| |
 |
|
|
Science Forum Index » Life Extension Forum » High ferritin, leptin levels linked to low testosterone in m
Page 1 of 1
|
| Author |
Message |
| kofi |
 Posted: Fri Jan 09, 2004 5:36 am |
|
|
|
Guest
|
J Endocrinol. 2002 Dec;175(3):745-56. Related Articles, Links
Click here to read
Definition and characterization of relative hypo- and
hyperleptinemia in a large Caucasian population.
Buettner R, Bollheimer LC, Zietz B, Drobnik W, Lackner K, Schmitz G,
Scholmerich J, Palitzsch KD.
Department of Internal Medicine I, University of Regensburg, 93042
Regensburg, Germany.
The adipocyte-derived hormone, leptin, has been implicated in the
regulation of appetite, weight gain and glucose homeostasis as well as
in liver fibrogenesis, hematopoiesis and immune function. No previous
reports have clearly defined pathologically elevated or decreased serum
leptin levels for Caucasian adults. The aim of this study was to define
and characterize subjects with relative hyper- and hypoleptinemia in a
large population-based German cohort. Percentiles of leptin levels by
body mass index (BMI) were calculated from 4971 adult Germans, and the
participants with leptin levels above the 95th and below the 5th
percentile were defined as relatively hyperleptinemic and relatively
hypoleptinemic, respectively, for their BMI. These participants were
compared with the intermediate group with respect to anthropometric and
clinical data and parameters of glucose and iron metabolism, lipid
status, renal, adrenal and reproductive function. Relatively
hyperleptinemic participants (HL) showed higher insulin, c-peptide, and
total cholesterol levels than the hypoleptinemic subjects; in males,
ferritin levels were higher and testosterone levels lower in the HL
group. In conclusion, we report the first percentile curves for serum
leptin by BMI in a large Caucasian population. Relatively low leptin
values may be associated with a lower metabolic risk than relatively
high serum leptin values.
PMID: 12475385 [PubMed - indexed for MEDLINE] |
|
|
| Back to top |
|
| |
|
Page 1 of 1
All times are GMT - 5 Hours
The time now is Mon Sep 08, 2008 11:20 am
|
|