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Science Forum Index » Life Extension Forum » Vasoprotective Effects of Resveratrol and SIRT1:...
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 Posted: Fri May 09, 2008 2:18 pm |
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Guest
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This is probably good dude when using intellyjunce enancing drugs like
smokink dope. The SERT1s vasoprotectibe propirtoees is probably good
for the primaree runoff betwin Osama and Hilliree.
Am J Physiol Heart Circ Physiol. 2008 Apr 18 [Epub ahead of print]
Links
Vasoprotective Effects of Resveratrol and SIRT1: Attenuation of
Cigarette Smoke-induced Oxidative Stress and Pro-inflammatory
Phenotypic Alterations.Csiszar A, Labinskyy N, Podlutsky A, Kaminski
PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R,
Ballabh P, Ungvari ZI.
New York Medical College.
The dietary polyphenolic compound resveratrol, by activating the
protein deacetylase enzyme SIR2/SIRT1 prolongs lifespan in
evolutionarily distant organisms and may mimic the cytoprotective
effects of dietary restriction. The present study was designed to
elucidate the effects of resveratrol on cigarette smoke-induced
vascular oxidative stress and inflammation, which is a clinically
highly relevant model of accelerated vascular aging. Cigarette smoke
exposure of rats impaired acetylcholine-induced relaxation of carotid
arteries, which could be prevented by resveratrol treatment. Smoking
and in vitro treatment with cigarette smoke extract (CSE) increased
ROS production in rat arteries and cultured coronary arterial
endothelial cells (CAECs), respectively, which was attenuated by
resveratrol treatment. Smoking-induced up-regulation of inflammatory
markers (ICAM-1, iNOS, IL-6, TNFalpha) in rat arteries was also
abrogated by resveratrol treatment. Resveratrol also inhibited CSE-
induced NF-kappaB activation and inflammatory gene expression in
CAECs. In CAECs the aforementioned protective effects of resveratrol
were abolished by knockdown of SIRT1, whereas overexpression of SIRT1
mimicked the effects of resveratrol. Resveratrol treatment of rats
protected aortic endothelial cells against cigarette smoking-induced
apoptotic cell death. Resveratrol also exerted anti-apoptotic effects
in CSE-treated CAECs, which could be abrogated by knockdown of SIRT1.
Resveratrol treatment also attenuated CSE-induced DNA damage in CAECs
(comet assay). Thus, resveratrol and SIRT1 exert anti-oxidant, anti-
inflammatory and anti-apoptotic effects, which protect the endothelial
cells against the adverse effects of cigarette smoking-induced
oxidative stress. The vasoprotective effects of resveratrol will
likely contribute to its anti-aging action in mammals and may be
especially beneficial in pathophysiological conditions associated with
accelerated vascular aging. Key words: vascular aging, oxidative
stress, inflammation, tobacco.
PMID: 18424637 [PubMed - as supplied by publisher] |
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