Does this mean that supplementing with S-AME, which puts methionine
into the body, can have bad effects?

Does this mean that supplementing with S-AME, which puts methionine
into the body, can have bad effects?

Maybe.

I really don't understand the rational behind taking methyl donors without
their methyl groups to donate. Merck makes an activated methylfolate that
sells as Metafolate, to supplement makers. It is not allowed in
Canada.(idiots)
snip

gehayw@hotmail.com> wrote in message
news:1127707067.530814.202300@g44g2000cwa.googlegroups.com...
Does this mean that supplementing with S-AME, which puts methionine
into the body, can have bad effects?

Maybe.

Just supplementing SAMe is not a good idea. SAMe is part of a chemical
cycle. SAMe is at the top of the cycle. After SAMe has made a methyl
donation, and another chemical donation, to fire up many chemical
processes in the body, it ends up as homocysteine. That is the bottom
of the cycle. Homocysteine is burnt out SAMe. Elevated homocysteine
levels indicate health problems, current and future.

Homocysteine can be eliminated quickly, by using B12, TMG, and zinc.
TMG can come from cholin, but you can take it as TMG. TMG, folic
acid, B12 are all methyl donors.
They will re-methylize the homocysteine, and with a bit of chemical
slight of hand, you have SAMe. You turn the bad stuff back into the
good stuff.

You have to turn the cycle over. It is no good pouring SAMe in at the
top of the cycle, because if the cycle does not turn over, it all just
accumulates at the bottom of the cycle as homocysteine. You need to
turn the cycle over and help your body make its own SAMe, out
homocysteine.

You can feed the cycle some methionine, to prevent depletion, due to
glutathione formation, by the B6 pathway, and cysteine loss to RNA
synthesis. Or you can take some NAC which is both a methyl and sulfur
donor.

B12, TMG, zinc, N-Acetyl-Cysteine.

TMG is also good for RNA and DNA, since they tend to use a lot of
methyl groups. And Tri-Methyl-Glycine can contribute three methyl
groups and strips to glycine, which is also used to make RNA.

Strongly, recommend B12 in the Methyl-Cobalamin sublingual form. Some
people have B12 absoption problems, due to a shortage of HCl or GIF.
Methyl-cobalamin sublingual bypasses absoption problems, and does not
need to be coverted. That is its active form.
Cyanocobalamin, releases cyanide to become active, and robs a methyl
group.

You can also take Folic acid, instead of TMG to convert homocysteine,
and should take folic acid too, since it is needed for RNA synthesis.
However, again the folic acid commonly used is not methylated and must
rob methyl groups from other processes to be activated. TMG can help
activate the folic acid, by donating some methyl groups. TMG can do
the job of re-methylating homocysteine, without being converted or
activated. TMG is the active form.

I really don't understand the rational behind taking methyl donors
without their methyl groups to donate. Merck makes an activated
methylfolate that sells as Metafolate, to supplement makers. It is not
allowed in Canada.(idiots)

However, folic acid, like SAMe, is a methyl donor. These both are
specifically involved in initiating chemical processes, by donating a
methyl group. Folic acid has the important job of helping to make RNA.
If you are short of folic acid, due to high demands for converting
homocysteine, RNA production can suffer.

RNA has been called "life force", It does all the work of making
proteins etc. RNA is like all the little workers in your body,
building things. DNA is a sort of reference library for RNA. If you
run short of RNA, you run short of workers to make things in you body.
You get run down. Your body cannot keep up with the insults and
stresses. Your health declines, mentally and physically.

Cruiser

This was very interesting. Should NAC be accompanied by something as
well? like glutamine or selenium perhaps?