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Science Forum Index » Life Extension Forum » Pituitary growth hormone suppression reduces resistin...
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 Posted: Fri May 09, 2008 2:12 pm |
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Exp Gerontol. 2008 Mar 20 [Epub ahead of print] Links
Pituitary growth hormone suppression reduces resistin expression and
enhances insulin effectiveness: Relationship with caloric
restriction.Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S,
Hayashi H, Higami Y, Shimokawa I.
Department of Investigative Pathology, Nagasaki University Graduate
School of Biomedical Sciences, Nagasaki, Nagasaki 852-8523, Japan.
Caloric restriction (CR) retards various age-dependent disorders,
increases lifespan, and improves insulin activity in laboratory
animals. Recently, adipocytes were found to act together as an active
endocrine organ that produces various hormones called adipocytokines.
The peripheral and central activities of these adipocytokines have
been suggested to mediate the anti-aging effects of CR. Here, we
tested this notion by analyzing the effect of CR and suppression of
growth hormone/insulin-like growth factor-I (GH/IGF-I) axis on the
expression of resistin, adiponectin, and adipsin genes by rat white
adipose tissue (WAT). We found that CR and GH/IGF-I suppression
markedly downregulated resistin gene expression. We also found plasma
resistin levels correlated positively with pituitary GH mRNA
expression levels. Our observations suggest that CR reduces resistin
expression and increases insulin effectiveness in a GH/IGF-I-dependent
manner. The beneficial effects of CR and GH/IGF-I suppression appear
to be mediated, at least in part, by changes in glucose metabolism
that result from reductions in plasma resistin levels.
PMID: 18430535 [PubMed - as supplied by publisher] |
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