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Science Forum Index » Medicine - Nursing Forum » Iron in Parkinson disease.
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| ironjustice |
 Posted: Wed May 23, 2007 9:27 am |
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<<snip>>
neuronal iron could lead to neurodegeneration in Parkinson disease.
<<snip>>
Neurology. 2007 May 22;68(21):1820-5.Individual dopaminergic neurons
show raised iron levels in Parkinson disease.Oakley AE, Collingwood
JF, Dobson J, Love G, Perrott HR, Edwardson JA, Elstner M, Morris CM.
Institute for Ageing and Health, Newcastle University, Newcastle upon
Tyne, UK.
OBJECTIVE: Evidence suggests that abnormal iron metabolism is
associated with Parkinson disease (PD), with raised iron levels found
in pathologically affected areas in PD. It is unknown if this elevated
iron is actually associated with neurons or reactive glia, and we
therefore addressed this issue by determining if raised iron was
present in single dopaminergic neurons. METHODS: We used unfixed
frozen sections from postmortem tissue of PD patients and elderly
normal individuals to avoid metal contamination and translocation.
Levels of iron and other elements were measured using sensitive and
specific wavelength dispersive electron probe x-ray microanalysis
coupled with cathodoluminescence spectroscopy in individual substantia
nigra dopaminergic neurons. RESULTS: We identified raised
intraneuronal iron in single defined substantia nigra neurons in PD
(mean neuronal iron 2,838 vs 1,611, p < 0.0001) but not in other
movement disorders such as Huntington disease. These findings were
unrelated to the density of remaining neurons. CONCLUSIONS: Primary
changes in neuronal iron could lead to neurodegeneration in Parkinson
disease.
PMID: 17515544 [PubMed - in process]
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
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| Guest |
| Posted: Wed May 23, 2007 9:43 am |
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"RESULTS: We identified raised intraneuronal iron in single defined
substantia nigra neurons in PD (mean neuronal iron 2,838 vs 1,611, p <
0.0001) but not in other movement disorders such as Huntington disease."
Oh well, there goes the iron causes all diseas notion. It does confirm
however the presence of lead in full of holes foot disorder. |
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| ironjustice@aol.com |
| Posted: Thu May 24, 2007 2:24 pm |
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Quote: On May 23, 7:43 am, keyst...@mark.com wrote: Oh well, there goes the iron causes all diseas notion.
What I like about you .. is your are a PERFECT example of someone in
the medical profession ..
"Oh there is no iron .. therefore I conclude iron is not involved in
those with Hungtingtons' .. somebody give me a pat on the back .. I
**deserve** a pat on the back BECAUSE .. I .. **am** soooo .. smart ..
but I'll settle for .. cash .. and lots of it .. " .. "yeah baby" ..
Isn't that about .. right .. ?
Heh .. heh ..
THAT is why they have now found out you jrkffs have been killing
millions of people ..
But someone IS .. going to show you .. the error .. OF .. your ways ..
S-c-i-e-n-c-e .. something you and your ilk .. are UNABLE to ..
combat ..
Because .. ?
You are collectively .. stupid ..
And in medicine .. that is a .. **bad** .. thing .. evidently .. DB's
and all .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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| Guest |
| Posted: Fri May 25, 2007 7:53 am |
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"RESULTS: We identified raised intraneuronal iron in single defined
substantia nigra neurons in PD (mean neuronal iron 2,838 vs 1,611, p <
0.0001) but not in other movement disorders such as Huntington disease."
Oh well, there goes the iron causes all diseas notion. It does confirm
however the presence of lead in full of holes foot disorder. |
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| ironjustice |
| Posted: Fri May 25, 2007 8:37 am |
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Quote: On May 25, 5:53 am, keyst...@mark.com wrote:
Oh well, there goes the iron causes all diseas notion.
The brain is large .. it contains .. many different structures ..
Here is a url .. for you to .. study ..
Post .. **when** .. you .. u-n-d-e-r-s-t-a-n-d ..
Understand .. ?
http://www.neuroanatomy.wisc.edu/virtualbrain/BrainStem/20Substantia.html
Neurochem Res. 2007 May 5; [Epub ahead of print]
Myelin Breakdown and Iron Changes in Huntington's Disease:
Pathogenesis and Treatment Implications.
Bartzokis G, Lu PH, Tishler TA, Fong SM, Oluwadara B, Finn JP, Huang
D, Bordelon Y, Mintz J, Perlman S.
Department of Neurology, The David Geffen School of Medicine at UCLA,
Los Angeles, CA, 90095, USA.
BACKGROUND: Postmortem and in vivo imaging data support the
hypothesis
that premature myelin breakdown and subsequent homeostatic
remyelination attempts with increased oligodendrocyte and iron levels
may contribute to Huntington's Disease (HD) pathogenesis and the
symmetrical progress of neuronal loss from earlier-myelinating
striatum to later-myelinating regions. A unique combination of in
vivo
tissue integrity and iron level assessments was used to examine the
hypothesis. METHODS: A method that uses two Magnetic resonance
imaging
(MRI) instruments operating at different field-strengths was used to
quantify the iron content of ferritin molecules (ferritin iron) as
well as tissue integrity in eight regions in 11 HD and a matched
group
of 27 healthy control subjects. Three white matter regions were
selected based on their myelination pattern (early to later-
myelinating) and fiber composition. These were frontal lobe white
matter (Fwm) and splenium and genu of the corpus callosum (Swm and
Gwm). In addition, gray matter structures were also chosen based on
their myelination pattern and fiber composition. Three striatum
structures were assessed [caudate, putamen, and globus pallidus (C,
P,
and G)] as well as two comparison gray matter regions that myelinate
later in development and are relatively spared in HD [Hippocampus
(Hipp) and Thalamus (Th)]. RESULTS: Compared to healthy controls, HD
ferritin iron levels were significantly increased in striatum C, P,
and G, decreased in Fwm and Gwm, and were unchanged in Hipp, Th, and
Swm. Loss of tissue integrity was observed in C, P, Fwm, and
especially Swm but not Hipp, Th, G, or Gwm. This pattern of findings
was largely preserved when a small subset of HD subjects early in the
disease process was examined. CONCLUSIONS: The data suggest early in
the HD process, myelin breakdown and changes in ferritin iron
distribution underlie the pattern of regional toxicity observed in
HD.
Prospective studies are needed to verify myelin breakdown and
increased iron levels are causal factors in HD pathogenesis. Tracking
the effects of novel interventions that reduce myelin breakdown and
iron accumulation in preclinical stages of HD could hasten the
development of preventive treatments.
PMID: 17484051 [PubMed - as supplied by publisher]
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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