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Science Forum Index » Life Extension Forum » Quercetin inhibits lactate, increases pyruvate in rat liver
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| kofi |
 Posted: Mon Jan 12, 2004 11:02 pm |
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Guest
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Time to add quercetin to resveratrol in the category of life-extending
supplements?
Xenobiotica. 2003 Sep;33(9):903-11. Related Articles, Links
Actions of quercetin on gluconeogenesis and glycolysis in rat liver.
Gasparin FR, Spitzner FL, Ishii-Iwamoto EL, Bracht A, Constantin J.
Laboratory of Liver Metabolism, Department of Biochemistry,
University of Maringa, 87020900 Maringa, Brazil.
1. The action of quercetin on glucose catabolism and production was
investigated in the perfused rat liver. 2. Quercetin inhibited lactate
production from glucose: 80% inhibition was found at a quercetin
concentration of 100 micro M, and at higher concentrations inhibition
was complete. 3. Pyruvate production from glucose presented a complex
pattern, but stimulation was evident at 100 and 300 micro M quercetin.
Oxygen uptake tended to be increased. 4. Glucose synthesis from lactate
and pyruvate was inhibited. Inhibition was already evident at 50 micro M
quercetin and almost complete at 300 micro M. Concomitantly, the
increment in oxygen uptake caused by lactate plus pyruvate was
stimulated by 50 micro M quercetin, but clearly inhibited by higher
concentrations (100-500 micro M). 5. Glucose phosphorylation in the
high-speed supernatant fractions of liver homogenates was inhibited by
quercetin, but only at concentrations above 150 micro M. 6. It is
concluded that quercetin can inhibit both glucose degradation and
production and increase the cytosolic NAD(+)/NADH ratio. 7. These
effects are likely to arise from many causes. Reduction of oxidative
phosphorylation, inhibition of Na(+)-K(+)-ATPase, inhibition of
glucokinase and inhibition of glucose 6-phosphatase could all contribute
to the overall action of quercetin.
PMID: 14514440 [PubMed - in process] |
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| RK |
| Posted: Tue Jan 13, 2004 12:24 pm |
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Guest
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kofi <kofi@anon.un> wrote in message news:<kofi-EA63B0.22024812012004@news01.west.earthlink.net>...
Quote: Time to add quercetin to resveratrol in the category of life-extending
supplements?
Maybe not. Quercetin inhibits the action of heat-shock proteins
(HSP-70), which in turn correlates with longevity and its expression
is up-regulated with CR.
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