| |
 |
|
|
Science Forum Index » Life Extension Forum » Colostrinintrade mark: An Oxidative Stress Modulator...
Page 1 of 1
|
| Author |
Message |
| ... |
 Posted: Fri May 09, 2008 2:10 pm |
|
|
|
Guest
|
J Alzheimers Dis. 2008 Jun;13(3):303-21. Links
Colostrinintrade mark: An Oxidative Stress Modulator for Prevention
and Treatment of Age-related Disorders.Boldogh I, Kruzel ML.
Department of Microbiology and Immunology, University of Texas Medical
Branch at Galveston, TX 77555, USA.
Colostrum-derived proline-rich polypeptide, also known as
Colostrinintrade mark (CLN), has been shown to have a stabilizing
effect on cognitive function in Alzheimer's disease patients. This
complex action of CLN could be related to prevention of amyloid-beta
peptide aggregation, as shown in in vitro studies, and its impact on
delicate cassettes of signaling pathways common to cellular redox
regulation, proliferation and differentiation. Studies on cultured
cells showed that CLN modulates intracellular levels of reactive
oxygen species (ROS), via regulation of glutathione metabolism,
activity of antioxidant enzymes and mitochondria function. Due to an
improvement in senescence-associated mitochondrial dysfunction and a
decrease in ROS generation, CLN decelerates the aging processes of
both cultured cells and experimental animals. When given orally to
mice, CLN increased the lifespan and improved various motor and
sensory activities. Although the molecular basis by which CLN exerts
its diverse effects are still under investigation, the regulatory
effect on the cellular redox state via maintenance of mitochondrial
function and modification of ROS-induced cell signaling seem to be of
great importance. In this article, we examine experimental data
pertinent to the mechanism of action, including a review of CLN's
utility in the maintenance of physiological processes in which
oxidative stress has an etiological role.
PMID: 18430998 [PubMed - in process] |
|
|
| Back to top |
|
| |
|
Page 1 of 1
All times are GMT - 5 Hours
The time now is Wed Jul 23, 2008 4:08 pm
|
|
