"X. Summary
Diabetic neuropathy probably arises from a combination of
microvascular and neuronal deficits. Oxidative stress can contribute
significantly to these deficits and may be a direct result of
hyperglycemia. Brief postprandial peaks in plasma glucose are
sufficient to generate hyperglycemic oxidative stress. In contrast,
acute glucose deprivation also causes apoptosis of peripheral neurons
through a mechanism that at least partially involves oxidative stress
(205). Therefore, until we can fully control blood glucose levels,
therapies such as antioxidants that are targeted against oxidative
stress remain our most promising approach to preventing neuropathy as
well as other complications in diabeteshttp://edrv.endojournals.org/cgi/content/full/25/4/612"

Hello,

I view of above quote, diabetic neuropathy can be possible from excess
glucose and glucose deprivation(hyper/hypo glycemia). Is it right?

Can oxidative stress happen due to variations in blood flow and supply
to tissues by vasoconstrictions and vasodilations?

Best wishes.