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Science Forum Index » Medicine - Cancer Forum » cardiac hormones extremely potent against cancer cells
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| Steve |
 Posted: Thu Feb 28, 2008 3:14 am |
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http://www.the-aps.org/press/journal/08/4.htm
The first two sentences of the above link says it all: "BETHESDA, Md. (Feb.
25, 2008) Hormones produced by the heart eliminated human pancreatic cancer
in more than three-quarters of the mice treated with the hormones and
eliminated human breast cancer in two-thirds of the mice, according to
researcher David Vesely, a doctor at the James A. Haley Veterans Hospital in
Tampa and a professor at the University of South Florida (USF)."
In the first Pubmed abstract below, the same researcher David Vesely in the
link above shows that Vessel dilator, the most potent cardiac hormone above,
inhibited ERK 1 and ERK 2 by 96% in prostate cancer cells while Kaliuretic
peptide which is another cardiac hormone mentioned in the above link but not
as potent against cancer cells as Vessel dilator, inhibited ERK 1/2 by 70%.
So it's possible that the extreme anti-cancer potency of Vessel dilator is
explained by its extreme inhibition of ERK 1/2.
http://www.ncbi.nlm.nih.gov/pubmed/17094432?ordinalpos=12&itool=EntrezSystem
2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
A nontoxic (to normal cells) agent that is a potent inhibitor of ERK 1/2 is
silymarin. Perhaps not coincidentally it is also a potent anti-cancer agent.
The link below shows that it not only inhibited skin cancer growth (of
existing tumors) in mice but caused a 43% regression in tumor size in those
tumors. The mice took the silymarin orally (according to the paper it was in
a DMSO solution because silymarin is fat soluble and not water soluble).
http://carcin.oxfordjournals.org/cgi/content/full/23/3/499#F3
According to that paper (see Figure 3), 0.5% silymarin in the mice inhibited
ERK 1 by 75% and ERK 2 by 50%. It's high inhibition of ERK 1/2 may explain
its high potency against cancer cells.
If one is going to use silymarin for cancer, use Silipide (trade name
Siliphos) which is a complex of silymarin and phosphatidylcholine (lecithin)
or something similar in a phosphatidylcholine base. This has much higher
bioavailability than regular silymarin when taken orally. Here's a Pubmed
abstract that showed that a silybin-phosphatidylcholine complex tested in
dogs was found to have a much higher bioavailability.
http://www.ncbi.nlm.nih.gov/pubmed/17348898?ordinalpos=1&itool=EntrezSystem2
..PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1 |
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