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1: Oncogene. 2003 Jun 26;22(26):4035-46. Related Articles, Links
VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits
tumor cell growth by blocking cell-cycle progression.
Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang
HM, Na YS, Yang Y, Lee KN, Choi I.
Laboratory of Immunology, Korea Research Institute of Bioscience and
Biotechnology, Yusong, Taejon 305-333, Republic of Korea.
Vitamin D(3) upregulated protein 1 (VDUP1) is a 1,25-dihydroxyvitamin
D(3) (1,25(OH)(2)D(3)) upregulated protein, and it is induced by
various stresses. In human tumor tissues, VDUP1 expression was
downregulated. Upon stimulation by growth-inhibitory signals such as
TGF-beta1 and 1,25(OH)(2)D(3), its expression was rapidly upregulated
as the cell growth was retarded. The transfection of VDUP1 in tumor
cells reduced cell growth. The VDUP1 expression was also increased
when the cell-cycle progression was arrested. Transfection of VDUP1
induced cell-cycle arrest at the G0/G1 phase, indicating that VDUP1
possesses a tumor-suppressive activity. In addition, it was found that
VDUP1 interacted with promyelocytic leukemia zinc-finger, Fanconi
anemia zinc-finger, and histone deacetylase 1, which are known to be
transcriptional corepressors. VDUP1 itself suppressed IL-3 receptor
and cyclin A2 promoter activity. Taken together, these results suggest
that VDUP1 is a novel antitumor gene which forms a transcriptional
repressor complex.
PMID: 12821938 [PubMed - indexed for MEDLINE]
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