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Science Forum Index » Life Extension Forum » Nutritional control of reproductive status in...
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 Posted: Fri May 09, 2008 1:25 pm |
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Guest
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Queen bees live about 5 times as long as worker
bees.........Unfortunately we can't extrapolate that too
mammals...................sigh
Science. 2008 Mar 28;319(5871):1827-30. Epub 2008 Mar 13. Links
Nutritional control of reproductive status in honeybees via DNA
methylation.Kucharski R, Maleszka J, Foret S, Maleszka R.
Molecular Genetics and Evolution, ARC Centre for the Molecular
Genetics of Development, Research School of Biological Sciences,
Australian National University, Canberra ACT 0200, Australia.
Fertile queens and sterile workers are alternative forms of the adult
female honeybee that develop from genetically identical larvae
following differential feeding with royal jelly. We show that
silencing the expression of DNA methyltransferase Dnmt3, a key driver
of epigenetic global reprogramming, in newly hatched larvae led to a
royal jelly-like effect on the larval developmental trajectory; the
majority of Dnmt3 small interfering RNA-treated individuals emerged as
queens with fully developed ovaries. Our results suggest that DNA
methylation in Apis is used for storing epigenetic information, that
the use of that information can be differentially altered by
nutritional input, and that the flexibility of epigenetic
modifications underpins, profound shifts in developmental fates, with
massive implications for reproductive and behavioral status.
PMID: 18339900 [PubMed - indexed for MEDLINE] |
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