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Exp Cell Res. 2008 Mar 12 [Epub ahead of print] Links
Aging by epigenetics - a consequence of chromatin damage?Sedivy JM,
Banumathy G, Adams PD.
Brown University, Division of Biology and Medicine, Laboratories for
Molecular Medicine, 70 Ship Street, Providence, RI 02903, USA.
Chromatin structure is not fixed. Instead, chromatin is dynamic and is
subject to extensive developmental and age-associated remodeling. In
some cases, this remodeling appears to counter the aging and age-
associated diseases, such as cancer, and extend organismal lifespan.
However, stochastic non-deterministic changes in chromatin structure
might, over time, also contribute to the break down of nuclear, cell
and tissue function, and consequently aging and age-associated
diseases.
PMID: 18423606 [PubMed - as supplied by publisher] |
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