008 6:24 pm |
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Guest
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Forgot two strategic approaches specific to diabetes:
1) Raise the NAD+/NADH ratio. Niacinamide or niacin. This ratio
governs blood flow and directly affects neuropathy.
2) Inhibit GSK-3b. This should help alleviate insulin resistance.
Also, citrulline supplementation might be a better idea than arginine
for increasing nitric oxide. BH4 might also be helpful if you have high
homocysteine/OOHO- levels - although the increased catecholamine
synthesis by BH4 might actually enhance your sensitivity to pain even as
it improves your oxidative status. |
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| Marshall Price... |
Posted: Mon Jun 02, 2008 10:01 pm |
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Guest
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Bob Arnold wrote:
Quote: In article <-5mdnfjWNLwkbbLVnZ2dnUVZ_tHinZ2d at (no spam) earthlink.com>,
Marshall Price <d021317c at (no spam) yahoo.com> wrote:
jay wrote:
What supplements provide relief from polyneuropathy?
Nobody seems to have mentioned the most obvious one, thiamine!
My multi-vitamin says one tablet has 75mg of Thiamine HCl (5000%). Is
this too much?
It sounds like too much to me, but many people take that much, or
more. The multi-vitamin-mineral tablets I take afford about one DV
(that is, 100%) for each vitamin and mineral, except for the major
minerals. (For thiamine, that means 1.5mg.)
But I also take a few vitamins "on the side" for specific purposes,
and I expect to get most of my nutrients from food, not to mention the
zillions of honored guest symbiotes in my digestive tract. I'd be lost
without them. ;-)
It's not too much. I take 540mg Thiamine per day.
The general consensus suggests that taking that much thiamine may
lead to relative deficiencies of the other water-soluble vitamins. Do
you take any of them, and if not, are you looking out for deficiency
symptoms?
(Personally, I take lots of niacin [B3] and pyridoxine [B6], mainly
to keep my blood lipid profile healthy, along with riboflavin [B2] to
balance the pyridoxine, and a Centrum-like tablet for general
"insurance" purposes. But I do experiment, too.)
--
Marshall Price of Miami
Known to Yahoo as d021317c |
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| Marshall Price... |
Posted: Mon Jun 02, 2008 10:07 pm |
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Guest
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Kofi wrote:
Quote: In article
739091c9-61a5-4257-844a-cbc2e72bd0e6 at (no spam) r66g2000hsg.googlegroups.com>,
jay <jaym1212 at (no spam) hotmail.com> wrote:
What supplements provide relief from polyneuropathy? Would the
following be the most important? Already doing paleo-type diet,
moderate exercise and multi-vitamins.
Benfotiamine
Vitamin B6 (P-5-P)
R-Lipoic Acid
NAC
Acetyl-L-Carnitine
I've had neuropathy too.
A couple of points:
+ Stoke the GABA channel. Homocysteine blocks it, so anything that
lowers homocysteine should work - methyl-B12, folic acid, betaine, SAMe,
creatine, choline. (Insulin resistance interferes with GABA receptor
function, by the way.) You can boost GABA production per se with
magnesium, taurine and a few of the previously mentioned items.
Magnesium also antagonizes the actions of Substance P.
+ Check for molybdenum deficiency, which is common in diabetes and
depresses metallothionein synthesis. Also check for metals poisoning
and other toxicities.
+ Intermittent fasting - eat as much as you want the first day, then
fast the second day and repeat. Much easier than calorie restriction
and doesn't require expert nutritional supervision.
+ Acetyl-l-carnitine upregulates the low affinity nerve growth factor
receptor (p75NGFR) - thus its limited ability to regrow peripheral
nerves. p75 accelerates growth in some cancers (e.g. gliomas) and
shrinks other cancers. Make sure you understand what ALCAR is doing to
your cancer risk. (A high enough dose should also send your hair
follicles into catagen.)
+ Butyrate (~3g daily). It's an HDAC inhibitor produced in the gut
from fiber. It requires carnitine for absorption and metabolization.
Butyrate directly induces autophagy.
+ If you're taking lipoic acid, take plenty of biotin.
+ For pain relief, low-dose naltrexone blocks dependency, increases
analgesia and reduces tolerance/addiction when used in conjunction with
standard opioids.
+ Green tea extract (analgesia via PPARalpha agonism, maybe PKC
inhibition).
+ Atrial natriuretic factor (produced via certain types of heat stress).
+ gluatmine (HO-1)
+ Vitamin D3 (via HIF-1?).
+ DHEA (like carnitine, it's a PKC inhibitor and thus raises the pain
threshold).
+ Death of gut bacteria can lower the pain threshold [PMID 17159985].
+ Cox-2 inhibitors can actually induce autoimmunity and sometimes
sensitize nerves to pain.
Whew! That's a lot to absorb at one sitting.
About acetyl-L-carnitine, you said:
Quote: A high enough dose should also send your hair
follicles into catagen.
What does that mean? (I'm not familiar with the word "catagen.")
--
Marshall Price of Miami
Known to Yahoo as d021317c |
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| Marshall Price... |
Posted: Mon Jun 02, 2008 10:28 pm |
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Guest
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Kofi wrote:
Quote: Forgot two strategic approaches specific to diabetes:
1) Raise the NAD+/NADH ratio. Niacinamide or niacin. This ratio
governs blood flow and directly affects neuropathy.
2) Inhibit GSK-3b. This should help alleviate insulin resistance.
Also, citrulline supplementation might be a better idea than arginine
for increasing nitric oxide. BH4 might also be helpful if you have high
homocysteine/OOHO- levels - although the increased catecholamine
synthesis by BH4 might actually enhance your sensitivity to pain even as
it improves your oxidative status.
There's a bit of controversy over whether niacinamide and "non-flush"
or time-release forms of vitamin B-3 are as effective as plain niacin
(nicotinic acid) for lowering blood triglycerides, total cholesterol,
and LDL cholesterol, and raising HDL cholesterol. But there's no
question that niacin is quite effective, and the only complaint against
it is that it causes the famous niacin flush. But if you're familiar
with it and prepared for it, it's not only "no problem," but it can be
quite pleasant.
It makes me feel contented, healthy, and invigorated. It makes me
want to get moving, yawn, stretch, wash my face, take a shower, brush my
teeth, scrub my back, touch my toes, and so on.
Thiamine is a well-known tonic, but for me, at least, niacin acts as
a tonic, too.
About insulin resistance. In my reading about fasting, it seems that
almost everybody who advocates fasting (in any form) brings up insulin
resistance sooner or later, claiming that fasting cures it.
Since I personally fasted and lost a lot of weight at the same time,
without the benefit of a doctor's supervision, I don't know whether I
had insulin resistance, or if so, whether fasting or weight loss cured
it. But I can say it was the fear of metabolic syndrome which prompted
me, and with my waist down to thirty inches (max), I doubt I've got it,
but still suspect I'm prone to it.
All right. Enough anecdotal nonsense for now! :-)
--
Marshall Price of Miami
Known to Yahoo as d021317c |
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| jay... |
Posted: Tue Jun 03, 2008 11:00 am |
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Guest
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Quote: And I ate two to six cups of cooked oat bran every day,
which also has been proven to work.
Make sure you rule out Celiac disease first. It's associated with
neuropathies.
I think unadulterated oats are now considered safe; however, oats can
be contaminated by equipment/facilities that also process wheat,
barley or rye.
In the past, after eating Cinnamon Toast Crunch cereal (wheat, sugar,
rice flour, canola, fructose, maltodextrin, dextrose) for two weeks,
any meal with usual amount of hot chilies would cause both of my hands/
wrist to feel as if capsaicin was applied there direclty. Other corn/
oat based cereals didn't have this effect. |
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| jay... |
Posted: Tue Jun 03, 2008 12:02 pm |
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Quote: I've had neuropathy too.
Kofi, thanks for the exhaustive list.
Quote: ....check for metals poisoning and other toxicities.
I had my mercury amalgams removed now almost 20 years ago. Not sure if
that was a factor.
Quote: + Intermittent fasting
During short 12-hour fasts, I notice nerve pain/numbness subsides
considerably.
Quote: + Butyrate (~3g daily).
Would eating psyllium produce similar results?
Quote: + Green tea extract
Not sure, but tea seems to reduce my sciatica.
Quote: + Atrial natriuretic factor (produced via certain types of heat stress)..
Would hot showers work? |
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| jay... |
Posted: Wed Jun 04, 2008 8:18 am |
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Quote: In the past, after eating Cinnamon Toast Crunch cereal fo two weeks,
any meal with usual amount of hot chilies would cause both of my hands/
wrist to feel as if capsaicin was applied there direclty.
Did it also affect your feet?
No, and I haven't had any numbness/tingling in my feet. But they do
get sore from walking, possibly more so when consuming beef and
chicken.
Quote: Was it symmetrical?
Yes, the icy/hot feeling in hands and wrists was symmetrical.
Quote: Did you check your blood glucose?
No, but based on past measurements, it probably went in to the mid
100's.
Quote: I can't speak for anyone else but that many fast carbs would spike my
BG and cause the onset of peripheral neuropathy
Me too, and that was one of the reasons for shifting more to meats.
Quote: The chillies might just amplify the pain
Actually, the icy/hot feeling generated by chillies feels good in a
weird way and drowns out the more aggravating pain/numbness. |
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