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Science Forum Index » Life Extension Forum » hypoglycemic effect of urtica dioica
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| rs |
 Posted: Mon Jan 12, 2004 9:27 pm |
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Fitoterapia. 2003 Dec;74(7- :677-81.
Antihyperglycemic activity of the aqueous extract of Urtica dioica.
Bnouham M, Merhfour FZ, Ziyyat A, Mekhfi H, Aziz M, Legssyer A.
Laboratoire de Physiologie et Pharmacologie Cellulaire, UFR de
Physiologie et Pharmacologie, Departement de Biologie, Faculte des
Sciences, Universite Mohamed Ier, B.P. 524, Oujda, Morocco
When administered 30 min before glucose loading, the aqueous extract
of Urtica dioica (nettle) (250 mg/kg) showed a strong glucose lowering
effect. The decrease of glycemia has reached to 33+/-3.4% of the
control value 1 h after glucose loading. This effect was persistent
during 3 h. In contrast, nettle did not show hypoglycemic effect in
alloxan-induced diabetic rats. The amount of glucose absorbed in a
segment jejunum in situ was 8.05+/-0.68 mg in presence of nettle
extract vs. 11.11+/-0.75 mg in control rats during 2 h (P<0.05). The
results indicate that nettle has a significant antihyperglycemic
effect in OGTT model. This effect may be caused in part by the
reduction of intestinal glucose absorption. LD(50) is 3.5 g/kg (i.p.).
PMID: 14630172 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14630172&dopt=Abstract |
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