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Science Forum Index » Anthropology - Paleo Forum » Testosterone and sepsis
Page 1 of 1
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| Author |
Message |
| James Michael Howard |
 Posted: Tue Feb 13, 2007 1:05 pm |
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Guest
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Acta Cir Bras. 2007 Feb;22(1):22-29
Effect of post-natal castration on sepsis mortality in rats
Bernhardt JA, D' Acampora AJ, Tramonte R, Serafim JD.
School of Medicine, University of Vale do Itajai, Santa Catarina, Brazil.
PURPOSE: To investigate the influence of castration in early periods of
development on survival to experimental acute sepsis. METHODS: Four groups
of 10 (ten) Wistar rats were used. The groups were comprised of males (M),
females (F), males castrated on the fourth day of life (CM) and males
castrated on the fourth day of life with testosterone replacement (CMR).
Sepsis was induced by ligature and cecal perforation in adult life.
RESULTS: The analysis of death within 24 hours following sepsis induction
showed greater mortality between the M and the CMR groups as compared to
the CM and F (p=0.0180) groups. Multiple correspondence analysis (MCA)
indicates an association between the M and the CMR groups for death within
24 hours as well as a relationship between the F and the CM groups for the
absence of death and death up to 24 hours following sepsis induction.
Statistical analysis of the Kaplan-Meier survival curve through log-rank
demonstrates a significant difference among the four groups (p=0.0055) and
between the M and the F (p=0.0005) groups. CONCLUSION: Data suggest a
better survival to sepsis within 24 hours for the F and CM groups, the
presence or absence of testosterone in early periods of post-natal life
being responsible for these findings. |
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| Chapstick |
| Posted: Tue Feb 13, 2007 9:30 pm |
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"James Michael Howard" <jmhoward@anthropogeny.com> wrote in message
news:8ur3t2pte3vfroa90leusihbnl9svd8aog@4ax.com...
Quote:
Acta Cir Bras. 2007 Feb;22(1):22-29
Effect of post-natal castration on sepsis mortality in rats
Bernhardt JA, D' Acampora AJ, Tramonte R, Serafim JD.
School of Medicine, University of Vale do Itajai, Santa Catarina, Brazil.
PURPOSE: To investigate the influence of castration in early periods of
development on survival to experimental acute sepsis. METHODS: Four groups
of 10 (ten) Wistar rats were used. The groups were comprised of males (M),
females (F), males castrated on the fourth day of life (CM) and males
castrated on the fourth day of life with testosterone replacement (CMR).
Sepsis was induced by ligature and cecal perforation in adult life.
RESULTS: The analysis of death within 24 hours following sepsis induction
showed greater mortality between the M and the CMR groups as compared to
the CM and F (p=0.0180) groups. Multiple correspondence analysis (MCA)
indicates an association between the M and the CMR groups for death within
24 hours as well as a relationship between the F and the CM groups for the
absence of death and death up to 24 hours following sepsis induction.
Statistical analysis of the Kaplan-Meier survival curve through log-rank
demonstrates a significant difference among the four groups (p=0.0055) and
between the M and the F (p=0.0005) groups. CONCLUSION: Data suggest a
better survival to sepsis within 24 hours for the F and CM groups, the
presence or absence of testosterone in early periods of post-natal life
being responsible for these findings.
Sorry... I can't much respond to this data... except perhaps to say it
sounds like a pretty gruesome experiement. hope it helps some gunshot
victims or appendix-burst kinda' problems....
Brief Question for you... a while back, you posted some data about
African-American men having more testosterone than other "races." (I use the
word race with some trepidation because of all the connotations and the
non-existence of "race" in the literature.) Has this data/experiement been
replicated? Seems to me that it is not a clear cut case... which "race" has
the most testosterone, or largest this or that.
TIA,
--chap |
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| James Michael Howard |
| Posted: Wed Feb 14, 2007 12:08 pm |
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On Tue, 13 Feb 2007 20:30:30 -0500, "Chapstick" <chapstick@nc.rr.com>
wrote:
Quote:
"James Michael Howard" <jmhoward@anthropogeny.com> wrote in message
news:8ur3t2pte3vfroa90leusihbnl9svd8aog@4ax.com...
Acta Cir Bras. 2007 Feb;22(1):22-29
Effect of post-natal castration on sepsis mortality in rats
Bernhardt JA, D' Acampora AJ, Tramonte R, Serafim JD.
School of Medicine, University of Vale do Itajai, Santa Catarina, Brazil.
PURPOSE: To investigate the influence of castration in early periods of
development on survival to experimental acute sepsis. METHODS: Four groups
of 10 (ten) Wistar rats were used. The groups were comprised of males (M),
females (F), males castrated on the fourth day of life (CM) and males
castrated on the fourth day of life with testosterone replacement (CMR).
Sepsis was induced by ligature and cecal perforation in adult life.
RESULTS: The analysis of death within 24 hours following sepsis induction
showed greater mortality between the M and the CMR groups as compared to
the CM and F (p=0.0180) groups. Multiple correspondence analysis (MCA)
indicates an association between the M and the CMR groups for death within
24 hours as well as a relationship between the F and the CM groups for the
absence of death and death up to 24 hours following sepsis induction.
Statistical analysis of the Kaplan-Meier survival curve through log-rank
demonstrates a significant difference among the four groups (p=0.0055) and
between the M and the F (p=0.0005) groups. CONCLUSION: Data suggest a
better survival to sepsis within 24 hours for the F and CM groups, the
presence or absence of testosterone in early periods of post-natal life
being responsible for these findings.
Sorry... I can't much respond to this data... except perhaps to say it
sounds like a pretty gruesome experiement. hope it helps some gunshot
victims or appendix-burst kinda' problems....
Brief Question for you... a while back, you posted some data about
African-American men having more testosterone than other "races." (I use the
word race with some trepidation because of all the connotations and the
non-existence of "race" in the literature.) Has this data/experiement been
replicated? Seems to me that it is not a clear cut case... which "race" has
the most testosterone, or largest this or that.
TIA,
--chap
Crit Care Med. 2006 Oct;34(10):2576-82.
The role of infection and comorbidity: Factors that influence disparities
in sepsis.
Esper AM, Moss M, Lewis CA, Nisbet R, Mannino DM, Martin GS.
Division of Pulmonary, Allergy and Critical Care Medicine, Department of
Medicine, Emory University, Atlanta, GA, USA.
OBJECTIVE: Large healthcare disparities exist in the incidence of sepsis
based on both race and gender. We sought to determine factors that may
influence the occurrence of these healthcare disparities, with respect to
the source of infection, causal organisms, and chronic comorbid medical
conditions. DESIGN: Historical cohort study. SETTING: U.S. acute care
hospitals from 1979 to 2003. PATIENTS: Hospitalized patients with a
diagnosis of sepsis were identified from the National Hospital Discharge
Survey per codes of the International Statistical Classification of
Diseases, Ninth Revision (ICD-9CM). Chronic comorbid medical conditions and
the source and type of infection were characterized by corresponding
ICD-9CM diagnoses. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS:
Sepsis incidence rates are mean cases per 100,000 after age adjustment to
the 2000 U.S. Census. Males and nonwhite races were confirmed at increased
risk for sepsis. Both proportional source distribution and incidence rates
favored respiratory sources of sepsis in males (36% vs. 29%, p < .01) and
genitourinary sources in females (35% vs. 27%, p < .01). Incidence rates
for all common sources of sepsis were greater in nonwhite races, but
proportional source distribution was approximately equal. After
stratification by the source of infection, males (proportionate ratio 1.16,
95% confidence interval 1.04-1.29) and black persons (proportionate ratio
1.25, 95% confidence interval 1.18-1.32) remained more likely to have
Gram-positive infections. Chronic comorbid conditions that alter immune
function (chronic renal failure, diabetes mellitus, HIV, alcohol abuse)
were more common in nonwhite sepsis patients, and cumulative comorbidities
were associated with greater acute organ dysfunction. Compared with white
sepsis patients, nonwhite sepsis patients had longer hospital length of
stay (2.0 days, 95% confidence interval 1.9-2.1) and were less likely to be
discharged to another medical facility (30% whites, 25% blacks, 18% other
races). Case-fatality rates were not significantly different across racial
and gender groups. CONCLUSIONS: Healthcare disparities exist in the
incidence of sepsis within all major sources of infection, and males and
blacks have greater frequency of Gram-positive infections independent of
the infection source. The differential distribution of specific chronic
comorbid medical conditions may contribute to these disparities. Large
cohort and administrative studies are required to confirm discrete root
causes of sepsis disparities. |
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