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Science Forum Index » Life Extension Forum » The impact of experimentally elevated energy...
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| rs1000b at (no spam) yahoo.com... |
 Posted: Sat May 10, 2008 8:05 am |
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Proc Biol Sci. 2008 May 8 [Epub ahead of print]
The impact of experimentally elevated energy expenditure on oxidative
stress and lifespan in the short-tailed field vole Microtus agrestis.
Selman C, McLaren JS, Collins AR, Duthie GG, Speakman JR.
Institute of Biological and Environmental Sciences, University of
Aberdeen, Aberdeen AB24 2TZ, UK.
Life-history theory assumes that animal life histories are a
consequence of trade-offs between current activities and future
reproductive performance or survival, because resource supply is
limited. Empirical evidence for such trade-offs in the wild are
common, yet investigations of the underlying mechanisms are rare. Life-
history trade-offs may have both physiological and ecological mediated
costs. One hypothesized physiological mechanism is that elevated
energy metabolism may increase reactive oxygen species production,
leading to somatic damage and thus compromising future survival. We
investigated the impact of experimentally elevated energy expenditure
on oxidative damage, protection and lifespan in short-tailed field
voles (Microtus agrestis) maintained in captivity to remove any
confounding ecological factor effects. Energy expenditure was elevated
via lifelong cold exposure (7+/-2 degrees C), relative to siblings in
the warm (22+/-2 degrees C). No treatment effect on cumulative
mortality risk was observed, with negligible effects on oxidative
stress and antioxidant protection. These data suggest that in captive
animals physiologically mediated costs on life history do not result
from increased energy expenditure and consequent elevations in
oxidative stress and reduced survival.
PMID: 18467297 [PubMed - as supplied by publisher] |
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