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Science Forum Index » Immunology Forum » Calcium ,Vitamin D strong bones and cancer
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| bigvince |
 Posted: Tue Oct 02, 2007 1:03 pm |
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Guest
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"Drink Your Milk: It May Prevent The Spread Of Breast Cancer To Bone"
Science Daily Oct. 2 ,2007
- A strong skeleton is less likely to be penetrated by metastasizing
cancer cells, so a fortified glass of milk might be the way to block
cancer's spread, according to researchers at the ANZAC Research
Institute in Concord, Australia.
Using a mouse model of breast cancer metastasis, the researchers found
that a calcium deficiency may increase the tendency of advanced breast
cancer to target bone. Dietary calcium, they reason, might help
prevent the spread of breast cancer to bone and serve as an adjuvant
treatment during therapy.
According to the researchers, about 70 percent of patients who develop
advanced breast cancer will have secondary tumors in the bone. The
spread of cancer to bones leads to cellular processes that physically
break down existing bone, leading to further pain and illness. In
fact, the breakdown of bone and subsequent bone re-growth forms what
senior author Colin R. Dunstan, Ph.D., terms a "vicious cycle" that
turns bone into an environment conducive to cancer growth.
To better understand the role of bone turnover in the spread of
cancer, Dunstan and his team compared the effects of a low- and high-
calcium diet in mice. They found that dietary calcium deficiency --
independent of the chemical factors that control turnover -- was
related to a significantly higher increase in cancer cell
proliferation and the total proportion of bone that had been
penetrated.
"These results could have implications for patients with breast cancer
bone metastases or who are at high risk for developing metastatic
disease," Dunstan said. "Many older women in our community are known
to be calcium deficient due to low calcium dietary intake or due to
vitamin D deficiency. These women could be at increased risk for the
devastating effects of bone metastases."
According to Dunstan, his results call for further, directed clinical
trials "to investigate how calcium and vitamin D status influence
progression to metastatic disease, and to determine if corrections of
calcium and vitamin D deficiencies are important in breast cancer
patients."
Their findings are presented in the Oct. 1 issue of Cancer Research, a
journal of the American Association for Cancer Research.
Thanks Vince |
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