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Circulation. 2008 May 13;117(19):2492-2501. Epub 2008 May 5. Links
Mitochondrial Haplogroups: Ischemic Cardiovascular Disease, Other
Diseases, Mortality, and Longevity in the General Population.Benn M,
Schwartz M, Nordestgaard BG, Tybjærg-Hansen A.
DMSc, Department of Clinical Biochemistry KB3011, Section for
Molecular Genetics, Rigshospitalet, Copenhagen University Hospital,
Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark. at-h at (no spam) rh.regionh.dk.
BACKGROUND: Rare mutations in the mitochondrial genome may cause
disease. Mitochondrial haplogroups defined by common polymorphisms
have been associated with risk of disease and longevity. We tested the
hypothesis that common haplogroups predict risk of ischemic
cardiovascular disease, morbidity from other causes, mortality, and
longevity in a general population of European descent. METHODS AND
RESULTS: We followed 9254 individuals from the Danish general
population, in the Copenhagen City Heart Study, prospectively for risk
of ischemic cardiovascular disease, morbidity from other causes, and
mortality during 25 and 11 years, respectively. Haplogroup frequencies
were as follows: H (45.9%), U (15.9%), T (9.9%), J (9.1), K (6.2%), V
(4.5%), W/I (3.8%), and Z (3.5%). Hazard ratios for hospitalization
due to all cardiovascular disorders (haplogroup U: 1.0 [95% confidence
interval{CI}, 0.9 to 1.1]; T: 0.9 [95% CI, 0.8 to 1.0]; J: 1.0 [95%
CI, 0.9 to 1.1]; K: 1.0 [95% CI, 0.9 to 1.2]; V: 1.0 [95% CI, 0.9 to
1.2]; W/I: 0.8 [95% CI, 0.7 to 1.0]; Z: 1.0 [95% CI, 0.8 to 1.2]),
ischemic heart disease (U: 0.9 [95% CI, 0.8 to 1.1]; T: 0.9 [95% CI,
0.7 to 1.0]; J: 1.1 [95% CI, 0.9 to 1.2]; K: 1.1 [95% CI, 0.9 to 1.3];
V: 1.1 [95% CI, 0.9 to 1.4]; W/I: 1.1 [95% CI, 0.8 to 1.4]; Z: 1.1
[95% CI, 0.8 to 1.4]), and ischemic cerebrovascular disease (U: 1.1
[95% CI, 0.9 to 1.4]; T: 0.9 [95% CI, 0.7 to 1.2]; J: 1.1 [95% CI, 0.9
to 1.4]; K: 1.0 [95% CI, 0.8 to 1.4]; V: 1.1 [95% CI, 0.8 to 1.5]; W/
I: 0.8 [95% CI, 0.5 to 1.3]; Z: 0.9 [95% CI, 0.6 to 1.4]) did not
differ from 1.0 for any haplogroup versus the most common haplogroup
H. Results were similar for hospitalization due to infectious and
parasitic diseases, respiratory infections, respiratory disorders,
malignant neoplasms, digestive disorders, musculoskeletal disorders,
neuropsychiatric disorders, and miscarriages. Likewise, hazard ratios
for death from all causes were not different from 1.0 for any
haplogroup versus haplogroup H (U: 1.0 [95% CI, 0.8 to 1.1]; T: 0.9
[95% CI, 0.8 to 1.1]; J: 0.9 [95% CI, 0.8 to 1.1]; K: 1.0 [95% CI, 0.8
to 1.2]; V: 1.1 [95% CI, 0.9 to 1.3]; W/I: 0.8 [95% CI, 0.7 to 1.1];
Z: 0.9 [95% CI, 0.7 to 1.2]). Finally, after stratification by major
causes of death, hazard ratios remained insignificant. CONCLUSIONS:
Our results do not support an association of mitochondrial haplogroups
with risk of ischemic cardiovascular disease, morbidity from other
causes, mortality, or longevity in a large general population of
European descent.
PMID: 18458168 [PubMed - as supplied by publisher] |
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